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The COVID-19 Vaccine Race: Challenges and Opportunities in Vaccine Formulation

In the race for a safe and effective vaccine against coronavirus disease (COVID)-19, pharmaceutical formulation science plays a critical role throughout the development, manufacturing, distribution, and vaccination phases. The proper choice of the type of vaccine, carrier or vector, adjuvant, excipi...

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Detalles Bibliográficos
Autores principales: Wang, Jieliang, Peng, Ying, Xu, Haiyue, Cui, Zhengrong, Williams , Robert O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7405756/
https://www.ncbi.nlm.nih.gov/pubmed/32761294
http://dx.doi.org/10.1208/s12249-020-01744-7
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author Wang, Jieliang
Peng, Ying
Xu, Haiyue
Cui, Zhengrong
Williams , Robert O.
author_facet Wang, Jieliang
Peng, Ying
Xu, Haiyue
Cui, Zhengrong
Williams , Robert O.
author_sort Wang, Jieliang
collection PubMed
description In the race for a safe and effective vaccine against coronavirus disease (COVID)-19, pharmaceutical formulation science plays a critical role throughout the development, manufacturing, distribution, and vaccination phases. The proper choice of the type of vaccine, carrier or vector, adjuvant, excipients, dosage form, and route of administration can directly impact not only the immune responses induced and the resultant efficacy against COVID-19, but also the logistics of manufacturing, storing and distributing the vaccine, and mass vaccination. In this review, we described the COVID-19 vaccines that are currently tested in clinical trials and provided in-depth insight into the various types of vaccines, their compositions, advantages, and potential limitations. We also addressed how challenges in vaccine distribution and administration may be alleviated by applying vaccine-stabilization strategies and the use of specific mucosal immune response-inducing, non-invasive routes of administration, which must be considered early in the development process.
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spelling pubmed-74057562020-08-05 The COVID-19 Vaccine Race: Challenges and Opportunities in Vaccine Formulation Wang, Jieliang Peng, Ying Xu, Haiyue Cui, Zhengrong Williams , Robert O. AAPS PharmSciTech Review Article In the race for a safe and effective vaccine against coronavirus disease (COVID)-19, pharmaceutical formulation science plays a critical role throughout the development, manufacturing, distribution, and vaccination phases. The proper choice of the type of vaccine, carrier or vector, adjuvant, excipients, dosage form, and route of administration can directly impact not only the immune responses induced and the resultant efficacy against COVID-19, but also the logistics of manufacturing, storing and distributing the vaccine, and mass vaccination. In this review, we described the COVID-19 vaccines that are currently tested in clinical trials and provided in-depth insight into the various types of vaccines, their compositions, advantages, and potential limitations. We also addressed how challenges in vaccine distribution and administration may be alleviated by applying vaccine-stabilization strategies and the use of specific mucosal immune response-inducing, non-invasive routes of administration, which must be considered early in the development process. Springer International Publishing 2020-08-05 /pmc/articles/PMC7405756/ /pubmed/32761294 http://dx.doi.org/10.1208/s12249-020-01744-7 Text en © American Association of Pharmaceutical Scientists 2020 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Review Article
Wang, Jieliang
Peng, Ying
Xu, Haiyue
Cui, Zhengrong
Williams , Robert O.
The COVID-19 Vaccine Race: Challenges and Opportunities in Vaccine Formulation
title The COVID-19 Vaccine Race: Challenges and Opportunities in Vaccine Formulation
title_full The COVID-19 Vaccine Race: Challenges and Opportunities in Vaccine Formulation
title_fullStr The COVID-19 Vaccine Race: Challenges and Opportunities in Vaccine Formulation
title_full_unstemmed The COVID-19 Vaccine Race: Challenges and Opportunities in Vaccine Formulation
title_short The COVID-19 Vaccine Race: Challenges and Opportunities in Vaccine Formulation
title_sort covid-19 vaccine race: challenges and opportunities in vaccine formulation
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7405756/
https://www.ncbi.nlm.nih.gov/pubmed/32761294
http://dx.doi.org/10.1208/s12249-020-01744-7
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