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Relaxin-expressing oncolytic adenovirus induces remodeling of physical and immunological aspects of cold tumor to potentiate PD-1 blockade

BACKGROUND: Currently, several antibody (Ab)-based therapies have shown excellent therapeutic effects in the clinic. Nonetheless, Ab penetration into tumor tissues is limited due to abnormal vasculature, tumor interstitial pressure, and excessive extracellular matrix (ECM) accumulation, thus demandi...

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Detalles Bibliográficos
Autores principales:	Jung, Bo-Kyeong, Ko, Hae Young, Kang, Hyunji, Hong, JinWoo, Ahn, Hyo Min, Na, Youjin, Kim, Hyeongi, Kim, Jin Su, Yun, Chae-Ok
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2020
Materias:	Oncolytic and Local Immunotherapy
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7406118/ https://www.ncbi.nlm.nih.gov/pubmed/32753544 http://dx.doi.org/10.1136/jitc-2020-000763

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