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author Au, Adrian
Hilely, Assaf
Scharf, Jackson
Gunnemann, Frederic
Wang, Derrick
Chehaibou, Ismael
Iovino, Claudio
Grondin, Christelle
Farecki, Marie-Louise
Falavarjani, Khalil Ghasemi
Phasukkijwatana, Nopasak
Battista, Marco
Borrelli, Enrico
Sacconi, Riccardo
Powell, Brittany
Hom, Grant
Greenlee, Tyler E.
Conti, Thais F.
Ledesma-Gil, Gerardo
Teke, Mehmet Yasin
Choudhry, Netan
Fung, Adrian T.
Krivosic, Valerie
Baek, Jiwon
Lee, Mee Yon
Sugiura, Yoshimi
Querques, Giuseppe
Peiretti, Enrico
Rosen, Richard
Lee, Won Ki
Yannuzzi, Lawrence A.
Zur, Dinah
Loewenstein, Anat
Pauleikhoff, Daniel
Singh, Rishi
Modi, Yasha
Hubschman, Jean Pierre
Ip, Michael
Sadda, SriniVas
Freund, K. Bailey
Sarraf, David
author_facet Au, Adrian
Hilely, Assaf
Scharf, Jackson
Gunnemann, Frederic
Wang, Derrick
Chehaibou, Ismael
Iovino, Claudio
Grondin, Christelle
Farecki, Marie-Louise
Falavarjani, Khalil Ghasemi
Phasukkijwatana, Nopasak
Battista, Marco
Borrelli, Enrico
Sacconi, Riccardo
Powell, Brittany
Hom, Grant
Greenlee, Tyler E.
Conti, Thais F.
Ledesma-Gil, Gerardo
Teke, Mehmet Yasin
Choudhry, Netan
Fung, Adrian T.
Krivosic, Valerie
Baek, Jiwon
Lee, Mee Yon
Sugiura, Yoshimi
Querques, Giuseppe
Peiretti, Enrico
Rosen, Richard
Lee, Won Ki
Yannuzzi, Lawrence A.
Zur, Dinah
Loewenstein, Anat
Pauleikhoff, Daniel
Singh, Rishi
Modi, Yasha
Hubschman, Jean Pierre
Ip, Michael
Sadda, SriniVas
Freund, K. Bailey
Sarraf, David
author_sort Au, Adrian
collection PubMed
description PURPOSE: To evaluate the depth and pattern of retinal hemorrhage in acute central retinal vein occlusion (CRVO) and to correlate these with visual and anatomic outcomes. METHODS: Retinal hemorrhages were evaluated with color fundus photography and fluorescein angiography at baseline and follow-up. Snellen visual acuity (VA), central foveal thickness (CFT), extent of retinal ischemia, and development of neovascularization were analyzed. RESULTS: 108 eyes from 108 patients were evaluated. Mean age was 63.6 ± 16.1 years with a predilection for the right eye (73.1%). Average follow-up was 17.2 ± 19.2 months. Mean VA at baseline was 20/126 and 20/80 at final follow-up. Baseline (P = 0.005) and final VA (P = 0.02) in eyes with perivascular nerve fiber layer (NFL) hemorrhages were significantly worse than in eyes with deep hemorrhages alone. Baseline CFT was greater in the group with perivascular hemorrhages (826 ± 394 µm) compared to the group with deep hemorrhages alone (455 ± 273 µm, P < 0.001). The 10 disc areas of retinal ischemia was more common in patients with perivascular (80.0%) and peripapillary (31.3%) versus deep hemorrhages alone (16.1%, P < 0.001). Neovascularization of the iris was more common, although this differrence was not significant, in the groups with peripapillary (14.3%) and perivascular (2.0%) NFL versus deep hemorrhages alone (0.0%). CONCLUSIONS: NFL retinal hemorrhages at baseline correlate with more severe forms of CRVO, with greater macular edema, poorer visual outcomes, and greater risk of ischemia and neovascularization. This may be related to the organization of the retinal capillary plexus. The depth and pattern of distribution of retinal hemorrhages in CRVO may provide an easily identifiable early biomarker of CRVO prognosis.
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spelling pubmed-74057002020-08-19 Relationship Between Nerve Fiber Layer Hemorrhages and Outcomes in Central Retinal Vein Occlusion Au, Adrian Hilely, Assaf Scharf, Jackson Gunnemann, Frederic Wang, Derrick Chehaibou, Ismael Iovino, Claudio Grondin, Christelle Farecki, Marie-Louise Falavarjani, Khalil Ghasemi Phasukkijwatana, Nopasak Battista, Marco Borrelli, Enrico Sacconi, Riccardo Powell, Brittany Hom, Grant Greenlee, Tyler E. Conti, Thais F. Ledesma-Gil, Gerardo Teke, Mehmet Yasin Choudhry, Netan Fung, Adrian T. Krivosic, Valerie Baek, Jiwon Lee, Mee Yon Sugiura, Yoshimi Querques, Giuseppe Peiretti, Enrico Rosen, Richard Lee, Won Ki Yannuzzi, Lawrence A. Zur, Dinah Loewenstein, Anat Pauleikhoff, Daniel Singh, Rishi Modi, Yasha Hubschman, Jean Pierre Ip, Michael Sadda, SriniVas Freund, K. Bailey Sarraf, David Invest Ophthalmol Vis Sci Retina PURPOSE: To evaluate the depth and pattern of retinal hemorrhage in acute central retinal vein occlusion (CRVO) and to correlate these with visual and anatomic outcomes. METHODS: Retinal hemorrhages were evaluated with color fundus photography and fluorescein angiography at baseline and follow-up. Snellen visual acuity (VA), central foveal thickness (CFT), extent of retinal ischemia, and development of neovascularization were analyzed. RESULTS: 108 eyes from 108 patients were evaluated. Mean age was 63.6 ± 16.1 years with a predilection for the right eye (73.1%). Average follow-up was 17.2 ± 19.2 months. Mean VA at baseline was 20/126 and 20/80 at final follow-up. Baseline (P = 0.005) and final VA (P = 0.02) in eyes with perivascular nerve fiber layer (NFL) hemorrhages were significantly worse than in eyes with deep hemorrhages alone. Baseline CFT was greater in the group with perivascular hemorrhages (826 ± 394 µm) compared to the group with deep hemorrhages alone (455 ± 273 µm, P < 0.001). The 10 disc areas of retinal ischemia was more common in patients with perivascular (80.0%) and peripapillary (31.3%) versus deep hemorrhages alone (16.1%, P < 0.001). Neovascularization of the iris was more common, although this differrence was not significant, in the groups with peripapillary (14.3%) and perivascular (2.0%) NFL versus deep hemorrhages alone (0.0%). CONCLUSIONS: NFL retinal hemorrhages at baseline correlate with more severe forms of CRVO, with greater macular edema, poorer visual outcomes, and greater risk of ischemia and neovascularization. This may be related to the organization of the retinal capillary plexus. The depth and pattern of distribution of retinal hemorrhages in CRVO may provide an easily identifiable early biomarker of CRVO prognosis. The Association for Research in Vision and Ophthalmology 2020-05-27 /pmc/articles/PMC7405700/ /pubmed/32460316 http://dx.doi.org/10.1167/iovs.61.5.54 Text en Copyright 2020 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
spellingShingle Retina
Au, Adrian
Hilely, Assaf
Scharf, Jackson
Gunnemann, Frederic
Wang, Derrick
Chehaibou, Ismael
Iovino, Claudio
Grondin, Christelle
Farecki, Marie-Louise
Falavarjani, Khalil Ghasemi
Phasukkijwatana, Nopasak
Battista, Marco
Borrelli, Enrico
Sacconi, Riccardo
Powell, Brittany
Hom, Grant
Greenlee, Tyler E.
Conti, Thais F.
Ledesma-Gil, Gerardo
Teke, Mehmet Yasin
Choudhry, Netan
Fung, Adrian T.
Krivosic, Valerie
Baek, Jiwon
Lee, Mee Yon
Sugiura, Yoshimi
Querques, Giuseppe
Peiretti, Enrico
Rosen, Richard
Lee, Won Ki
Yannuzzi, Lawrence A.
Zur, Dinah
Loewenstein, Anat
Pauleikhoff, Daniel
Singh, Rishi
Modi, Yasha
Hubschman, Jean Pierre
Ip, Michael
Sadda, SriniVas
Freund, K. Bailey
Sarraf, David
Relationship Between Nerve Fiber Layer Hemorrhages and Outcomes in Central Retinal Vein Occlusion
title Relationship Between Nerve Fiber Layer Hemorrhages and Outcomes in Central Retinal Vein Occlusion
title_full Relationship Between Nerve Fiber Layer Hemorrhages and Outcomes in Central Retinal Vein Occlusion
title_fullStr Relationship Between Nerve Fiber Layer Hemorrhages and Outcomes in Central Retinal Vein Occlusion
title_full_unstemmed Relationship Between Nerve Fiber Layer Hemorrhages and Outcomes in Central Retinal Vein Occlusion
title_short Relationship Between Nerve Fiber Layer Hemorrhages and Outcomes in Central Retinal Vein Occlusion
title_sort relationship between nerve fiber layer hemorrhages and outcomes in central retinal vein occlusion
topic Retina
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7405700/
https://www.ncbi.nlm.nih.gov/pubmed/32460316
http://dx.doi.org/10.1167/iovs.61.5.54
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