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Accumulation of Asn450Tyr mutant myocilin in ER promotes apoptosis of human trabecular meshwork cells

PURPOSE: In a previous study, we identified the Asn450Tyr mutant myocilin gene (Myoc-N450Y) in the pedigree of families with juvenile open angle glaucoma (JOAG), but whether N450Y is a pathogenic mutation remained to be determined. The present study aimed at exploring the role of Myoc-N450Y in prima...

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Detalles Bibliográficos
Autores principales:	Yan, Xuejing, Wu, Shen, Liu, Qian, Li, Yang, Zhu, Wei, Zhang, Jingxue
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Molecular Vision 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7406863/ https://www.ncbi.nlm.nih.gov/pubmed/32818018

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