Targeting HIV Env immunogens to B cell follicles in nonhuman primates through immune complex or protein nanoparticle formulations

Following immunization, high-affinity antibody responses develop within germinal centers (GCs), specialized sites within follicles of the lymph node (LN) where B cells proliferate and undergo somatic hypermutation. Antigen availability within GCs is important, as B cells must acquire and present ant...

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Detalles Bibliográficos
Autores principales: Martin, Jacob T., Cottrell, Christopher A., Antanasijevic, Aleksandar, Carnathan, Diane G., Cossette, Benjamin J., Enemuo, Chiamaka A., Gebru, Etse H., Choe, Yury, Viviano, Federico, Fischinger, Stephanie, Tokatlian, Talar, Cirelli, Kimberly M., Ueda, George, Copps, Jeffrey, Schiffner, Torben, Menis, Sergey, Alter, Galit, Schief, William R., Crotty, Shane, King, Neil P., Baker, David, Silvestri, Guido, Ward, Andrew B., Irvine, Darrell J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7406516/
https://www.ncbi.nlm.nih.gov/pubmed/32802411
http://dx.doi.org/10.1038/s41541-020-00223-1

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