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Magnetic resonance-guided high-intensity focused ultrasound of uterine fibroids: whole-tumor quantitative perfusion for prediction of immediate ablation response
BACKGROUND: In magnetic resonance-guided high-intensity focused ultrasound (MR-HIFU) treatment of uterine fibroids, the immediate ablation response is significantly affected by blood perfusion. The variability of measurement for blood perfusion is critical due to the inherent non-uniformity of tumor...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7406966/ https://www.ncbi.nlm.nih.gov/pubmed/31779469 http://dx.doi.org/10.1177/0284185119891692 |
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author | Li, Chenxia Jin, Chao Liang, Ting Li, Xiang Wang, Rong Zhang, Yuelang Yang, Jian |
author_facet | Li, Chenxia Jin, Chao Liang, Ting Li, Xiang Wang, Rong Zhang, Yuelang Yang, Jian |
author_sort | Li, Chenxia |
collection | PubMed |
description | BACKGROUND: In magnetic resonance-guided high-intensity focused ultrasound (MR-HIFU) treatment of uterine fibroids, the immediate ablation response is significantly affected by blood perfusion. The variability of measurement for blood perfusion is critical due to the inherent non-uniformity of tumor perfusion and its dependence on reproducible region of interest (ROI) placement. PURPOSE: To investigate the value of whole-tumor ROI (ROIwt) analysis for quantitative perfusion in predicting immediate ablation response of uterine fibroids in MR-HIFU. MATERIAL AND METHODS: Thirty-one fibroids in 28 eligible patients were treated with MR-HIFU. Quantitative perfusion parameters (K(trans), K(ep), and V(p)) derived from dynamic contrast-enhanced MRI were obtained before MR-HIFU treatment. The ROIwt and single-layer ROI (ROIsl) were used for quantitative perfusion analysis. T1 contrast-enhanced MRI immediately after MR-HIFU treatment was conducted to determine the non-perfused volume ratio (NPVR). Intraclass correlation coefficient (ICC) was used for consistency test. Spearman’s correlation and multivariate linear regression were used to investigate the predictors of the NPVR. Received operating characteristic (ROC) curve was used to test the predictive efficacy of quantitative perfusion parameter. RESULTS: The intra- and inter-observer ICC of the quantitative perfusion parameters from ROIwt were higher than those from ROIsl. Multivariate analysis showed that the K(trans) of ROIwt was a predictor of the immediate ablation response. ROC analysis displayed that the AUC of K(trans) of ROIwt is 0.817 in predicting the ablation response. CONCLUSION: Pretreatment K(trans) of ROIwt is more reliable and stable than that of ROIsl. It could be a predictor for the immediate ablation response of uterine fibroids in MR-HIFU. |
format | Online Article Text |
id | pubmed-7406966 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-74069662020-08-19 Magnetic resonance-guided high-intensity focused ultrasound of uterine fibroids: whole-tumor quantitative perfusion for prediction of immediate ablation response Li, Chenxia Jin, Chao Liang, Ting Li, Xiang Wang, Rong Zhang, Yuelang Yang, Jian Acta Radiol Urogenital Radiology BACKGROUND: In magnetic resonance-guided high-intensity focused ultrasound (MR-HIFU) treatment of uterine fibroids, the immediate ablation response is significantly affected by blood perfusion. The variability of measurement for blood perfusion is critical due to the inherent non-uniformity of tumor perfusion and its dependence on reproducible region of interest (ROI) placement. PURPOSE: To investigate the value of whole-tumor ROI (ROIwt) analysis for quantitative perfusion in predicting immediate ablation response of uterine fibroids in MR-HIFU. MATERIAL AND METHODS: Thirty-one fibroids in 28 eligible patients were treated with MR-HIFU. Quantitative perfusion parameters (K(trans), K(ep), and V(p)) derived from dynamic contrast-enhanced MRI were obtained before MR-HIFU treatment. The ROIwt and single-layer ROI (ROIsl) were used for quantitative perfusion analysis. T1 contrast-enhanced MRI immediately after MR-HIFU treatment was conducted to determine the non-perfused volume ratio (NPVR). Intraclass correlation coefficient (ICC) was used for consistency test. Spearman’s correlation and multivariate linear regression were used to investigate the predictors of the NPVR. Received operating characteristic (ROC) curve was used to test the predictive efficacy of quantitative perfusion parameter. RESULTS: The intra- and inter-observer ICC of the quantitative perfusion parameters from ROIwt were higher than those from ROIsl. Multivariate analysis showed that the K(trans) of ROIwt was a predictor of the immediate ablation response. ROC analysis displayed that the AUC of K(trans) of ROIwt is 0.817 in predicting the ablation response. CONCLUSION: Pretreatment K(trans) of ROIwt is more reliable and stable than that of ROIsl. It could be a predictor for the immediate ablation response of uterine fibroids in MR-HIFU. SAGE Publications 2019-11-28 2020-08 /pmc/articles/PMC7406966/ /pubmed/31779469 http://dx.doi.org/10.1177/0284185119891692 Text en © The Foundation Acta Radiologica 2019 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Urogenital Radiology Li, Chenxia Jin, Chao Liang, Ting Li, Xiang Wang, Rong Zhang, Yuelang Yang, Jian Magnetic resonance-guided high-intensity focused ultrasound of uterine fibroids: whole-tumor quantitative perfusion for prediction of immediate ablation response |
title | Magnetic resonance-guided high-intensity focused ultrasound of uterine fibroids: whole-tumor quantitative perfusion for prediction of immediate ablation response |
title_full | Magnetic resonance-guided high-intensity focused ultrasound of uterine fibroids: whole-tumor quantitative perfusion for prediction of immediate ablation response |
title_fullStr | Magnetic resonance-guided high-intensity focused ultrasound of uterine fibroids: whole-tumor quantitative perfusion for prediction of immediate ablation response |
title_full_unstemmed | Magnetic resonance-guided high-intensity focused ultrasound of uterine fibroids: whole-tumor quantitative perfusion for prediction of immediate ablation response |
title_short | Magnetic resonance-guided high-intensity focused ultrasound of uterine fibroids: whole-tumor quantitative perfusion for prediction of immediate ablation response |
title_sort | magnetic resonance-guided high-intensity focused ultrasound of uterine fibroids: whole-tumor quantitative perfusion for prediction of immediate ablation response |
topic | Urogenital Radiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7406966/ https://www.ncbi.nlm.nih.gov/pubmed/31779469 http://dx.doi.org/10.1177/0284185119891692 |
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