Cargando…

Induction of Lysosome Membrane Permeabilization as a Therapeutic Strategy to Target Pancreatic Cancer Stem Cells

Despite significant efforts to improve pancreatic ductal adenocarcinoma (PDAC) clinical outcomes, overall survival remains dismal. The poor response to current therapies is partly due to the existence of pancreatic cancer stem cells (PaCSCs), which are efficient drivers of PDAC tumorigenesis, metast...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cash, Timothy P., Alcalá, Sonia, Rico-Ferreira, María del Rosario, Hernández-Encinas, Elena, García, Jennifer, Albarrán, María Isabel, Valle, Sandra, Muñoz, Javier, Martínez-González, Sonia, Blanco-Aparicio, Carmen, Pastor, Joaquín, Serrano, Manuel, Sainz, Bruno
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7407272/ https://www.ncbi.nlm.nih.gov/pubmed/32635473 http://dx.doi.org/10.3390/cancers12071790

Ejemplares similares

Regulation of apoptosis-associated lysosomal membrane permeabilization
por: Johansson, Ann-Charlotte, et al.
Publicado: (2010)

Contribution of Particle-Induced Lysosomal Membrane Hyperpolarization to Lysosomal Membrane Permeabilization
por: Ziglari, Tahereh, et al.
Publicado: (2021)

Marine alkaloid Monanchocidin a overcomes drug resistance by induction of autophagy and lysosomal membrane permeabilization
por: Dyshlovoy, Sergey A., et al.
Publicado: (2015)

Coupling of lysosomal and mitochondrial membrane permeabilization in trypanolysis by APOL1
por: Vanwalleghem, Gilles, et al.
Publicado: (2015)

Lysosomal trapping of palbociclib and its functional implications
por: Llanos, Susana, et al.
Publicado: (2019)

Natural Products Induce Lysosomal Membrane Permeabilization as an Anticancer Strategy
por: Halaby, Reginald
Publicado: (2021)

Pterostilbene-Induced Tumor Cytotoxicity: A Lysosomal Membrane Permeabilization-Dependent Mechanism
por: Mena, Salvador, et al.
Publicado: (2012)

MUC1c Regulates Cell Survival in Pancreatic Cancer by Preventing Lysosomal Permeabilization
por: Banerjee, Sulagna, et al.
Publicado: (2012)

Effect of glutamate on lysosomal membrane permeabilization in primary cultured cortical neurons
por: YAN, MIN, et al.
Publicado: (2016)

Synthesis of an Hsp70 inhibitor and its assessment of lysosomal membrane permeabilization
por: Park, Sang-Hyun, et al.
Publicado: (2021)

Real-Time Monitoring of Lysosomal Membrane Permeabilization Using Acridine Orange
por: Eriksson, Ida, et al.
Publicado: (2023)

A self-assembled nanophotosensitizer targets lysosomes and induces lysosomal membrane permeabilization to enhance photodynamic therapy
por: Li, Youyou, et al.
Publicado: (2023)

Heat Shock Protein 70 Promotes Cell Survival by Inhibiting Lysosomal Membrane Permeabilization
por: Nylandsted, Jesper, et al.
Publicado: (2004)

The acidic transformed nano-VO(2) causes macrophage cell death by the induction of lysosomal membrane permeabilization and Ca(2+) efflux
por: Xu, Shaohai, et al.
Publicado: (2015)

Lysosomal Membrane Permeabilization Induces Cell Death in a Mitochondrion-dependent Fashion
por: Boya, Patricia, et al.
Publicado: (2003)

Increased Lysosomal Membrane Permeabilization in Oxidant-exposed Macrophages of Human Fibrotic Lungs
por: Persson, Hans L, et al.
Publicado: (2013)

PIG7 promotes leukemia cell chemosensitivity via lysosomal membrane permeabilization
por: Liu, Jiazhuo, et al.
Publicado: (2015)

Changes of lysosomal membrane permeabilization and lipid metabolism in sidt2 deficient mice
por: Meng, Yu, et al.
Publicado: (2018)

Galactosyl- and glucosylsphingosine induce lysosomal membrane permeabilization and cell death in cancer cells
por: Stahl-Meyer, Kamilla, et al.
Publicado: (2022)

Induction of Lysosomal Membrane Permeabilization Is a Major Event of FTY720-Mediated Non-Apoptotic Cell Death in Human Glioma Cells
por: Min, Kyoung-jin, et al.
Publicado: (2020)

(-)-Oleocanthal rapidly and selectively induces cancer cell death via lysosomal membrane permeabilization
por: LeGendre, Onica, et al.
Publicado: (2015)

(-)-Oleocanthal and (-)-oleocanthal-rich olive oils induce lysosomal membrane permeabilization in cancer cells
por: Goren, Limor, et al.
Publicado: (2019)

Lysosomal Membrane Permeabilization is an Early Event in Sigma-2 Receptor Ligand Mediated Cell Death in Pancreatic Cancer
por: Hornick, John R, et al.
Publicado: (2012)

Inhibition of Sp1 prevents ER homeostasis and causes cell death by lysosomal membrane permeabilization in pancreatic cancer
por: Dauer, Patricia, et al.
Publicado: (2017)

The Ever-Evolving Concept of the Cancer Stem Cell in Pancreatic Cancer
por: Valle, Sandra, et al.
Publicado: (2018)

DRAM Triggers Lysosomal Membrane Permeabilization and Cell Death in CD4(+) T Cells Infected with HIV
por: Laforge, Mireille, et al.
Publicado: (2013)

The Octyl Ester of Ginsenoside Rh2 Induces Lysosomal Membrane Permeabilization via Bax Translocation
por: Chen, Fang, et al.
Publicado: (2016)

Suppressing UVRAG Induces Radiosensitivity by Triggering Lysosomal Membrane Permeabilization in Hypopharyngeal Squamous Cell Carcinoma
por: Wang, Jianwen, et al.
Publicado: (2020)

Disulfiram, a Ferroptosis Inducer, Triggers Lysosomal Membrane Permeabilization by Up-Regulating ROS in Glioblastoma
por: Qiu, Chen, et al.
Publicado: (2020)

Oxidative stress induces lysosomal membrane permeabilization and ceramide accumulation in retinal pigment epithelial cells
por: Zhang, Kevin R., et al.
Publicado: (2023)

Targeting MAD2 modulates stemness and tumorigenesis in human Gastric Cancer cell lines
por: Pajuelo-Lozano, Natalia, et al.
Publicado: (2020)

Acetate-induced apoptosis in colorectal carcinoma cells involves lysosomal membrane permeabilization and cathepsin D release
por: Marques, C, et al.
Publicado: (2013)

ROS-mediated lysosomal membrane permeabilization is involved in bupivacaine-induced death of rabbit intervertebral disc cells
por: Cai, Xianyi, et al.
Publicado: (2018)

Lysosomal membrane permeabilization causes secretion of IL-1β in human vascular smooth muscle cells
por: Ono, Hiroaki, et al.
Publicado: (2018)

Triarylpyridine Compounds and Chloroquine Act in Concert to Trigger Lysosomal Membrane Permeabilization and Cell Death in Cancer Cells
por: Beauvarlet, Jennifer, et al.
Publicado: (2020)

Macrolide antibiotics enhance the antitumor effect of lansoprazole resulting in lysosomal membrane permeabilization-associated cell death
por: Takeda, Atsuo, et al.
Publicado: (2020)

Progressive lysosomal membrane permeabilization induced by iron oxide nanoparticles drives hepatic cell autophagy and apoptosis
por: Levada, Kateryna, et al.
Publicado: (2020)

Azithromycin enhances the cytotoxicity of DNA‐damaging drugs via lysosomal membrane permeabilization in lung cancer cells
por: Toriyama, Kazutoshi, et al.
Publicado: (2021)

Low‐level lysosomal membrane permeabilization for limited release and sublethal functions of cathepsin proteases in the cytosol and nucleus
por: Reinheckel, Thomas, et al.
Publicado: (2022)

p53 regulates lysosomal membrane permeabilization as well as cytoprotective autophagy in response to DNA-damaging drugs
por: Yamashita, Gai, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_rbg1ildu0shtf95h1ee10o4gj5