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Basics and Frontiers on Pancreatic Cancer for Radiation Oncology: Target Delineation, SBRT, SIB Technique, MRgRT, Particle Therapy, Immunotherapy and Clinical Guidelines
Pancreatic cancer represents a modern oncological urgency. Its management is aimed to both distal and local disease control. Resectability is the cornerstone of treatment aim. It influences the clinical presentation’s definitions as up-front resectable, borderline resectable and locally advanced (un...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7407382/ https://www.ncbi.nlm.nih.gov/pubmed/32610592 http://dx.doi.org/10.3390/cancers12071729 |
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author | Cellini, Francesco Arcelli, Alessandra Simoni, Nicola Caravatta, Luciana Buwenge, Milly Calabrese, Angela Brunetti, Oronzo Genovesi, Domenico Mazzarotto, Renzo Deodato, Francesco Mattiucci, Gian Carlo Silvestris, Nicola Valentini, Vincenzo Morganti, Alessio Giuseppe |
author_facet | Cellini, Francesco Arcelli, Alessandra Simoni, Nicola Caravatta, Luciana Buwenge, Milly Calabrese, Angela Brunetti, Oronzo Genovesi, Domenico Mazzarotto, Renzo Deodato, Francesco Mattiucci, Gian Carlo Silvestris, Nicola Valentini, Vincenzo Morganti, Alessio Giuseppe |
author_sort | Cellini, Francesco |
collection | PubMed |
description | Pancreatic cancer represents a modern oncological urgency. Its management is aimed to both distal and local disease control. Resectability is the cornerstone of treatment aim. It influences the clinical presentation’s definitions as up-front resectable, borderline resectable and locally advanced (unresectable). The main treatment categories are neoadjuvant (preoperative), definitive and adjuvant (postoperative). This review will focus on (i) the current indications by the available national and international guidelines; (ii) the current standard indications for target volume delineation in radiotherapy (RT); (iii) the emerging modern technologies (including particle therapy and Magnetic Resonance [MR]-guided-RT); (iv) stereotactic body radiotherapy (SBRT), as the most promising technical delivery application of RT in this framework; (v) a particularly promising dose delivery technique called simultaneous integrated boost (SIB); and (vi) a multimodal integration opportunity: the combination of RT with immunotherapy. |
format | Online Article Text |
id | pubmed-7407382 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-74073822020-08-25 Basics and Frontiers on Pancreatic Cancer for Radiation Oncology: Target Delineation, SBRT, SIB Technique, MRgRT, Particle Therapy, Immunotherapy and Clinical Guidelines Cellini, Francesco Arcelli, Alessandra Simoni, Nicola Caravatta, Luciana Buwenge, Milly Calabrese, Angela Brunetti, Oronzo Genovesi, Domenico Mazzarotto, Renzo Deodato, Francesco Mattiucci, Gian Carlo Silvestris, Nicola Valentini, Vincenzo Morganti, Alessio Giuseppe Cancers (Basel) Review Pancreatic cancer represents a modern oncological urgency. Its management is aimed to both distal and local disease control. Resectability is the cornerstone of treatment aim. It influences the clinical presentation’s definitions as up-front resectable, borderline resectable and locally advanced (unresectable). The main treatment categories are neoadjuvant (preoperative), definitive and adjuvant (postoperative). This review will focus on (i) the current indications by the available national and international guidelines; (ii) the current standard indications for target volume delineation in radiotherapy (RT); (iii) the emerging modern technologies (including particle therapy and Magnetic Resonance [MR]-guided-RT); (iv) stereotactic body radiotherapy (SBRT), as the most promising technical delivery application of RT in this framework; (v) a particularly promising dose delivery technique called simultaneous integrated boost (SIB); and (vi) a multimodal integration opportunity: the combination of RT with immunotherapy. MDPI 2020-06-29 /pmc/articles/PMC7407382/ /pubmed/32610592 http://dx.doi.org/10.3390/cancers12071729 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Cellini, Francesco Arcelli, Alessandra Simoni, Nicola Caravatta, Luciana Buwenge, Milly Calabrese, Angela Brunetti, Oronzo Genovesi, Domenico Mazzarotto, Renzo Deodato, Francesco Mattiucci, Gian Carlo Silvestris, Nicola Valentini, Vincenzo Morganti, Alessio Giuseppe Basics and Frontiers on Pancreatic Cancer for Radiation Oncology: Target Delineation, SBRT, SIB Technique, MRgRT, Particle Therapy, Immunotherapy and Clinical Guidelines |
title | Basics and Frontiers on Pancreatic Cancer for Radiation Oncology: Target Delineation, SBRT, SIB Technique, MRgRT, Particle Therapy, Immunotherapy and Clinical Guidelines |
title_full | Basics and Frontiers on Pancreatic Cancer for Radiation Oncology: Target Delineation, SBRT, SIB Technique, MRgRT, Particle Therapy, Immunotherapy and Clinical Guidelines |
title_fullStr | Basics and Frontiers on Pancreatic Cancer for Radiation Oncology: Target Delineation, SBRT, SIB Technique, MRgRT, Particle Therapy, Immunotherapy and Clinical Guidelines |
title_full_unstemmed | Basics and Frontiers on Pancreatic Cancer for Radiation Oncology: Target Delineation, SBRT, SIB Technique, MRgRT, Particle Therapy, Immunotherapy and Clinical Guidelines |
title_short | Basics and Frontiers on Pancreatic Cancer for Radiation Oncology: Target Delineation, SBRT, SIB Technique, MRgRT, Particle Therapy, Immunotherapy and Clinical Guidelines |
title_sort | basics and frontiers on pancreatic cancer for radiation oncology: target delineation, sbrt, sib technique, mrgrt, particle therapy, immunotherapy and clinical guidelines |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7407382/ https://www.ncbi.nlm.nih.gov/pubmed/32610592 http://dx.doi.org/10.3390/cancers12071729 |
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