TRPV4 Inhibition and CRISPR-Cas9 Knockout Reduce Inflammation Induced by Hyperphysiological Stretching in Human Annulus Fibrosus Cells

Mechanical loading and inflammation interact to cause degenerative disc disease and low back pain (LBP). However, the underlying mechanosensing and mechanotransductive pathways are poorly understood. This results in untargeted pharmacological treatments that do not take the mechanical aspect of LBP...

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Detalles Bibliográficos
Autores principales: Cambria, Elena, Arlt, Matthias J. E., Wandel, Sandra, Krupkova, Olga, Hitzl, Wolfgang, Passini, Fabian S., Hausmann, Oliver N., Snedeker, Jess G., Ferguson, Stephen J., Wuertz-Kozak, Karin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7407144/
https://www.ncbi.nlm.nih.gov/pubmed/32708074
http://dx.doi.org/10.3390/cells9071736

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