Development and simulation of fully glycosylated molecular models of ACE2-Fc fusion proteins and their interaction with the SARS-CoV-2 spike protein binding domain

We develop fully glycosylated computational models of ACE2-Fc fusion proteins which are promising targets for a COVID-19 therapeutic. These models are tested in their interaction with a fragment of the receptor-binding domain (RBD) of the Spike Protein S of the SARS-CoV-2 virus, via atomistic molecu...

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Detalles Bibliográficos
Autores principales: Bernardi, Austen, Huang, Yihan, Harris, Bradley, Xiong, Yongao, Nandi, Somen, McDonald, Karen A., Faller, Roland
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7406073/
https://www.ncbi.nlm.nih.gov/pubmed/32756606
http://dx.doi.org/10.1371/journal.pone.0237295

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