Cargando…
Deamidated Human Triosephosphate Isomerase is a Promising Druggable Target
Therapeutic strategies for the treatment of any severe disease are based on the discovery and validation of druggable targets. The human genome encodes only 600–1500 targets for small-molecule drugs, but posttranslational modifications lead to a considerably larger druggable proteome. The spontaneou...
Autores principales: | Enríquez-Flores, Sergio, Flores-López, Luis Antonio, García-Torres, Itzhel, de la Mora-de la Mora, Ignacio, Cabrera, Nallely, Gutiérrez-Castrellón, Pedro, Martínez-Pérez, Yoalli, López-Velázquez, Gabriel |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7407242/ https://www.ncbi.nlm.nih.gov/pubmed/32679775 http://dx.doi.org/10.3390/biom10071050 |
Ejemplares similares
-
Naturally occurring deamidated triosephosphate isomerase is a promising target for cell-selective therapy in cancer
por: Enríquez-Flores, Sergio, et al.
Publicado: (2022) -
Human Triosephosphate Isomerase Is a Potential Target in Cancer Due to Commonly Occurring Post-Translational Modifications
por: Enríquez-Flores, Sergio, et al.
Publicado: (2023) -
Structural Effects of Protein Aging: Terminal Marking by Deamidation in Human Triosephosphate Isomerase
por: de la Mora-de la Mora, Ignacio, et al.
Publicado: (2015) -
Repurposing of rabeprazole as an anti-Trypanosoma cruzi drug that targets cellular triosephosphate isomerase
por: García-Torres, Itzhel, et al.
Publicado: (2023) -
First characterization of a microsporidial triosephosphate isomerase and the biochemical mechanisms of its inactivation to propose a new druggable target
por: García-Torres, Itzhel, et al.
Publicado: (2018)