Re‐establishing indwelling pleural catheter patency with alteplase after failure of streptokinase

Indwelling pleural catheter (IPC) has revolutionized the management of malignant pleural effusion (MPE). IPC is relatively safe, although complications can occur. We report a 53‐year‐old woman with stage IVA lung adenocarcinoma and recurrent MPE. Two months post insertion, the IPC was blocked with r...

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Autores principales: Faisal, Mohamed, Nurhanis, Siti, Nik Abeed, Nik Nuratiqah, Ng, Boon Hau, Ban, Andrea Yu‐Lin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Ltd 2020
Materias:
Case Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7406907/
https://www.ncbi.nlm.nih.gov/pubmed/32774860
http://dx.doi.org/10.1002/rcr2.639
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author Faisal, Mohamed
Nurhanis, Siti
Nik Abeed, Nik Nuratiqah
Ng, Boon Hau
Ban, Andrea Yu‐Lin
author_facet Faisal, Mohamed
Nurhanis, Siti
Nik Abeed, Nik Nuratiqah
Ng, Boon Hau
Ban, Andrea Yu‐Lin
author_sort Faisal, Mohamed
collection PubMed
description Indwelling pleural catheter (IPC) has revolutionized the management of malignant pleural effusion (MPE). IPC is relatively safe, although complications can occur. We report a 53‐year‐old woman with stage IVA lung adenocarcinoma and recurrent MPE. Two months post insertion, the IPC was blocked with residual effusion and presence of new loculations. Attempts to restore patency with six doses of intrapleural (IP) streptokinase failed. She was referred to our centre for further management. We used a single dose of 2.5 mg IP alteplase which was successful in establishing patency of the IPC and draining the effusion. This case highlights the safety and efficacy of IP alteplase via IPC following a failed instillation of streptokinase.
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spelling pubmed-74069072020-08-07 Re‐establishing indwelling pleural catheter patency with alteplase after failure of streptokinase Faisal, Mohamed Nurhanis, Siti Nik Abeed, Nik Nuratiqah Ng, Boon Hau Ban, Andrea Yu‐Lin Respirol Case Rep Case Reports Indwelling pleural catheter (IPC) has revolutionized the management of malignant pleural effusion (MPE). IPC is relatively safe, although complications can occur. We report a 53‐year‐old woman with stage IVA lung adenocarcinoma and recurrent MPE. Two months post insertion, the IPC was blocked with residual effusion and presence of new loculations. Attempts to restore patency with six doses of intrapleural (IP) streptokinase failed. She was referred to our centre for further management. We used a single dose of 2.5 mg IP alteplase which was successful in establishing patency of the IPC and draining the effusion. This case highlights the safety and efficacy of IP alteplase via IPC following a failed instillation of streptokinase. John Wiley & Sons, Ltd 2020-08-06 /pmc/articles/PMC7406907/ /pubmed/32774860 http://dx.doi.org/10.1002/rcr2.639 Text en © 2020 The Authors. Respirology Case Reports published by John Wiley & Sons Australia, Ltd on behalf of The Asian Pacific Society of Respirology. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Reports
Faisal, Mohamed
Nurhanis, Siti
Nik Abeed, Nik Nuratiqah
Ng, Boon Hau
Ban, Andrea Yu‐Lin
Re‐establishing indwelling pleural catheter patency with alteplase after failure of streptokinase
title Re‐establishing indwelling pleural catheter patency with alteplase after failure of streptokinase
title_full Re‐establishing indwelling pleural catheter patency with alteplase after failure of streptokinase
title_fullStr Re‐establishing indwelling pleural catheter patency with alteplase after failure of streptokinase
title_full_unstemmed Re‐establishing indwelling pleural catheter patency with alteplase after failure of streptokinase
title_short Re‐establishing indwelling pleural catheter patency with alteplase after failure of streptokinase
title_sort re‐establishing indwelling pleural catheter patency with alteplase after failure of streptokinase
topic Case Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7406907/
https://www.ncbi.nlm.nih.gov/pubmed/32774860
http://dx.doi.org/10.1002/rcr2.639
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