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Interpolymer Complexes of Eudragit(®) Copolymers as Novel Carriers for Colon-Specific Drug Delivery
Interpolymer complexes (IPC) based on Eudragit(®) EPO and Eudragit(®) S100 were investigated as potential carriers for oral controlled drug delivery to the colon. IPC samples were prepared by mixing copolymer solutions in organic solvents (ethanol, isopropanol:acetone mixture (60:40, % v/v) and tetr...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7407155/ https://www.ncbi.nlm.nih.gov/pubmed/32629765 http://dx.doi.org/10.3390/polym12071459 |
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author | Bukhovets, Aleksandra V. Fotaki, Nikoletta Khutoryanskiy, Vitaliy V. Moustafine, Rouslan I. |
author_facet | Bukhovets, Aleksandra V. Fotaki, Nikoletta Khutoryanskiy, Vitaliy V. Moustafine, Rouslan I. |
author_sort | Bukhovets, Aleksandra V. |
collection | PubMed |
description | Interpolymer complexes (IPC) based on Eudragit(®) EPO and Eudragit(®) S100 were investigated as potential carriers for oral controlled drug delivery to the colon. IPC samples were prepared by mixing copolymer solutions in organic solvents (ethanol, isopropanol:acetone mixture (60:40, % v/v) and tetrahydrofuran). According to the data of elemental analysis, FTIR-spectroscopy, X-ray photoelectron spectroscopy and thermal analysis these IPCs have excess of anionic copolymer (Eudragit(®) S100) in their structure; they are stabilized by hydrogen and ionic intermacromolecular bonds and do not include free copolymer domains. IPC have pH-independent swelling properties in the media mimicking gastrointestinal tract (GIT) conditions and provide colon-specific delivery of indomethacin in buffer solutions (pH 1.2; 5.8; 6.8; 7.4) and in biorelevant media (fasted state simulated gastric fluid, fasted state simulated intestinal fluid—version 2 and fasted stated simulated colonic fluid). |
format | Online Article Text |
id | pubmed-7407155 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-74071552020-08-11 Interpolymer Complexes of Eudragit(®) Copolymers as Novel Carriers for Colon-Specific Drug Delivery Bukhovets, Aleksandra V. Fotaki, Nikoletta Khutoryanskiy, Vitaliy V. Moustafine, Rouslan I. Polymers (Basel) Article Interpolymer complexes (IPC) based on Eudragit(®) EPO and Eudragit(®) S100 were investigated as potential carriers for oral controlled drug delivery to the colon. IPC samples were prepared by mixing copolymer solutions in organic solvents (ethanol, isopropanol:acetone mixture (60:40, % v/v) and tetrahydrofuran). According to the data of elemental analysis, FTIR-spectroscopy, X-ray photoelectron spectroscopy and thermal analysis these IPCs have excess of anionic copolymer (Eudragit(®) S100) in their structure; they are stabilized by hydrogen and ionic intermacromolecular bonds and do not include free copolymer domains. IPC have pH-independent swelling properties in the media mimicking gastrointestinal tract (GIT) conditions and provide colon-specific delivery of indomethacin in buffer solutions (pH 1.2; 5.8; 6.8; 7.4) and in biorelevant media (fasted state simulated gastric fluid, fasted state simulated intestinal fluid—version 2 and fasted stated simulated colonic fluid). MDPI 2020-06-30 /pmc/articles/PMC7407155/ /pubmed/32629765 http://dx.doi.org/10.3390/polym12071459 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Bukhovets, Aleksandra V. Fotaki, Nikoletta Khutoryanskiy, Vitaliy V. Moustafine, Rouslan I. Interpolymer Complexes of Eudragit(®) Copolymers as Novel Carriers for Colon-Specific Drug Delivery |
title | Interpolymer Complexes of Eudragit(®) Copolymers as Novel Carriers for Colon-Specific Drug Delivery |
title_full | Interpolymer Complexes of Eudragit(®) Copolymers as Novel Carriers for Colon-Specific Drug Delivery |
title_fullStr | Interpolymer Complexes of Eudragit(®) Copolymers as Novel Carriers for Colon-Specific Drug Delivery |
title_full_unstemmed | Interpolymer Complexes of Eudragit(®) Copolymers as Novel Carriers for Colon-Specific Drug Delivery |
title_short | Interpolymer Complexes of Eudragit(®) Copolymers as Novel Carriers for Colon-Specific Drug Delivery |
title_sort | interpolymer complexes of eudragit(®) copolymers as novel carriers for colon-specific drug delivery |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7407155/ https://www.ncbi.nlm.nih.gov/pubmed/32629765 http://dx.doi.org/10.3390/polym12071459 |
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