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Clinicopathological Significance of EBV-Infected Gastric Carcinomas: A Meta-Analysis

Background and objectives: The present study aims to elucidate the clinicopathologic significance of Epstein–Barr virus (EBV) infection in gastric carcinomas (GCs) through a meta-analysis. Materials and Methods: Sixty-one eligible studies were included in the present meta-analysis. The included pati...

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Autores principales: Pyo, Jung-Soo, Kim, Nae-Yu, Kang, Dong-Wook
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7404405/
https://www.ncbi.nlm.nih.gov/pubmed/32668573
http://dx.doi.org/10.3390/medicina56070345
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author Pyo, Jung-Soo
Kim, Nae-Yu
Kang, Dong-Wook
author_facet Pyo, Jung-Soo
Kim, Nae-Yu
Kang, Dong-Wook
author_sort Pyo, Jung-Soo
collection PubMed
description Background and objectives: The present study aims to elucidate the clinicopathologic significance of Epstein–Barr virus (EBV) infection in gastric carcinomas (GCs) through a meta-analysis. Materials and Methods: Sixty-one eligible studies were included in the present meta-analysis. The included patients, with and without EBV infection, were 2063 and 17,684, respectively. We investigated the clinicopathologic characteristics and various biomarkers, including programmed death-ligand 1 (PD-L1) expression and tumor-infiltrating lymphocytes (TILs). Results: The estimated EBV-infected rate of GCs was 0.113 (95% confidence interval (CI): 0.088–0.143). The EBV infection rates in GC cells were 0.138 (95% CI: 0.096–0.194), 0.103 (95% CI: 0.077–0.137), 0.080 (95% CI: 0.061–0.106), and 0.042 (95% CI: 0.016–0.106) in the population of Asia, America, Europe, and Africa, respectively. There was a significant difference between EBV-infected and noninfected GCs in the male: female ratio, but not other clinicopathological characteristics. EBV infection rates were higher in GC with lymphoid stroma (0.573, 95% CI: 0.428–0.706) than other histologic types of GCs. There were significant differences in high AT-rich interactive domain-containing protein 1A (ARID1A) and PD-L1 expressions, and high CD8+ TILs between EBV-infected and noninfected GCs. Conclusions: Our results showed that EBV infection of GCs was frequently found in male patients and GCs with lymphoid stroma. EBV infection was significantly correlated with ARID1A and PD-L1 expressions and CD8+ TILs in GCs.
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spelling pubmed-74044052020-08-18 Clinicopathological Significance of EBV-Infected Gastric Carcinomas: A Meta-Analysis Pyo, Jung-Soo Kim, Nae-Yu Kang, Dong-Wook Medicina (Kaunas) Article Background and objectives: The present study aims to elucidate the clinicopathologic significance of Epstein–Barr virus (EBV) infection in gastric carcinomas (GCs) through a meta-analysis. Materials and Methods: Sixty-one eligible studies were included in the present meta-analysis. The included patients, with and without EBV infection, were 2063 and 17,684, respectively. We investigated the clinicopathologic characteristics and various biomarkers, including programmed death-ligand 1 (PD-L1) expression and tumor-infiltrating lymphocytes (TILs). Results: The estimated EBV-infected rate of GCs was 0.113 (95% confidence interval (CI): 0.088–0.143). The EBV infection rates in GC cells were 0.138 (95% CI: 0.096–0.194), 0.103 (95% CI: 0.077–0.137), 0.080 (95% CI: 0.061–0.106), and 0.042 (95% CI: 0.016–0.106) in the population of Asia, America, Europe, and Africa, respectively. There was a significant difference between EBV-infected and noninfected GCs in the male: female ratio, but not other clinicopathological characteristics. EBV infection rates were higher in GC with lymphoid stroma (0.573, 95% CI: 0.428–0.706) than other histologic types of GCs. There were significant differences in high AT-rich interactive domain-containing protein 1A (ARID1A) and PD-L1 expressions, and high CD8+ TILs between EBV-infected and noninfected GCs. Conclusions: Our results showed that EBV infection of GCs was frequently found in male patients and GCs with lymphoid stroma. EBV infection was significantly correlated with ARID1A and PD-L1 expressions and CD8+ TILs in GCs. MDPI 2020-07-13 /pmc/articles/PMC7404405/ /pubmed/32668573 http://dx.doi.org/10.3390/medicina56070345 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Pyo, Jung-Soo
Kim, Nae-Yu
Kang, Dong-Wook
Clinicopathological Significance of EBV-Infected Gastric Carcinomas: A Meta-Analysis
title Clinicopathological Significance of EBV-Infected Gastric Carcinomas: A Meta-Analysis
title_full Clinicopathological Significance of EBV-Infected Gastric Carcinomas: A Meta-Analysis
title_fullStr Clinicopathological Significance of EBV-Infected Gastric Carcinomas: A Meta-Analysis
title_full_unstemmed Clinicopathological Significance of EBV-Infected Gastric Carcinomas: A Meta-Analysis
title_short Clinicopathological Significance of EBV-Infected Gastric Carcinomas: A Meta-Analysis
title_sort clinicopathological significance of ebv-infected gastric carcinomas: a meta-analysis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7404405/
https://www.ncbi.nlm.nih.gov/pubmed/32668573
http://dx.doi.org/10.3390/medicina56070345
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