Cargando…

Basics and Frontiers on Pancreatic Cancer for Radiation Oncology: Target Delineation, SBRT, SIB Technique, MRgRT, Particle Therapy, Immunotherapy and Clinical Guidelines

Pancreatic cancer represents a modern oncological urgency. Its management is aimed to both distal and local disease control. Resectability is the cornerstone of treatment aim. It influences the clinical presentation’s definitions as up-front resectable, borderline resectable and locally advanced (un...

Descripción completa

Detalles Bibliográficos
Autores principales: Cellini, Francesco, Arcelli, Alessandra, Simoni, Nicola, Caravatta, Luciana, Buwenge, Milly, Calabrese, Angela, Brunetti, Oronzo, Genovesi, Domenico, Mazzarotto, Renzo, Deodato, Francesco, Mattiucci, Gian Carlo, Silvestris, Nicola, Valentini, Vincenzo, Morganti, Alessio Giuseppe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7407382/
https://www.ncbi.nlm.nih.gov/pubmed/32610592
http://dx.doi.org/10.3390/cancers12071729
_version_ 1783567607653203968
author Cellini, Francesco
Arcelli, Alessandra
Simoni, Nicola
Caravatta, Luciana
Buwenge, Milly
Calabrese, Angela
Brunetti, Oronzo
Genovesi, Domenico
Mazzarotto, Renzo
Deodato, Francesco
Mattiucci, Gian Carlo
Silvestris, Nicola
Valentini, Vincenzo
Morganti, Alessio Giuseppe
author_facet Cellini, Francesco
Arcelli, Alessandra
Simoni, Nicola
Caravatta, Luciana
Buwenge, Milly
Calabrese, Angela
Brunetti, Oronzo
Genovesi, Domenico
Mazzarotto, Renzo
Deodato, Francesco
Mattiucci, Gian Carlo
Silvestris, Nicola
Valentini, Vincenzo
Morganti, Alessio Giuseppe
author_sort Cellini, Francesco
collection PubMed
description Pancreatic cancer represents a modern oncological urgency. Its management is aimed to both distal and local disease control. Resectability is the cornerstone of treatment aim. It influences the clinical presentation’s definitions as up-front resectable, borderline resectable and locally advanced (unresectable). The main treatment categories are neoadjuvant (preoperative), definitive and adjuvant (postoperative). This review will focus on (i) the current indications by the available national and international guidelines; (ii) the current standard indications for target volume delineation in radiotherapy (RT); (iii) the emerging modern technologies (including particle therapy and Magnetic Resonance [MR]-guided-RT); (iv) stereotactic body radiotherapy (SBRT), as the most promising technical delivery application of RT in this framework; (v) a particularly promising dose delivery technique called simultaneous integrated boost (SIB); and (vi) a multimodal integration opportunity: the combination of RT with immunotherapy.
format Online
Article
Text
id pubmed-7407382
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-74073822020-08-25 Basics and Frontiers on Pancreatic Cancer for Radiation Oncology: Target Delineation, SBRT, SIB Technique, MRgRT, Particle Therapy, Immunotherapy and Clinical Guidelines Cellini, Francesco Arcelli, Alessandra Simoni, Nicola Caravatta, Luciana Buwenge, Milly Calabrese, Angela Brunetti, Oronzo Genovesi, Domenico Mazzarotto, Renzo Deodato, Francesco Mattiucci, Gian Carlo Silvestris, Nicola Valentini, Vincenzo Morganti, Alessio Giuseppe Cancers (Basel) Review Pancreatic cancer represents a modern oncological urgency. Its management is aimed to both distal and local disease control. Resectability is the cornerstone of treatment aim. It influences the clinical presentation’s definitions as up-front resectable, borderline resectable and locally advanced (unresectable). The main treatment categories are neoadjuvant (preoperative), definitive and adjuvant (postoperative). This review will focus on (i) the current indications by the available national and international guidelines; (ii) the current standard indications for target volume delineation in radiotherapy (RT); (iii) the emerging modern technologies (including particle therapy and Magnetic Resonance [MR]-guided-RT); (iv) stereotactic body radiotherapy (SBRT), as the most promising technical delivery application of RT in this framework; (v) a particularly promising dose delivery technique called simultaneous integrated boost (SIB); and (vi) a multimodal integration opportunity: the combination of RT with immunotherapy. MDPI 2020-06-29 /pmc/articles/PMC7407382/ /pubmed/32610592 http://dx.doi.org/10.3390/cancers12071729 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Cellini, Francesco
Arcelli, Alessandra
Simoni, Nicola
Caravatta, Luciana
Buwenge, Milly
Calabrese, Angela
Brunetti, Oronzo
Genovesi, Domenico
Mazzarotto, Renzo
Deodato, Francesco
Mattiucci, Gian Carlo
Silvestris, Nicola
Valentini, Vincenzo
Morganti, Alessio Giuseppe
Basics and Frontiers on Pancreatic Cancer for Radiation Oncology: Target Delineation, SBRT, SIB Technique, MRgRT, Particle Therapy, Immunotherapy and Clinical Guidelines
title Basics and Frontiers on Pancreatic Cancer for Radiation Oncology: Target Delineation, SBRT, SIB Technique, MRgRT, Particle Therapy, Immunotherapy and Clinical Guidelines
title_full Basics and Frontiers on Pancreatic Cancer for Radiation Oncology: Target Delineation, SBRT, SIB Technique, MRgRT, Particle Therapy, Immunotherapy and Clinical Guidelines
title_fullStr Basics and Frontiers on Pancreatic Cancer for Radiation Oncology: Target Delineation, SBRT, SIB Technique, MRgRT, Particle Therapy, Immunotherapy and Clinical Guidelines
title_full_unstemmed Basics and Frontiers on Pancreatic Cancer for Radiation Oncology: Target Delineation, SBRT, SIB Technique, MRgRT, Particle Therapy, Immunotherapy and Clinical Guidelines
title_short Basics and Frontiers on Pancreatic Cancer for Radiation Oncology: Target Delineation, SBRT, SIB Technique, MRgRT, Particle Therapy, Immunotherapy and Clinical Guidelines
title_sort basics and frontiers on pancreatic cancer for radiation oncology: target delineation, sbrt, sib technique, mrgrt, particle therapy, immunotherapy and clinical guidelines
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7407382/
https://www.ncbi.nlm.nih.gov/pubmed/32610592
http://dx.doi.org/10.3390/cancers12071729
work_keys_str_mv AT cellinifrancesco basicsandfrontiersonpancreaticcancerforradiationoncologytargetdelineationsbrtsibtechniquemrgrtparticletherapyimmunotherapyandclinicalguidelines
AT arcellialessandra basicsandfrontiersonpancreaticcancerforradiationoncologytargetdelineationsbrtsibtechniquemrgrtparticletherapyimmunotherapyandclinicalguidelines
AT simoninicola basicsandfrontiersonpancreaticcancerforradiationoncologytargetdelineationsbrtsibtechniquemrgrtparticletherapyimmunotherapyandclinicalguidelines
AT caravattaluciana basicsandfrontiersonpancreaticcancerforradiationoncologytargetdelineationsbrtsibtechniquemrgrtparticletherapyimmunotherapyandclinicalguidelines
AT buwengemilly basicsandfrontiersonpancreaticcancerforradiationoncologytargetdelineationsbrtsibtechniquemrgrtparticletherapyimmunotherapyandclinicalguidelines
AT calabreseangela basicsandfrontiersonpancreaticcancerforradiationoncologytargetdelineationsbrtsibtechniquemrgrtparticletherapyimmunotherapyandclinicalguidelines
AT brunettioronzo basicsandfrontiersonpancreaticcancerforradiationoncologytargetdelineationsbrtsibtechniquemrgrtparticletherapyimmunotherapyandclinicalguidelines
AT genovesidomenico basicsandfrontiersonpancreaticcancerforradiationoncologytargetdelineationsbrtsibtechniquemrgrtparticletherapyimmunotherapyandclinicalguidelines
AT mazzarottorenzo basicsandfrontiersonpancreaticcancerforradiationoncologytargetdelineationsbrtsibtechniquemrgrtparticletherapyimmunotherapyandclinicalguidelines
AT deodatofrancesco basicsandfrontiersonpancreaticcancerforradiationoncologytargetdelineationsbrtsibtechniquemrgrtparticletherapyimmunotherapyandclinicalguidelines
AT mattiuccigiancarlo basicsandfrontiersonpancreaticcancerforradiationoncologytargetdelineationsbrtsibtechniquemrgrtparticletherapyimmunotherapyandclinicalguidelines
AT silvestrisnicola basicsandfrontiersonpancreaticcancerforradiationoncologytargetdelineationsbrtsibtechniquemrgrtparticletherapyimmunotherapyandclinicalguidelines
AT valentinivincenzo basicsandfrontiersonpancreaticcancerforradiationoncologytargetdelineationsbrtsibtechniquemrgrtparticletherapyimmunotherapyandclinicalguidelines
AT morgantialessiogiuseppe basicsandfrontiersonpancreaticcancerforradiationoncologytargetdelineationsbrtsibtechniquemrgrtparticletherapyimmunotherapyandclinicalguidelines