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The relationship between oxidative stress and preeclampsia. The serum ischemia-modified albumin levels and thiol/disulfide homeostasis
OBJECTIVE: Preeclampsia (PE) is a dangerous complication of pregnancy and still a major cause of maternal-fetal morbidity and mortality. Its etiology remains largely unknown, but researchers have suggested oxidative stress-mediated inflammation for the same. The purpose of this study is to investiga...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Galenos Publishing
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7406905/ https://www.ncbi.nlm.nih.gov/pubmed/32850184 http://dx.doi.org/10.4274/tjod.galenos.2020.23682 |
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author | Onat, Taylan Aydoğan Kırmızı, Demet Başer, Emre Ercan, Müjgan Demir Çaltekin, Melike Yalçın, Serenat Kara, Mustafa Esinler, Deniz Yalvaç, Ethem Serdar |
author_facet | Onat, Taylan Aydoğan Kırmızı, Demet Başer, Emre Ercan, Müjgan Demir Çaltekin, Melike Yalçın, Serenat Kara, Mustafa Esinler, Deniz Yalvaç, Ethem Serdar |
author_sort | Onat, Taylan |
collection | PubMed |
description | OBJECTIVE: Preeclampsia (PE) is a dangerous complication of pregnancy and still a major cause of maternal-fetal morbidity and mortality. Its etiology remains largely unknown, but researchers have suggested oxidative stress-mediated inflammation for the same. The purpose of this study is to investigate the relationship between oxidative stress and PE as well as the usability of oxidative stress indicators such as serum ischemia-modified albumin (IMA) levels and thiol/disulfide balance in the prediction of PE. MATERIALS AND METHODS: The study included 47 pregnant women with PE and 57 healthy pregnant women. We measured their serum IMA, native thiol, total thiol, and disulfide levels. Additionally, we determined the optimal cutoff values via the receiver operating characteristic curve analysis. RESULTS: There were no differences between the two groups with respect to the maternal age, body mass index, gravida, and parity. The native and total thiol levels were found to be low when the disulfide and IMA levels were high in the patients with PE (p<0.05). When the IMA level was corrected by the albumin level (IMAR), the significant difference between the two groups disappeared. We also found that the native and total thiol concentrations were correlated with the systolic and diastolic blood pressures. The optimal cut-off values calculated for the prediction of PE were as follows: 178.45 µmol/L (with sensitivity of 72% and specificity of 83%) for native thiol, 232.55 µ mol/L (with a sensitivity of 75% and specificity of 85%) for total thiol, and 29.05 µmol/L (with sensitivity of 65% and specificity of 72%) for disulfide. CONCLUSION: The balance of thiol/disulfide may play a role in the pathogenesis of PE and could be used as a biological marker for PE. |
format | Online Article Text |
id | pubmed-7406905 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Galenos Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-74069052020-08-25 The relationship between oxidative stress and preeclampsia. The serum ischemia-modified albumin levels and thiol/disulfide homeostasis Onat, Taylan Aydoğan Kırmızı, Demet Başer, Emre Ercan, Müjgan Demir Çaltekin, Melike Yalçın, Serenat Kara, Mustafa Esinler, Deniz Yalvaç, Ethem Serdar Turk J Obstet Gynecol Clinical Investigation OBJECTIVE: Preeclampsia (PE) is a dangerous complication of pregnancy and still a major cause of maternal-fetal morbidity and mortality. Its etiology remains largely unknown, but researchers have suggested oxidative stress-mediated inflammation for the same. The purpose of this study is to investigate the relationship between oxidative stress and PE as well as the usability of oxidative stress indicators such as serum ischemia-modified albumin (IMA) levels and thiol/disulfide balance in the prediction of PE. MATERIALS AND METHODS: The study included 47 pregnant women with PE and 57 healthy pregnant women. We measured their serum IMA, native thiol, total thiol, and disulfide levels. Additionally, we determined the optimal cutoff values via the receiver operating characteristic curve analysis. RESULTS: There were no differences between the two groups with respect to the maternal age, body mass index, gravida, and parity. The native and total thiol levels were found to be low when the disulfide and IMA levels were high in the patients with PE (p<0.05). When the IMA level was corrected by the albumin level (IMAR), the significant difference between the two groups disappeared. We also found that the native and total thiol concentrations were correlated with the systolic and diastolic blood pressures. The optimal cut-off values calculated for the prediction of PE were as follows: 178.45 µmol/L (with sensitivity of 72% and specificity of 83%) for native thiol, 232.55 µ mol/L (with a sensitivity of 75% and specificity of 85%) for total thiol, and 29.05 µmol/L (with sensitivity of 65% and specificity of 72%) for disulfide. CONCLUSION: The balance of thiol/disulfide may play a role in the pathogenesis of PE and could be used as a biological marker for PE. Galenos Publishing 2020-06 2020-07-29 /pmc/articles/PMC7406905/ /pubmed/32850184 http://dx.doi.org/10.4274/tjod.galenos.2020.23682 Text en ©Copyright 2020 by Turkish Society of Obstetrics and Gynecology | Turkish Journal of Obstetrics and Gynecology published by Galenos Publishing House. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Clinical Investigation Onat, Taylan Aydoğan Kırmızı, Demet Başer, Emre Ercan, Müjgan Demir Çaltekin, Melike Yalçın, Serenat Kara, Mustafa Esinler, Deniz Yalvaç, Ethem Serdar The relationship between oxidative stress and preeclampsia. The serum ischemia-modified albumin levels and thiol/disulfide homeostasis |
title | The relationship between oxidative stress and preeclampsia. The serum ischemia-modified albumin levels and thiol/disulfide homeostasis |
title_full | The relationship between oxidative stress and preeclampsia. The serum ischemia-modified albumin levels and thiol/disulfide homeostasis |
title_fullStr | The relationship between oxidative stress and preeclampsia. The serum ischemia-modified albumin levels and thiol/disulfide homeostasis |
title_full_unstemmed | The relationship between oxidative stress and preeclampsia. The serum ischemia-modified albumin levels and thiol/disulfide homeostasis |
title_short | The relationship between oxidative stress and preeclampsia. The serum ischemia-modified albumin levels and thiol/disulfide homeostasis |
title_sort | relationship between oxidative stress and preeclampsia. the serum ischemia-modified albumin levels and thiol/disulfide homeostasis |
topic | Clinical Investigation |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7406905/ https://www.ncbi.nlm.nih.gov/pubmed/32850184 http://dx.doi.org/10.4274/tjod.galenos.2020.23682 |
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