Cargando…

Determinants of Quality of Life in Geographic Atrophy Secondary to Age-Related Macular Degeneration

PURPOSE: To longitudinally evaluate vision-related quality of life (VRQoL) in geographic atrophy (GA) secondary to age-related macular degeneration (AMD) and define its relation to visual function and structural biomarkers. METHODS: Patients with GA secondary to AMD were recruited in the context of...

Descripción completa

Detalles Bibliográficos
Autores principales: Künzel, Sandrine H., Möller, Philipp T., Lindner, Moritz, Goerdt, Lukas, Nadal, Jennifer, Schmid, Matthias, Schmitz-Valckenberg, Steffen, Holz, Frank G., Fleckenstein, Monika, Pfau, Maximilian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Association for Research in Vision and Ophthalmology 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7405807/
https://www.ncbi.nlm.nih.gov/pubmed/32462198
http://dx.doi.org/10.1167/iovs.61.5.63
_version_ 1783567323474427904
author Künzel, Sandrine H.
Möller, Philipp T.
Lindner, Moritz
Goerdt, Lukas
Nadal, Jennifer
Schmid, Matthias
Schmitz-Valckenberg, Steffen
Holz, Frank G.
Fleckenstein, Monika
Pfau, Maximilian
author_facet Künzel, Sandrine H.
Möller, Philipp T.
Lindner, Moritz
Goerdt, Lukas
Nadal, Jennifer
Schmid, Matthias
Schmitz-Valckenberg, Steffen
Holz, Frank G.
Fleckenstein, Monika
Pfau, Maximilian
author_sort Künzel, Sandrine H.
collection PubMed
description PURPOSE: To longitudinally evaluate vision-related quality of life (VRQoL) in geographic atrophy (GA) secondary to age-related macular degeneration (AMD) and define its relation to visual function and structural biomarkers. METHODS: Patients with GA secondary to AMD were recruited in the context of the prospective, non-interventional, natural-history Directional Spread in Geographic-Atrophy study (NCT02051998). Fundus autofluorescence and infrared reflectance images were semi-automatically annotated for GA. Linear mixed-effects models were applied to investigate the association of putative determinants with the National Eye Institute Visual Function Questionnaire 25 (NEI VFQ-25) VRQoL. RESULTS: A total of 87 patients with a mean age ± SD of 77.07 ± 7.49 years were included in the analysis. At baseline, median (IQR) best-corrected visual acuity (BCVA) was 0.3 (0.51) for the better eye and 0.89 (0.76) for the worse eye; 46% of the patients showed binocular and 25.3% monocular non-central GA. The VRQoL composite score was impaired: 69.96 (24.03). Sixty-six patients with a median of 2 (2) follow-up visits after 1.08 (0.78) years were examined longitudinally. In the multivariable cross-sectional analysis, predictors of the VRQoL composite score were BCVA, GA size, and low-luminance visual acuity (LLVA) for the better eye and BCVA, foveal sparing status, and LLVA for the worse eye (cross-validated R(2) = 0.32). In the longitudinal analysis, a similar prediction accuracy for VRQoL was determined (cross-validated R(2) = 0.28). Prediction accuracy for VRQoL did not improve when follow-up time was added as an independent variable. CONCLUSIONS: Vision-related quality of life is significantly impaired in patients with GA secondary to AMD. The cross-sectional and longitudinal association of VRQoL with visual functional and structural biomarkers supports the validity of the NEI VFQ-25 VRQoL.
format Online
Article
Text
id pubmed-7405807
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher The Association for Research in Vision and Ophthalmology
record_format MEDLINE/PubMed
spelling pubmed-74058072020-08-19 Determinants of Quality of Life in Geographic Atrophy Secondary to Age-Related Macular Degeneration Künzel, Sandrine H. Möller, Philipp T. Lindner, Moritz Goerdt, Lukas Nadal, Jennifer Schmid, Matthias Schmitz-Valckenberg, Steffen Holz, Frank G. Fleckenstein, Monika Pfau, Maximilian Invest Ophthalmol Vis Sci Low Vision PURPOSE: To longitudinally evaluate vision-related quality of life (VRQoL) in geographic atrophy (GA) secondary to age-related macular degeneration (AMD) and define its relation to visual function and structural biomarkers. METHODS: Patients with GA secondary to AMD were recruited in the context of the prospective, non-interventional, natural-history Directional Spread in Geographic-Atrophy study (NCT02051998). Fundus autofluorescence and infrared reflectance images were semi-automatically annotated for GA. Linear mixed-effects models were applied to investigate the association of putative determinants with the National Eye Institute Visual Function Questionnaire 25 (NEI VFQ-25) VRQoL. RESULTS: A total of 87 patients with a mean age ± SD of 77.07 ± 7.49 years were included in the analysis. At baseline, median (IQR) best-corrected visual acuity (BCVA) was 0.3 (0.51) for the better eye and 0.89 (0.76) for the worse eye; 46% of the patients showed binocular and 25.3% monocular non-central GA. The VRQoL composite score was impaired: 69.96 (24.03). Sixty-six patients with a median of 2 (2) follow-up visits after 1.08 (0.78) years were examined longitudinally. In the multivariable cross-sectional analysis, predictors of the VRQoL composite score were BCVA, GA size, and low-luminance visual acuity (LLVA) for the better eye and BCVA, foveal sparing status, and LLVA for the worse eye (cross-validated R(2) = 0.32). In the longitudinal analysis, a similar prediction accuracy for VRQoL was determined (cross-validated R(2) = 0.28). Prediction accuracy for VRQoL did not improve when follow-up time was added as an independent variable. CONCLUSIONS: Vision-related quality of life is significantly impaired in patients with GA secondary to AMD. The cross-sectional and longitudinal association of VRQoL with visual functional and structural biomarkers supports the validity of the NEI VFQ-25 VRQoL. The Association for Research in Vision and Ophthalmology 2020-05-27 /pmc/articles/PMC7405807/ /pubmed/32462198 http://dx.doi.org/10.1167/iovs.61.5.63 Text en Copyright 2020 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
spellingShingle Low Vision
Künzel, Sandrine H.
Möller, Philipp T.
Lindner, Moritz
Goerdt, Lukas
Nadal, Jennifer
Schmid, Matthias
Schmitz-Valckenberg, Steffen
Holz, Frank G.
Fleckenstein, Monika
Pfau, Maximilian
Determinants of Quality of Life in Geographic Atrophy Secondary to Age-Related Macular Degeneration
title Determinants of Quality of Life in Geographic Atrophy Secondary to Age-Related Macular Degeneration
title_full Determinants of Quality of Life in Geographic Atrophy Secondary to Age-Related Macular Degeneration
title_fullStr Determinants of Quality of Life in Geographic Atrophy Secondary to Age-Related Macular Degeneration
title_full_unstemmed Determinants of Quality of Life in Geographic Atrophy Secondary to Age-Related Macular Degeneration
title_short Determinants of Quality of Life in Geographic Atrophy Secondary to Age-Related Macular Degeneration
title_sort determinants of quality of life in geographic atrophy secondary to age-related macular degeneration
topic Low Vision
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7405807/
https://www.ncbi.nlm.nih.gov/pubmed/32462198
http://dx.doi.org/10.1167/iovs.61.5.63
work_keys_str_mv AT kunzelsandrineh determinantsofqualityoflifeingeographicatrophysecondarytoagerelatedmaculardegeneration
AT mollerphilippt determinantsofqualityoflifeingeographicatrophysecondarytoagerelatedmaculardegeneration
AT lindnermoritz determinantsofqualityoflifeingeographicatrophysecondarytoagerelatedmaculardegeneration
AT goerdtlukas determinantsofqualityoflifeingeographicatrophysecondarytoagerelatedmaculardegeneration
AT nadaljennifer determinantsofqualityoflifeingeographicatrophysecondarytoagerelatedmaculardegeneration
AT schmidmatthias determinantsofqualityoflifeingeographicatrophysecondarytoagerelatedmaculardegeneration
AT schmitzvalckenbergsteffen determinantsofqualityoflifeingeographicatrophysecondarytoagerelatedmaculardegeneration
AT holzfrankg determinantsofqualityoflifeingeographicatrophysecondarytoagerelatedmaculardegeneration
AT fleckensteinmonika determinantsofqualityoflifeingeographicatrophysecondarytoagerelatedmaculardegeneration
AT pfaumaximilian determinantsofqualityoflifeingeographicatrophysecondarytoagerelatedmaculardegeneration