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Accelerated Kidney Aging in Diabetes Mellitus
With aging, the kidney undergoes inexorable and progressive changes in structural and functional performance. These aging-related alterations are more obvious and serious in diabetes mellitus (DM). Renal accelerated aging under DM conditions is associated with multiple stresses such as accumulation...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7407029/ https://www.ncbi.nlm.nih.gov/pubmed/32774664 http://dx.doi.org/10.1155/2020/1234059 |
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author | Guo, Jing Zheng, Hui Juan Zhang, Wenting Lou, Wenjiao Xia, Chenhui Han, Xue Ting Huang, Wei Jun Zhang, Fan Wang, Yaoxian Liu, Wei Jing |
author_facet | Guo, Jing Zheng, Hui Juan Zhang, Wenting Lou, Wenjiao Xia, Chenhui Han, Xue Ting Huang, Wei Jun Zhang, Fan Wang, Yaoxian Liu, Wei Jing |
author_sort | Guo, Jing |
collection | PubMed |
description | With aging, the kidney undergoes inexorable and progressive changes in structural and functional performance. These aging-related alterations are more obvious and serious in diabetes mellitus (DM). Renal accelerated aging under DM conditions is associated with multiple stresses such as accumulation of advanced glycation end products (AGEs), hypertension, oxidative stress, and inflammation. The main hallmarks of cellular senescence in diabetic kidneys include cyclin-dependent kinase inhibitors, telomere shortening, and diabetic nephropathy-associated secretory phenotype. Lysosome-dependent autophagy and antiaging proteins Klotho and Sirt1 play a fundamental role in the accelerated aging of kidneys in DM, among which the autophagy-lysosome system is the convergent mechanism of the multiple antiaging pathways involved in renal aging under DM conditions. Metformin and the inhibitor of sodium–glucose cotransporter 2 are recommended due to their antiaging effects independent of antihyperglycemia, besides angiotensin-converting enzyme inhibitors/angiotensin receptor blockers. Additionally, diet intervention including low protein and low AGEs with antioxidants are suggested for patients with diabetic nephropathy (DN). However, their long-term benefits still need further study. Exploring the interactive relationships among antiaging protein Klotho, Sirt1, and autophagy-lysosome system may provide insight into better satisfying the urgent medical needs of elderly patients with aging-related DN. |
format | Online Article Text |
id | pubmed-7407029 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-74070292020-08-07 Accelerated Kidney Aging in Diabetes Mellitus Guo, Jing Zheng, Hui Juan Zhang, Wenting Lou, Wenjiao Xia, Chenhui Han, Xue Ting Huang, Wei Jun Zhang, Fan Wang, Yaoxian Liu, Wei Jing Oxid Med Cell Longev Review Article With aging, the kidney undergoes inexorable and progressive changes in structural and functional performance. These aging-related alterations are more obvious and serious in diabetes mellitus (DM). Renal accelerated aging under DM conditions is associated with multiple stresses such as accumulation of advanced glycation end products (AGEs), hypertension, oxidative stress, and inflammation. The main hallmarks of cellular senescence in diabetic kidneys include cyclin-dependent kinase inhibitors, telomere shortening, and diabetic nephropathy-associated secretory phenotype. Lysosome-dependent autophagy and antiaging proteins Klotho and Sirt1 play a fundamental role in the accelerated aging of kidneys in DM, among which the autophagy-lysosome system is the convergent mechanism of the multiple antiaging pathways involved in renal aging under DM conditions. Metformin and the inhibitor of sodium–glucose cotransporter 2 are recommended due to their antiaging effects independent of antihyperglycemia, besides angiotensin-converting enzyme inhibitors/angiotensin receptor blockers. Additionally, diet intervention including low protein and low AGEs with antioxidants are suggested for patients with diabetic nephropathy (DN). However, their long-term benefits still need further study. Exploring the interactive relationships among antiaging protein Klotho, Sirt1, and autophagy-lysosome system may provide insight into better satisfying the urgent medical needs of elderly patients with aging-related DN. Hindawi 2020-07-27 /pmc/articles/PMC7407029/ /pubmed/32774664 http://dx.doi.org/10.1155/2020/1234059 Text en Copyright © 2020 Jing Guo et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Guo, Jing Zheng, Hui Juan Zhang, Wenting Lou, Wenjiao Xia, Chenhui Han, Xue Ting Huang, Wei Jun Zhang, Fan Wang, Yaoxian Liu, Wei Jing Accelerated Kidney Aging in Diabetes Mellitus |
title | Accelerated Kidney Aging in Diabetes Mellitus |
title_full | Accelerated Kidney Aging in Diabetes Mellitus |
title_fullStr | Accelerated Kidney Aging in Diabetes Mellitus |
title_full_unstemmed | Accelerated Kidney Aging in Diabetes Mellitus |
title_short | Accelerated Kidney Aging in Diabetes Mellitus |
title_sort | accelerated kidney aging in diabetes mellitus |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7407029/ https://www.ncbi.nlm.nih.gov/pubmed/32774664 http://dx.doi.org/10.1155/2020/1234059 |
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