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Development and simulation of fully glycosylated molecular models of ACE2-Fc fusion proteins and their interaction with the SARS-CoV-2 spike protein binding domain
We develop fully glycosylated computational models of ACE2-Fc fusion proteins which are promising targets for a COVID-19 therapeutic. These models are tested in their interaction with a fragment of the receptor-binding domain (RBD) of the Spike Protein S of the SARS-CoV-2 virus, via atomistic molecu...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7406073/ https://www.ncbi.nlm.nih.gov/pubmed/32756606 http://dx.doi.org/10.1371/journal.pone.0237295 |
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author | Bernardi, Austen Huang, Yihan Harris, Bradley Xiong, Yongao Nandi, Somen McDonald, Karen A. Faller, Roland |
author_facet | Bernardi, Austen Huang, Yihan Harris, Bradley Xiong, Yongao Nandi, Somen McDonald, Karen A. Faller, Roland |
author_sort | Bernardi, Austen |
collection | PubMed |
description | We develop fully glycosylated computational models of ACE2-Fc fusion proteins which are promising targets for a COVID-19 therapeutic. These models are tested in their interaction with a fragment of the receptor-binding domain (RBD) of the Spike Protein S of the SARS-CoV-2 virus, via atomistic molecular dynamics simulations. We see that some ACE2 glycans interact with the S fragments, and glycans are influencing the conformation of the ACE2 receptor. Additionally, we optimize algorithms for protein glycosylation modelling in order to expedite future model development. All models and algorithms are openly available. |
format | Online Article Text |
id | pubmed-7406073 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-74060732020-08-13 Development and simulation of fully glycosylated molecular models of ACE2-Fc fusion proteins and their interaction with the SARS-CoV-2 spike protein binding domain Bernardi, Austen Huang, Yihan Harris, Bradley Xiong, Yongao Nandi, Somen McDonald, Karen A. Faller, Roland PLoS One Research Article We develop fully glycosylated computational models of ACE2-Fc fusion proteins which are promising targets for a COVID-19 therapeutic. These models are tested in their interaction with a fragment of the receptor-binding domain (RBD) of the Spike Protein S of the SARS-CoV-2 virus, via atomistic molecular dynamics simulations. We see that some ACE2 glycans interact with the S fragments, and glycans are influencing the conformation of the ACE2 receptor. Additionally, we optimize algorithms for protein glycosylation modelling in order to expedite future model development. All models and algorithms are openly available. Public Library of Science 2020-08-05 /pmc/articles/PMC7406073/ /pubmed/32756606 http://dx.doi.org/10.1371/journal.pone.0237295 Text en © 2020 Bernardi et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Bernardi, Austen Huang, Yihan Harris, Bradley Xiong, Yongao Nandi, Somen McDonald, Karen A. Faller, Roland Development and simulation of fully glycosylated molecular models of ACE2-Fc fusion proteins and their interaction with the SARS-CoV-2 spike protein binding domain |
title | Development and simulation of fully glycosylated molecular models of ACE2-Fc fusion proteins and their interaction with the SARS-CoV-2 spike protein binding domain |
title_full | Development and simulation of fully glycosylated molecular models of ACE2-Fc fusion proteins and their interaction with the SARS-CoV-2 spike protein binding domain |
title_fullStr | Development and simulation of fully glycosylated molecular models of ACE2-Fc fusion proteins and their interaction with the SARS-CoV-2 spike protein binding domain |
title_full_unstemmed | Development and simulation of fully glycosylated molecular models of ACE2-Fc fusion proteins and their interaction with the SARS-CoV-2 spike protein binding domain |
title_short | Development and simulation of fully glycosylated molecular models of ACE2-Fc fusion proteins and their interaction with the SARS-CoV-2 spike protein binding domain |
title_sort | development and simulation of fully glycosylated molecular models of ace2-fc fusion proteins and their interaction with the sars-cov-2 spike protein binding domain |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7406073/ https://www.ncbi.nlm.nih.gov/pubmed/32756606 http://dx.doi.org/10.1371/journal.pone.0237295 |
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