Cargando…

Statins Suppress TGF-β2-Mediated MMP-2 and MMP-9 Expression and Activation Through RhoA/ROCK Inhibition in Astrocytes of the Human Optic Nerve Head

PURPOSE: Matrix metalloproteinases (MMPs) are involved in extracellular matrix (ECM) maintenance and remodeling. The present study aimed to determine whether transforming growth factor (TGF)-β2 regulates MMP-2 and MMP-9 levels and activities in astrocytes derived from the optic nerve head (ONH) and...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kim, Mi-Lyang, Sung, Kyung Rim, Kwon, Junki, Shin, Jin A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Association for Research in Vision and Ophthalmology 2020
Materias:	Glaucoma
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7405691/ https://www.ncbi.nlm.nih.gov/pubmed/32421147 http://dx.doi.org/10.1167/iovs.61.5.29

Ejemplares similares

Astrocytes in the Optic Nerve Head of Glaucomatous Mice Display a Characteristic Reactive Phenotype
por: Wang, Rui, et al.
Publicado: (2017)

Optic Nerve Head Astrocytes Display Axon-Dependent and -Independent Reactivity in Response to Acutely Elevated Intraocular Pressure
por: Tehrani, Shandiz, et al.
Publicado: (2019)

Aberrant Collagen Composition of the Trabecular Meshwork Results in Reduced Aqueous Humor Drainage and Elevated IOP in MMP-9 Null Mice
por: De Groef, Lies, et al.
Publicado: (2016)

Pressure-Induced Changes in Astrocyte GFAP, Actin, and Nuclear Morphology in Mouse Optic Nerve
por: Ling, Yik Tung Tracy, et al.
Publicado: (2020)

Measuring Deformation in the Mouse Optic Nerve Head and Peripapillary Sclera
por: Nguyen, Cathy, et al.
Publicado: (2017)

Ultrastructural Morphology of the Optic Nerve Head in Aged and Glaucomatous Mice
por: Zhu, Ying, et al.
Publicado: (2018)

Seeing the Hidden Lamina: Effects of Exsanguination on the Optic Nerve Head
por: Tran, Huong, et al.
Publicado: (2018)

Optic Nerve Head Morphological Changes Over 12 Hours in Seated and Head-Down Tilt Postures
por: Pardon, Laura P., et al.
Publicado: (2020)

The Contribution of Sulfated Glycosaminoglycans to the Inflation Response of the Human Optic Nerve Head
por: Midgett, Dan E., et al.
Publicado: (2018)

How Myopia and Glaucoma Influence the Biomechanical Susceptibility of the Optic Nerve Head
por: Chuangsuwanich, Thanadet, et al.
Publicado: (2023)

Variation in Retinal Nerve Fiber Layer and Ganglion Cell Complex Associated With Optic Nerve Head Size in Healthy Eyes
por: Li, Caixia, et al.
Publicado: (2023)

Inhibition of TGF-β2–Induced Trabecular Meshwork Fibrosis by Pirfenidone
por: Zhu, Xiaofeng, et al.
Publicado: (2023)

Cerebrospinal Fluid Pressure: Revisiting Factors Influencing Optic Nerve Head Biomechanics
por: Hua, Yi, et al.
Publicado: (2018)

Regional Deformation of the Optic Nerve Head and Peripapillary Sclera During IOP Elevation
por: Pavlatos, Elias, et al.
Publicado: (2018)

Progressive Deformation of the Optic Nerve Head and Peripapillary Structures by Graded Horizontal Duction
por: Suh, Soh Youn, et al.
Publicado: (2017)

Quantitative Microstructural Analysis of Cellular and Tissue Remodeling in Human Glaucoma Optic Nerve Head
por: Guan, Carolyn, et al.
Publicado: (2022)

YAP/TAZ Mediate TGFβ2-Induced Schlemm's Canal Cell Dysfunction
por: Li, Haiyan, et al.
Publicado: (2022)

Mechanical Deformation of Human Optic Nerve Head and Peripapillary Tissue in Response to Acute IOP Elevation
por: Ma, Yanhui, et al.
Publicado: (2019)

Increased Optic Nerve Head Capillary Blood Flow in Early Primary Open-Angle Glaucoma
por: Gardiner, Stuart K., et al.
Publicado: (2019)

Effect of Changing Heart Rate on the Ocular Pulse and Dynamic Biomechanical Behavior of the Optic Nerve Head
por: Jin, Yuejiao, et al.
Publicado: (2020)

HDAC Inhibitor-Mediated Epigenetic Regulation of Glaucoma-Associated TGFβ2 in the Trabecular Meshwork
por: Bermudez, Jaclyn Y., et al.
Publicado: (2016)

Early Optic Nerve Head Glial Proliferation and Jak-Stat Pathway Activation in Chronic Experimental Glaucoma
por: Lozano, Diana C., et al.
Publicado: (2019)

The Effects of Negative Periocular Pressure on Biomechanics of the Optic Nerve Head and Cornea: A Computational Modeling Study
por: Safa, Babak N., et al.
Publicado: (2023)

Deep Optic Nerve Head Morphology in Tilted Disc Syndrome and Its Clinical Implication on Visual Damage
por: Lee, Eun Jung, et al.
Publicado: (2023)

RhoA, ROCK-1, and ROCK-2 Gene Expression and Polymorphisms in Cholesteatoma Patients
por: Görür, Kemal, et al.
Publicado: (2021)

TGFβ2-Hepcidin Feed-Forward Loop in the Trabecular Meshwork Implicates Iron in Glaucomatous Pathology
por: Ashok, Ajay, et al.
Publicado: (2020)

Comparison of Optic Nerve Head Microvasculature Between Normal-Tension Glaucoma and Nonarteritic Anterior Ischemic Optic Neuropathy
por: Kim, Ji-Ah, et al.
Publicado: (2021)

Three-Dimensional Light Field Fundus Imaging: Automatic Determination of Diagnostically Relevant Optic Nerve Head Parameters
por: Wegert, Laureen, et al.
Publicado: (2023)

Imaging video plethysmography shows reduced signal amplitude in glaucoma patients in the area of the microvascular tissue of the optic nerve head
por: Tornow, Ralf-Peter, et al.
Publicado: (2020)

Differences in Factors Associated With Glaucoma Progression With Lower Normal Intraocular Pressure in Superior and Inferior Halves of the Optic Nerve Head
por: Asaoka, Ryo, et al.
Publicado: (2023)

Role of ID Proteins in BMP4 Inhibition of Profibrotic Effects of TGF-β2 in Human TM Cells
por: Mody, Avani A., et al.
Publicado: (2017)

Using CRISPR Interference as a Therapeutic Approach to Treat TGFβ2-Induced Ocular Hypertension and Glaucoma
por: Rayana, Naga Pradeep, et al.
Publicado: (2021)

GDF‐5 induces epidermal stem cell migration via RhoA‐MMP9 signalling
por: Li, Xue, et al.
Publicado: (2020)

Experimental Glaucoma Causes Optic Nerve Head Neural Rim Tissue Compression: A Potentially Important Mechanism of Axon Injury
por: Fortune, Brad, et al.
Publicado: (2016)

Longitudinal In Vivo Changes in Radial Peripapillary Capillaries and Optic Nerve Head Structure in Non-Human Primates With Early Experimental Glaucoma
por: Musial, Gwen, et al.
Publicado: (2022)

AAV2-Mediated Transduction of the Mouse Retina After Optic Nerve Injury
por: Nickells, Robert W., et al.
Publicado: (2017)

Three-dimensional optic nerve head images using optical coherence tomography with a broad bandwidth, femtosecond, and mode-locked laser
por: Shoji, Takuhei, et al.
Publicado: (2014)

Variation in the Three-Dimensional Histomorphometry of the Normal Human Optic Nerve Head With Age and Race: Lamina Cribrosa and Peripapillary Scleral Thickness and Position
por: Girkin, Christopher A., et al.
Publicado: (2017)

Optic Nerve Head Myelin-Related Protein, GFAP, and Iba1 Alterations in Non-Human Primates With Early to Moderate Experimental Glaucoma
por: Chaudhary, Priya, et al.
Publicado: (2022)

TGF-β2 Promotes Oxidative Stress in Human Trabecular Meshwork Cells by Selectively Enhancing NADPH Oxidase 4 Expression
por: Rao, Vidhya R., et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_sbe11s2bt0stilusq3v8q6l6du