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Interpolymer Complexes of Eudragit(®) Copolymers as Novel Carriers for Colon-Specific Drug Delivery

Interpolymer complexes (IPC) based on Eudragit(®) EPO and Eudragit(®) S100 were investigated as potential carriers for oral controlled drug delivery to the colon. IPC samples were prepared by mixing copolymer solutions in organic solvents (ethanol, isopropanol:acetone mixture (60:40, % v/v) and tetr...

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Autores principales: Bukhovets, Aleksandra V., Fotaki, Nikoletta, Khutoryanskiy, Vitaliy V., Moustafine, Rouslan I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7407155/
https://www.ncbi.nlm.nih.gov/pubmed/32629765
http://dx.doi.org/10.3390/polym12071459
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author Bukhovets, Aleksandra V.
Fotaki, Nikoletta
Khutoryanskiy, Vitaliy V.
Moustafine, Rouslan I.
author_facet Bukhovets, Aleksandra V.
Fotaki, Nikoletta
Khutoryanskiy, Vitaliy V.
Moustafine, Rouslan I.
author_sort Bukhovets, Aleksandra V.
collection PubMed
description Interpolymer complexes (IPC) based on Eudragit(®) EPO and Eudragit(®) S100 were investigated as potential carriers for oral controlled drug delivery to the colon. IPC samples were prepared by mixing copolymer solutions in organic solvents (ethanol, isopropanol:acetone mixture (60:40, % v/v) and tetrahydrofuran). According to the data of elemental analysis, FTIR-spectroscopy, X-ray photoelectron spectroscopy and thermal analysis these IPCs have excess of anionic copolymer (Eudragit(®) S100) in their structure; they are stabilized by hydrogen and ionic intermacromolecular bonds and do not include free copolymer domains. IPC have pH-independent swelling properties in the media mimicking gastrointestinal tract (GIT) conditions and provide colon-specific delivery of indomethacin in buffer solutions (pH 1.2; 5.8; 6.8; 7.4) and in biorelevant media (fasted state simulated gastric fluid, fasted state simulated intestinal fluid—version 2 and fasted stated simulated colonic fluid).
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spelling pubmed-74071552020-08-11 Interpolymer Complexes of Eudragit(®) Copolymers as Novel Carriers for Colon-Specific Drug Delivery Bukhovets, Aleksandra V. Fotaki, Nikoletta Khutoryanskiy, Vitaliy V. Moustafine, Rouslan I. Polymers (Basel) Article Interpolymer complexes (IPC) based on Eudragit(®) EPO and Eudragit(®) S100 were investigated as potential carriers for oral controlled drug delivery to the colon. IPC samples were prepared by mixing copolymer solutions in organic solvents (ethanol, isopropanol:acetone mixture (60:40, % v/v) and tetrahydrofuran). According to the data of elemental analysis, FTIR-spectroscopy, X-ray photoelectron spectroscopy and thermal analysis these IPCs have excess of anionic copolymer (Eudragit(®) S100) in their structure; they are stabilized by hydrogen and ionic intermacromolecular bonds and do not include free copolymer domains. IPC have pH-independent swelling properties in the media mimicking gastrointestinal tract (GIT) conditions and provide colon-specific delivery of indomethacin in buffer solutions (pH 1.2; 5.8; 6.8; 7.4) and in biorelevant media (fasted state simulated gastric fluid, fasted state simulated intestinal fluid—version 2 and fasted stated simulated colonic fluid). MDPI 2020-06-30 /pmc/articles/PMC7407155/ /pubmed/32629765 http://dx.doi.org/10.3390/polym12071459 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Bukhovets, Aleksandra V.
Fotaki, Nikoletta
Khutoryanskiy, Vitaliy V.
Moustafine, Rouslan I.
Interpolymer Complexes of Eudragit(®) Copolymers as Novel Carriers for Colon-Specific Drug Delivery
title Interpolymer Complexes of Eudragit(®) Copolymers as Novel Carriers for Colon-Specific Drug Delivery
title_full Interpolymer Complexes of Eudragit(®) Copolymers as Novel Carriers for Colon-Specific Drug Delivery
title_fullStr Interpolymer Complexes of Eudragit(®) Copolymers as Novel Carriers for Colon-Specific Drug Delivery
title_full_unstemmed Interpolymer Complexes of Eudragit(®) Copolymers as Novel Carriers for Colon-Specific Drug Delivery
title_short Interpolymer Complexes of Eudragit(®) Copolymers as Novel Carriers for Colon-Specific Drug Delivery
title_sort interpolymer complexes of eudragit(®) copolymers as novel carriers for colon-specific drug delivery
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7407155/
https://www.ncbi.nlm.nih.gov/pubmed/32629765
http://dx.doi.org/10.3390/polym12071459
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