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Elevated Immunoglobulin G4 Levels in Patients with Thyroid Eye Disease and Their Clinical Implications
PURPOSE: The purpose of this study was to assess the relationship between thyroid eye disease (TED) in patients undergoing orbital decompression and immunoglobulin G4 (IgG4) levels. METHODS: A prospective observational cohort study was conducted among 185 consecutive patients who were diagnosed with...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Association for Research in Vision and Ophthalmology
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7405697/ https://www.ncbi.nlm.nih.gov/pubmed/32460318 http://dx.doi.org/10.1167/iovs.61.5.57 |
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author | Ye, Huijing Xiao, Wei Chen, Rongxin Zhang, Ping Tang, Lijuan Chen, Jingqiao Zhang, Te Ji, Xian Shi, Lu Yang, Huasheng |
author_facet | Ye, Huijing Xiao, Wei Chen, Rongxin Zhang, Ping Tang, Lijuan Chen, Jingqiao Zhang, Te Ji, Xian Shi, Lu Yang, Huasheng |
author_sort | Ye, Huijing |
collection | PubMed |
description | PURPOSE: The purpose of this study was to assess the relationship between thyroid eye disease (TED) in patients undergoing orbital decompression and immunoglobulin G4 (IgG4) levels. METHODS: A prospective observational cohort study was conducted among 185 consecutive patients who were diagnosed with TED and underwent orbital decompression. Serum levels of IgG4 were measured, and immunohistochemical staining for IgG and IgG4 was performed in orbital adipose tissue. Data related to clinicopathologic features were analyzed. RESULTS: Among the 185 enrolled patients with TED, 64 (34.6%) were IgG4-positive. The IgG4-positive patients were older, had higher clinical activity scores (CAS), and had worse best-corrected visual acuity (BCVA) than the IgG4-negative patients. Higher thyrotropin receptor antibody (TRAb) levels, histopathological IgG4 counts, IgG4/IgG ratios, and dense lymphocyte infiltration were more frequently observed in IgG4-positive than in IgG4-negative patients. Definitive and probable IgG4 subtypes were independently associated with the active stage in patients with TED. CONCLUSIONS: Our data suggest that the IgG4 subtype in TED is common. IgG4-positive patients with TED may be older, have more severe disease, and have higher clinical activity scores. IgG4 may play an important role in the pathogenesis of TED. |
format | Online Article Text |
id | pubmed-7405697 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | The Association for Research in Vision and Ophthalmology |
record_format | MEDLINE/PubMed |
spelling | pubmed-74056972020-08-19 Elevated Immunoglobulin G4 Levels in Patients with Thyroid Eye Disease and Their Clinical Implications Ye, Huijing Xiao, Wei Chen, Rongxin Zhang, Ping Tang, Lijuan Chen, Jingqiao Zhang, Te Ji, Xian Shi, Lu Yang, Huasheng Invest Ophthalmol Vis Sci Clinical and Epidemiologic Research PURPOSE: The purpose of this study was to assess the relationship between thyroid eye disease (TED) in patients undergoing orbital decompression and immunoglobulin G4 (IgG4) levels. METHODS: A prospective observational cohort study was conducted among 185 consecutive patients who were diagnosed with TED and underwent orbital decompression. Serum levels of IgG4 were measured, and immunohistochemical staining for IgG and IgG4 was performed in orbital adipose tissue. Data related to clinicopathologic features were analyzed. RESULTS: Among the 185 enrolled patients with TED, 64 (34.6%) were IgG4-positive. The IgG4-positive patients were older, had higher clinical activity scores (CAS), and had worse best-corrected visual acuity (BCVA) than the IgG4-negative patients. Higher thyrotropin receptor antibody (TRAb) levels, histopathological IgG4 counts, IgG4/IgG ratios, and dense lymphocyte infiltration were more frequently observed in IgG4-positive than in IgG4-negative patients. Definitive and probable IgG4 subtypes were independently associated with the active stage in patients with TED. CONCLUSIONS: Our data suggest that the IgG4 subtype in TED is common. IgG4-positive patients with TED may be older, have more severe disease, and have higher clinical activity scores. IgG4 may play an important role in the pathogenesis of TED. The Association for Research in Vision and Ophthalmology 2020-05-27 /pmc/articles/PMC7405697/ /pubmed/32460318 http://dx.doi.org/10.1167/iovs.61.5.57 Text en Copyright 2020 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. |
spellingShingle | Clinical and Epidemiologic Research Ye, Huijing Xiao, Wei Chen, Rongxin Zhang, Ping Tang, Lijuan Chen, Jingqiao Zhang, Te Ji, Xian Shi, Lu Yang, Huasheng Elevated Immunoglobulin G4 Levels in Patients with Thyroid Eye Disease and Their Clinical Implications |
title | Elevated Immunoglobulin G4 Levels in Patients with Thyroid Eye Disease and Their Clinical Implications |
title_full | Elevated Immunoglobulin G4 Levels in Patients with Thyroid Eye Disease and Their Clinical Implications |
title_fullStr | Elevated Immunoglobulin G4 Levels in Patients with Thyroid Eye Disease and Their Clinical Implications |
title_full_unstemmed | Elevated Immunoglobulin G4 Levels in Patients with Thyroid Eye Disease and Their Clinical Implications |
title_short | Elevated Immunoglobulin G4 Levels in Patients with Thyroid Eye Disease and Their Clinical Implications |
title_sort | elevated immunoglobulin g4 levels in patients with thyroid eye disease and their clinical implications |
topic | Clinical and Epidemiologic Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7405697/ https://www.ncbi.nlm.nih.gov/pubmed/32460318 http://dx.doi.org/10.1167/iovs.61.5.57 |
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