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Accelerated Kidney Aging in Diabetes Mellitus

With aging, the kidney undergoes inexorable and progressive changes in structural and functional performance. These aging-related alterations are more obvious and serious in diabetes mellitus (DM). Renal accelerated aging under DM conditions is associated with multiple stresses such as accumulation...

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Autores principales: Guo, Jing, Zheng, Hui Juan, Zhang, Wenting, Lou, Wenjiao, Xia, Chenhui, Han, Xue Ting, Huang, Wei Jun, Zhang, Fan, Wang, Yaoxian, Liu, Wei Jing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7407029/
https://www.ncbi.nlm.nih.gov/pubmed/32774664
http://dx.doi.org/10.1155/2020/1234059
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author Guo, Jing
Zheng, Hui Juan
Zhang, Wenting
Lou, Wenjiao
Xia, Chenhui
Han, Xue Ting
Huang, Wei Jun
Zhang, Fan
Wang, Yaoxian
Liu, Wei Jing
author_facet Guo, Jing
Zheng, Hui Juan
Zhang, Wenting
Lou, Wenjiao
Xia, Chenhui
Han, Xue Ting
Huang, Wei Jun
Zhang, Fan
Wang, Yaoxian
Liu, Wei Jing
author_sort Guo, Jing
collection PubMed
description With aging, the kidney undergoes inexorable and progressive changes in structural and functional performance. These aging-related alterations are more obvious and serious in diabetes mellitus (DM). Renal accelerated aging under DM conditions is associated with multiple stresses such as accumulation of advanced glycation end products (AGEs), hypertension, oxidative stress, and inflammation. The main hallmarks of cellular senescence in diabetic kidneys include cyclin-dependent kinase inhibitors, telomere shortening, and diabetic nephropathy-associated secretory phenotype. Lysosome-dependent autophagy and antiaging proteins Klotho and Sirt1 play a fundamental role in the accelerated aging of kidneys in DM, among which the autophagy-lysosome system is the convergent mechanism of the multiple antiaging pathways involved in renal aging under DM conditions. Metformin and the inhibitor of sodium–glucose cotransporter 2 are recommended due to their antiaging effects independent of antihyperglycemia, besides angiotensin-converting enzyme inhibitors/angiotensin receptor blockers. Additionally, diet intervention including low protein and low AGEs with antioxidants are suggested for patients with diabetic nephropathy (DN). However, their long-term benefits still need further study. Exploring the interactive relationships among antiaging protein Klotho, Sirt1, and autophagy-lysosome system may provide insight into better satisfying the urgent medical needs of elderly patients with aging-related DN.
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spelling pubmed-74070292020-08-07 Accelerated Kidney Aging in Diabetes Mellitus Guo, Jing Zheng, Hui Juan Zhang, Wenting Lou, Wenjiao Xia, Chenhui Han, Xue Ting Huang, Wei Jun Zhang, Fan Wang, Yaoxian Liu, Wei Jing Oxid Med Cell Longev Review Article With aging, the kidney undergoes inexorable and progressive changes in structural and functional performance. These aging-related alterations are more obvious and serious in diabetes mellitus (DM). Renal accelerated aging under DM conditions is associated with multiple stresses such as accumulation of advanced glycation end products (AGEs), hypertension, oxidative stress, and inflammation. The main hallmarks of cellular senescence in diabetic kidneys include cyclin-dependent kinase inhibitors, telomere shortening, and diabetic nephropathy-associated secretory phenotype. Lysosome-dependent autophagy and antiaging proteins Klotho and Sirt1 play a fundamental role in the accelerated aging of kidneys in DM, among which the autophagy-lysosome system is the convergent mechanism of the multiple antiaging pathways involved in renal aging under DM conditions. Metformin and the inhibitor of sodium–glucose cotransporter 2 are recommended due to their antiaging effects independent of antihyperglycemia, besides angiotensin-converting enzyme inhibitors/angiotensin receptor blockers. Additionally, diet intervention including low protein and low AGEs with antioxidants are suggested for patients with diabetic nephropathy (DN). However, their long-term benefits still need further study. Exploring the interactive relationships among antiaging protein Klotho, Sirt1, and autophagy-lysosome system may provide insight into better satisfying the urgent medical needs of elderly patients with aging-related DN. Hindawi 2020-07-27 /pmc/articles/PMC7407029/ /pubmed/32774664 http://dx.doi.org/10.1155/2020/1234059 Text en Copyright © 2020 Jing Guo et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Guo, Jing
Zheng, Hui Juan
Zhang, Wenting
Lou, Wenjiao
Xia, Chenhui
Han, Xue Ting
Huang, Wei Jun
Zhang, Fan
Wang, Yaoxian
Liu, Wei Jing
Accelerated Kidney Aging in Diabetes Mellitus
title Accelerated Kidney Aging in Diabetes Mellitus
title_full Accelerated Kidney Aging in Diabetes Mellitus
title_fullStr Accelerated Kidney Aging in Diabetes Mellitus
title_full_unstemmed Accelerated Kidney Aging in Diabetes Mellitus
title_short Accelerated Kidney Aging in Diabetes Mellitus
title_sort accelerated kidney aging in diabetes mellitus
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7407029/
https://www.ncbi.nlm.nih.gov/pubmed/32774664
http://dx.doi.org/10.1155/2020/1234059
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