Statins Suppress TGF-β2-Mediated MMP-2 and MMP-9 Expression and Activation Through RhoA/ROCK Inhibition in Astrocytes of the Human Optic Nerve Head

PURPOSE: Matrix metalloproteinases (MMPs) are involved in extracellular matrix (ECM) maintenance and remodeling. The present study aimed to determine whether transforming growth factor (TGF)-β2 regulates MMP-2 and MMP-9 levels and activities in astrocytes derived from the optic nerve head (ONH) and...

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Detalles Bibliográficos
Autores principales: Kim, Mi-Lyang, Sung, Kyung Rim, Kwon, Junki, Shin, Jin A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Association for Research in Vision and Ophthalmology 2020
Materias:
Glaucoma
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7405691/
https://www.ncbi.nlm.nih.gov/pubmed/32421147
http://dx.doi.org/10.1167/iovs.61.5.29

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7405691/
https://www.ncbi.nlm.nih.gov/pubmed/32421147
http://dx.doi.org/10.1167/iovs.61.5.29

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