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The COVID-19 Vaccine Race: Challenges and Opportunities in Vaccine Formulation
In the race for a safe and effective vaccine against coronavirus disease (COVID)-19, pharmaceutical formulation science plays a critical role throughout the development, manufacturing, distribution, and vaccination phases. The proper choice of the type of vaccine, carrier or vector, adjuvant, excipi...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer International Publishing
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7405756/ https://www.ncbi.nlm.nih.gov/pubmed/32761294 http://dx.doi.org/10.1208/s12249-020-01744-7 |
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author | Wang, Jieliang Peng, Ying Xu, Haiyue Cui, Zhengrong Williams , Robert O. |
author_facet | Wang, Jieliang Peng, Ying Xu, Haiyue Cui, Zhengrong Williams , Robert O. |
author_sort | Wang, Jieliang |
collection | PubMed |
description | In the race for a safe and effective vaccine against coronavirus disease (COVID)-19, pharmaceutical formulation science plays a critical role throughout the development, manufacturing, distribution, and vaccination phases. The proper choice of the type of vaccine, carrier or vector, adjuvant, excipients, dosage form, and route of administration can directly impact not only the immune responses induced and the resultant efficacy against COVID-19, but also the logistics of manufacturing, storing and distributing the vaccine, and mass vaccination. In this review, we described the COVID-19 vaccines that are currently tested in clinical trials and provided in-depth insight into the various types of vaccines, their compositions, advantages, and potential limitations. We also addressed how challenges in vaccine distribution and administration may be alleviated by applying vaccine-stabilization strategies and the use of specific mucosal immune response-inducing, non-invasive routes of administration, which must be considered early in the development process. |
format | Online Article Text |
id | pubmed-7405756 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Springer International Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-74057562020-08-05 The COVID-19 Vaccine Race: Challenges and Opportunities in Vaccine Formulation Wang, Jieliang Peng, Ying Xu, Haiyue Cui, Zhengrong Williams , Robert O. AAPS PharmSciTech Review Article In the race for a safe and effective vaccine against coronavirus disease (COVID)-19, pharmaceutical formulation science plays a critical role throughout the development, manufacturing, distribution, and vaccination phases. The proper choice of the type of vaccine, carrier or vector, adjuvant, excipients, dosage form, and route of administration can directly impact not only the immune responses induced and the resultant efficacy against COVID-19, but also the logistics of manufacturing, storing and distributing the vaccine, and mass vaccination. In this review, we described the COVID-19 vaccines that are currently tested in clinical trials and provided in-depth insight into the various types of vaccines, their compositions, advantages, and potential limitations. We also addressed how challenges in vaccine distribution and administration may be alleviated by applying vaccine-stabilization strategies and the use of specific mucosal immune response-inducing, non-invasive routes of administration, which must be considered early in the development process. Springer International Publishing 2020-08-05 /pmc/articles/PMC7405756/ /pubmed/32761294 http://dx.doi.org/10.1208/s12249-020-01744-7 Text en © American Association of Pharmaceutical Scientists 2020 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic. |
spellingShingle | Review Article Wang, Jieliang Peng, Ying Xu, Haiyue Cui, Zhengrong Williams , Robert O. The COVID-19 Vaccine Race: Challenges and Opportunities in Vaccine Formulation |
title | The COVID-19 Vaccine Race: Challenges and Opportunities in Vaccine Formulation |
title_full | The COVID-19 Vaccine Race: Challenges and Opportunities in Vaccine Formulation |
title_fullStr | The COVID-19 Vaccine Race: Challenges and Opportunities in Vaccine Formulation |
title_full_unstemmed | The COVID-19 Vaccine Race: Challenges and Opportunities in Vaccine Formulation |
title_short | The COVID-19 Vaccine Race: Challenges and Opportunities in Vaccine Formulation |
title_sort | covid-19 vaccine race: challenges and opportunities in vaccine formulation |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7405756/ https://www.ncbi.nlm.nih.gov/pubmed/32761294 http://dx.doi.org/10.1208/s12249-020-01744-7 |
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