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Reversal of Alpha-Synuclein Fibrillization by Protein Disulfide Isomerase

Aggregates of α-synuclein contribute to the etiology of Parkinson’s Disease. Protein disulfide isomerase (PDI), a chaperone and oxidoreductase, blocks the aggregation of α-synuclein. An S-nitrosylated form of PDI that cannot function as a chaperone is associated with elevated levels of aggregated α-...

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Detalles Bibliográficos
Autores principales:	Serrano, Albert, Qiao, Xin, Matos, Jason O., Farley, Lauren, Cilenti, Lucia, Chen, Bo, Tatulian, Suren A., Teter, Ken
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2020
Materias:	Cell and Developmental Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7406567/ https://www.ncbi.nlm.nih.gov/pubmed/32850841 http://dx.doi.org/10.3389/fcell.2020.00726

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