A virus-induced conformational switch of STAT1-STAT2 dimers boosts antiviral defenses

Type I interferons (IFN-I) protect us from viral infections. Signal transducer and activator of transcription 2 (STAT2) is a key component of interferon-stimulated gene factor 3 (ISGF3), which drives gene expression in response to IFN-I. Using electron microscopy, we found that, in naive cells, U-ST...

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Detalles Bibliográficos
Autores principales: Wang, Yuxin, Song, Qiaoling, Huang, Wei, Lin, Yuxi, Wang, Xin, Wang, Chenyao, Willard, Belinda, Zhao, Chenyang, Nan, Jing, Holvey-Bates, Elise, Wang, Zhuoya, Taylor, Derek, Yang, Jinbo, Stark, George R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Singapore 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7405385/
https://www.ncbi.nlm.nih.gov/pubmed/32759968
http://dx.doi.org/10.1038/s41422-020-0386-6

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