Merkel Cell Polyomavirus and Merkel Cell Carcinoma

Viruses are the cause of approximately 15% of all human cancers. Both RNA and DNA human tumor viruses have been identified, with Merkel cell polyomavirus being the most recent one to be linked to cancer. This virus is associated with about 80% of Merkel cell carcinomas, a rare, but aggressive cutane...

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Detalles Bibliográficos
Autores principales: Pietropaolo, Valeria, Prezioso, Carla, Moens, Ugo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7407210/
https://www.ncbi.nlm.nih.gov/pubmed/32635198
http://dx.doi.org/10.3390/cancers12071774
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author Pietropaolo, Valeria
Prezioso, Carla
Moens, Ugo
author_facet Pietropaolo, Valeria
Prezioso, Carla
Moens, Ugo
author_sort Pietropaolo, Valeria
collection PubMed
description Viruses are the cause of approximately 15% of all human cancers. Both RNA and DNA human tumor viruses have been identified, with Merkel cell polyomavirus being the most recent one to be linked to cancer. This virus is associated with about 80% of Merkel cell carcinomas, a rare, but aggressive cutaneous malignancy. Despite its name, the cells of origin of this tumor may not be Merkel cells. This review provides an update on the structure and life cycle, cell tropism and epidemiology of the virus and its oncogenic properties. Putative strategies to prevent viral infection or treat virus-positive Merkel cell carcinoma patients are discussed.
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spelling pubmed-74072102020-08-11 Merkel Cell Polyomavirus and Merkel Cell Carcinoma Pietropaolo, Valeria Prezioso, Carla Moens, Ugo Cancers (Basel) Review Viruses are the cause of approximately 15% of all human cancers. Both RNA and DNA human tumor viruses have been identified, with Merkel cell polyomavirus being the most recent one to be linked to cancer. This virus is associated with about 80% of Merkel cell carcinomas, a rare, but aggressive cutaneous malignancy. Despite its name, the cells of origin of this tumor may not be Merkel cells. This review provides an update on the structure and life cycle, cell tropism and epidemiology of the virus and its oncogenic properties. Putative strategies to prevent viral infection or treat virus-positive Merkel cell carcinoma patients are discussed. MDPI 2020-07-03 /pmc/articles/PMC7407210/ /pubmed/32635198 http://dx.doi.org/10.3390/cancers12071774 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Pietropaolo, Valeria
Prezioso, Carla
Moens, Ugo
Merkel Cell Polyomavirus and Merkel Cell Carcinoma
title Merkel Cell Polyomavirus and Merkel Cell Carcinoma
title_full Merkel Cell Polyomavirus and Merkel Cell Carcinoma
title_fullStr Merkel Cell Polyomavirus and Merkel Cell Carcinoma
title_full_unstemmed Merkel Cell Polyomavirus and Merkel Cell Carcinoma
title_short Merkel Cell Polyomavirus and Merkel Cell Carcinoma
title_sort merkel cell polyomavirus and merkel cell carcinoma
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7407210/
https://www.ncbi.nlm.nih.gov/pubmed/32635198
http://dx.doi.org/10.3390/cancers12071774
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