Upregulation of COL8A1 indicates poor prognosis across human cancer types and promotes the proliferation of gastric cancer cells

Gastric cancer (GC) was one of the most common types of the digestive system. COL8A1 was reported to be associated with cancer progression. The present study showed COL8A1 was overexpressed and correlated to shorter overall survival (OS) time across human cancer types. Specially, our results showed...

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Autores principales: Zhou, Jun, Song, Yaning, Gan, Wei, Liu, Liye, Chen, Guibing, Chen, Zhenyu, Luo, Guode, Zhang, Lin, Zhang, Guohu, Wang, Peihong, Cao, Yongkuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2020
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7405348/
https://www.ncbi.nlm.nih.gov/pubmed/32774507
http://dx.doi.org/10.3892/ol.2020.11895
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author Zhou, Jun
Song, Yaning
Gan, Wei
Liu, Liye
Chen, Guibing
Chen, Zhenyu
Luo, Guode
Zhang, Lin
Zhang, Guohu
Wang, Peihong
Cao, Yongkuan
author_facet Zhou, Jun
Song, Yaning
Gan, Wei
Liu, Liye
Chen, Guibing
Chen, Zhenyu
Luo, Guode
Zhang, Lin
Zhang, Guohu
Wang, Peihong
Cao, Yongkuan
author_sort Zhou, Jun
collection PubMed
description Gastric cancer (GC) was one of the most common types of the digestive system. COL8A1 was reported to be associated with cancer progression. The present study showed COL8A1 was overexpressed and correlated to shorter overall survival (OS) time across human cancer types. Specially, our results showed COL8A1 was up-regulated in advanced stage GC compared to low stage GC samples. Higher expression of COL8A1 was significantly correlated to shorter OS time in patients with GC. Bioinformatics analysis revealed COL8A1 was involved in regulating cell proliferation and metastasis. Experimental validations of COL8A1 showed that silencing of COL8A1 could significantly suppressed cell proliferation, migration and invasion in GC. These results provided a potential target for the clinical prognosis and treatment of gastric cancer.
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spelling pubmed-74053482020-08-06 Upregulation of COL8A1 indicates poor prognosis across human cancer types and promotes the proliferation of gastric cancer cells Zhou, Jun Song, Yaning Gan, Wei Liu, Liye Chen, Guibing Chen, Zhenyu Luo, Guode Zhang, Lin Zhang, Guohu Wang, Peihong Cao, Yongkuan Oncol Lett Articles Gastric cancer (GC) was one of the most common types of the digestive system. COL8A1 was reported to be associated with cancer progression. The present study showed COL8A1 was overexpressed and correlated to shorter overall survival (OS) time across human cancer types. Specially, our results showed COL8A1 was up-regulated in advanced stage GC compared to low stage GC samples. Higher expression of COL8A1 was significantly correlated to shorter OS time in patients with GC. Bioinformatics analysis revealed COL8A1 was involved in regulating cell proliferation and metastasis. Experimental validations of COL8A1 showed that silencing of COL8A1 could significantly suppressed cell proliferation, migration and invasion in GC. These results provided a potential target for the clinical prognosis and treatment of gastric cancer. D.A. Spandidos 2020-10 2020-07-21 /pmc/articles/PMC7405348/ /pubmed/32774507 http://dx.doi.org/10.3892/ol.2020.11895 Text en Copyright: © Zhou et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Articles
Zhou, Jun
Song, Yaning
Gan, Wei
Liu, Liye
Chen, Guibing
Chen, Zhenyu
Luo, Guode
Zhang, Lin
Zhang, Guohu
Wang, Peihong
Cao, Yongkuan
Upregulation of COL8A1 indicates poor prognosis across human cancer types and promotes the proliferation of gastric cancer cells
title Upregulation of COL8A1 indicates poor prognosis across human cancer types and promotes the proliferation of gastric cancer cells
title_full Upregulation of COL8A1 indicates poor prognosis across human cancer types and promotes the proliferation of gastric cancer cells
title_fullStr Upregulation of COL8A1 indicates poor prognosis across human cancer types and promotes the proliferation of gastric cancer cells
title_full_unstemmed Upregulation of COL8A1 indicates poor prognosis across human cancer types and promotes the proliferation of gastric cancer cells
title_short Upregulation of COL8A1 indicates poor prognosis across human cancer types and promotes the proliferation of gastric cancer cells
title_sort upregulation of col8a1 indicates poor prognosis across human cancer types and promotes the proliferation of gastric cancer cells
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7405348/
https://www.ncbi.nlm.nih.gov/pubmed/32774507
http://dx.doi.org/10.3892/ol.2020.11895
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