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Autophagy Roles in Genome Maintenance
In recent years, a considerable correlation has emerged between autophagy and genome integrity. A range of mechanisms appear to be involved where autophagy participates in preventing genomic instability, as well as in DNA damage response and cell fate decision. These initial findings have attracted...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7407194/ https://www.ncbi.nlm.nih.gov/pubmed/32635505 http://dx.doi.org/10.3390/cancers12071793 |
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author | Ambrosio, Susanna Majello, Barbara |
author_facet | Ambrosio, Susanna Majello, Barbara |
author_sort | Ambrosio, Susanna |
collection | PubMed |
description | In recent years, a considerable correlation has emerged between autophagy and genome integrity. A range of mechanisms appear to be involved where autophagy participates in preventing genomic instability, as well as in DNA damage response and cell fate decision. These initial findings have attracted particular attention in the context of malignancy; however, the crosstalk between autophagy and DNA damage response is just beginning to be explored and key questions remain that need to be addressed, to move this area of research forward and illuminate the overall consequence of targeting this process in human therapies. Here we present current knowledge on the complex crosstalk between autophagy and genome integrity and discuss its implications for cancer cell survival and response to therapy. |
format | Online Article Text |
id | pubmed-7407194 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-74071942020-08-11 Autophagy Roles in Genome Maintenance Ambrosio, Susanna Majello, Barbara Cancers (Basel) Review In recent years, a considerable correlation has emerged between autophagy and genome integrity. A range of mechanisms appear to be involved where autophagy participates in preventing genomic instability, as well as in DNA damage response and cell fate decision. These initial findings have attracted particular attention in the context of malignancy; however, the crosstalk between autophagy and DNA damage response is just beginning to be explored and key questions remain that need to be addressed, to move this area of research forward and illuminate the overall consequence of targeting this process in human therapies. Here we present current knowledge on the complex crosstalk between autophagy and genome integrity and discuss its implications for cancer cell survival and response to therapy. MDPI 2020-07-04 /pmc/articles/PMC7407194/ /pubmed/32635505 http://dx.doi.org/10.3390/cancers12071793 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Ambrosio, Susanna Majello, Barbara Autophagy Roles in Genome Maintenance |
title | Autophagy Roles in Genome Maintenance |
title_full | Autophagy Roles in Genome Maintenance |
title_fullStr | Autophagy Roles in Genome Maintenance |
title_full_unstemmed | Autophagy Roles in Genome Maintenance |
title_short | Autophagy Roles in Genome Maintenance |
title_sort | autophagy roles in genome maintenance |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7407194/ https://www.ncbi.nlm.nih.gov/pubmed/32635505 http://dx.doi.org/10.3390/cancers12071793 |
work_keys_str_mv | AT ambrosiosusanna autophagyrolesingenomemaintenance AT majellobarbara autophagyrolesingenomemaintenance |