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KCNJ13 Gene Deletion Impairs Cell Alignment and Phagocytosis in Retinal Pigment Epithelium Derived from Human-Induced Pluripotent Stem Cells

PURPOSE: The purpose of this study was to establish and analyze a cell model of Leber congenital amaurosis type 16 (LCA16), which is caused by mutations in the KCNJ13 gene encoding Kir7.1, an inward-rectifying potassium ion channel. METHODS: The two guide RNAs specific to the target sites in the KCN...

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Detalles Bibliográficos
Autores principales:	Kanzaki, Yuki, Fujita, Hirofumi, Sato, Keita, Hosokawa, Mio, Matsumae, Hiroshi, Shiraga, Fumio, Morizane, Yuki, Ohuchi, Hideyo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Association for Research in Vision and Ophthalmology 2020
Materias:	Biochemistry and Molecular Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7405706/ https://www.ncbi.nlm.nih.gov/pubmed/32437550 http://dx.doi.org/10.1167/iovs.61.5.38

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