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Autophagy Roles in Genome Maintenance

In recent years, a considerable correlation has emerged between autophagy and genome integrity. A range of mechanisms appear to be involved where autophagy participates in preventing genomic instability, as well as in DNA damage response and cell fate decision. These initial findings have attracted...

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Detalles Bibliográficos
Autores principales: Ambrosio, Susanna, Majello, Barbara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7407194/
https://www.ncbi.nlm.nih.gov/pubmed/32635505
http://dx.doi.org/10.3390/cancers12071793
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author Ambrosio, Susanna
Majello, Barbara
author_facet Ambrosio, Susanna
Majello, Barbara
author_sort Ambrosio, Susanna
collection PubMed
description In recent years, a considerable correlation has emerged between autophagy and genome integrity. A range of mechanisms appear to be involved where autophagy participates in preventing genomic instability, as well as in DNA damage response and cell fate decision. These initial findings have attracted particular attention in the context of malignancy; however, the crosstalk between autophagy and DNA damage response is just beginning to be explored and key questions remain that need to be addressed, to move this area of research forward and illuminate the overall consequence of targeting this process in human therapies. Here we present current knowledge on the complex crosstalk between autophagy and genome integrity and discuss its implications for cancer cell survival and response to therapy.
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spelling pubmed-74071942020-08-11 Autophagy Roles in Genome Maintenance Ambrosio, Susanna Majello, Barbara Cancers (Basel) Review In recent years, a considerable correlation has emerged between autophagy and genome integrity. A range of mechanisms appear to be involved where autophagy participates in preventing genomic instability, as well as in DNA damage response and cell fate decision. These initial findings have attracted particular attention in the context of malignancy; however, the crosstalk between autophagy and DNA damage response is just beginning to be explored and key questions remain that need to be addressed, to move this area of research forward and illuminate the overall consequence of targeting this process in human therapies. Here we present current knowledge on the complex crosstalk between autophagy and genome integrity and discuss its implications for cancer cell survival and response to therapy. MDPI 2020-07-04 /pmc/articles/PMC7407194/ /pubmed/32635505 http://dx.doi.org/10.3390/cancers12071793 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Ambrosio, Susanna
Majello, Barbara
Autophagy Roles in Genome Maintenance
title Autophagy Roles in Genome Maintenance
title_full Autophagy Roles in Genome Maintenance
title_fullStr Autophagy Roles in Genome Maintenance
title_full_unstemmed Autophagy Roles in Genome Maintenance
title_short Autophagy Roles in Genome Maintenance
title_sort autophagy roles in genome maintenance
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7407194/
https://www.ncbi.nlm.nih.gov/pubmed/32635505
http://dx.doi.org/10.3390/cancers12071793
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