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Role of Arginase in Selective Impairment of Endothelium-Dependent Nitric Oxide Synthase-Mediated Dilation of Retinal Arterioles during Early Diabetes

PURPOSE: Retinal vasomotor activity can be regulated by two major endothelial enzymes, nitric oxide synthase (NOS) and cyclooxygenase (COX). The vascular arginase also consumes a NOS substrate and thus impedes NOS-mediated vasodilation. Diabetes mellitus exhibits vascular complications in the retina...

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Detalles Bibliográficos
Autores principales:	Hein, Travis W., Omae, Tsuneaki, Xu, Wenjuan, Yoshida, Akitoshi, Kuo, Lih
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Association for Research in Vision and Ophthalmology 2020
Materias:	Physiology and Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7405695/ https://www.ncbi.nlm.nih.gov/pubmed/32437549 http://dx.doi.org/10.1167/iovs.61.5.36

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