Cargando…

Potential Added Value of PET/CT Radiomics for Survival Prognostication beyond AJCC 8th Edition Staging in Oropharyngeal Squamous Cell Carcinoma

Accurate risk-stratification can facilitate precision therapy in oropharyngeal squamous cell carcinoma (OPSCC). We explored the potential added value of baseline positron emission tomography (PET)/computed tomography (CT) radiomic features for prognostication and risk stratification of OPSCC beyond...

Descripción completa

Detalles Bibliográficos
Autores principales: Haider, Stefan P., Zeevi, Tal, Baumeister, Philipp, Reichel, Christoph, Sharaf, Kariem, Forghani, Reza, Kann, Benjamin H., Judson, Benjamin L., Prasad, Manju L., Burtness, Barbara, Mahajan, Amit, Payabvash, Seyedmehdi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7407414/
https://www.ncbi.nlm.nih.gov/pubmed/32635216
http://dx.doi.org/10.3390/cancers12071778
_version_ 1783567615153668096
author Haider, Stefan P.
Zeevi, Tal
Baumeister, Philipp
Reichel, Christoph
Sharaf, Kariem
Forghani, Reza
Kann, Benjamin H.
Judson, Benjamin L.
Prasad, Manju L.
Burtness, Barbara
Mahajan, Amit
Payabvash, Seyedmehdi
author_facet Haider, Stefan P.
Zeevi, Tal
Baumeister, Philipp
Reichel, Christoph
Sharaf, Kariem
Forghani, Reza
Kann, Benjamin H.
Judson, Benjamin L.
Prasad, Manju L.
Burtness, Barbara
Mahajan, Amit
Payabvash, Seyedmehdi
author_sort Haider, Stefan P.
collection PubMed
description Accurate risk-stratification can facilitate precision therapy in oropharyngeal squamous cell carcinoma (OPSCC). We explored the potential added value of baseline positron emission tomography (PET)/computed tomography (CT) radiomic features for prognostication and risk stratification of OPSCC beyond the American Joint Committee on Cancer (AJCC) 8th edition staging scheme. Using institutional and publicly available datasets, we included OPSCC patients with known human papillomavirus (HPV) status, without baseline distant metastasis and treated with curative intent. We extracted 1037 PET and 1037 CT radiomic features quantifying lesion shape, imaging intensity, and texture patterns from primary tumors and metastatic cervical lymph nodes. Utilizing random forest algorithms, we devised novel machine-learning models for OPSCC progression-free survival (PFS) and overall survival (OS) using “radiomics” features, “AJCC” variables, and the “combined” set as input. We designed both single- (PET or CT) and combined-modality (PET/CT) models. Harrell’s C-index quantified survival model performance; risk stratification was evaluated in Kaplan–Meier analysis. A total of 311 patients were included. In HPV-associated OPSCC, the best “radiomics” model achieved an average C-index ± standard deviation of 0.62 ± 0.05 (p = 0.02) for PFS prediction, compared to 0.54 ± 0.06 (p = 0.32) utilizing “AJCC” variables. Radiomics-based risk-stratification of HPV-associated OPSCC was significant for PFS and OS. Similar trends were observed in HPV-negative OPSCC. In conclusion, radiomics imaging features extracted from pre-treatment PET/CT may provide complimentary information to the current AJCC staging scheme for survival prognostication and risk-stratification of HPV-associated OPSCC.
format Online
Article
Text
id pubmed-7407414
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-74074142020-08-25 Potential Added Value of PET/CT Radiomics for Survival Prognostication beyond AJCC 8th Edition Staging in Oropharyngeal Squamous Cell Carcinoma Haider, Stefan P. Zeevi, Tal Baumeister, Philipp Reichel, Christoph Sharaf, Kariem Forghani, Reza Kann, Benjamin H. Judson, Benjamin L. Prasad, Manju L. Burtness, Barbara Mahajan, Amit Payabvash, Seyedmehdi Cancers (Basel) Article Accurate risk-stratification can facilitate precision therapy in oropharyngeal squamous cell carcinoma (OPSCC). We explored the potential added value of baseline positron emission tomography (PET)/computed tomography (CT) radiomic features for prognostication and risk stratification of OPSCC beyond the American Joint Committee on Cancer (AJCC) 8th edition staging scheme. Using institutional and publicly available datasets, we included OPSCC patients with known human papillomavirus (HPV) status, without baseline distant metastasis and treated with curative intent. We extracted 1037 PET and 1037 CT radiomic features quantifying lesion shape, imaging intensity, and texture patterns from primary tumors and metastatic cervical lymph nodes. Utilizing random forest algorithms, we devised novel machine-learning models for OPSCC progression-free survival (PFS) and overall survival (OS) using “radiomics” features, “AJCC” variables, and the “combined” set as input. We designed both single- (PET or CT) and combined-modality (PET/CT) models. Harrell’s C-index quantified survival model performance; risk stratification was evaluated in Kaplan–Meier analysis. A total of 311 patients were included. In HPV-associated OPSCC, the best “radiomics” model achieved an average C-index ± standard deviation of 0.62 ± 0.05 (p = 0.02) for PFS prediction, compared to 0.54 ± 0.06 (p = 0.32) utilizing “AJCC” variables. Radiomics-based risk-stratification of HPV-associated OPSCC was significant for PFS and OS. Similar trends were observed in HPV-negative OPSCC. In conclusion, radiomics imaging features extracted from pre-treatment PET/CT may provide complimentary information to the current AJCC staging scheme for survival prognostication and risk-stratification of HPV-associated OPSCC. MDPI 2020-07-03 /pmc/articles/PMC7407414/ /pubmed/32635216 http://dx.doi.org/10.3390/cancers12071778 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Haider, Stefan P.
Zeevi, Tal
Baumeister, Philipp
Reichel, Christoph
Sharaf, Kariem
Forghani, Reza
Kann, Benjamin H.
Judson, Benjamin L.
Prasad, Manju L.
Burtness, Barbara
Mahajan, Amit
Payabvash, Seyedmehdi
Potential Added Value of PET/CT Radiomics for Survival Prognostication beyond AJCC 8th Edition Staging in Oropharyngeal Squamous Cell Carcinoma
title Potential Added Value of PET/CT Radiomics for Survival Prognostication beyond AJCC 8th Edition Staging in Oropharyngeal Squamous Cell Carcinoma
title_full Potential Added Value of PET/CT Radiomics for Survival Prognostication beyond AJCC 8th Edition Staging in Oropharyngeal Squamous Cell Carcinoma
title_fullStr Potential Added Value of PET/CT Radiomics for Survival Prognostication beyond AJCC 8th Edition Staging in Oropharyngeal Squamous Cell Carcinoma
title_full_unstemmed Potential Added Value of PET/CT Radiomics for Survival Prognostication beyond AJCC 8th Edition Staging in Oropharyngeal Squamous Cell Carcinoma
title_short Potential Added Value of PET/CT Radiomics for Survival Prognostication beyond AJCC 8th Edition Staging in Oropharyngeal Squamous Cell Carcinoma
title_sort potential added value of pet/ct radiomics for survival prognostication beyond ajcc 8th edition staging in oropharyngeal squamous cell carcinoma
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7407414/
https://www.ncbi.nlm.nih.gov/pubmed/32635216
http://dx.doi.org/10.3390/cancers12071778
work_keys_str_mv AT haiderstefanp potentialaddedvalueofpetctradiomicsforsurvivalprognosticationbeyondajcc8theditionstaginginoropharyngealsquamouscellcarcinoma
AT zeevital potentialaddedvalueofpetctradiomicsforsurvivalprognosticationbeyondajcc8theditionstaginginoropharyngealsquamouscellcarcinoma
AT baumeisterphilipp potentialaddedvalueofpetctradiomicsforsurvivalprognosticationbeyondajcc8theditionstaginginoropharyngealsquamouscellcarcinoma
AT reichelchristoph potentialaddedvalueofpetctradiomicsforsurvivalprognosticationbeyondajcc8theditionstaginginoropharyngealsquamouscellcarcinoma
AT sharafkariem potentialaddedvalueofpetctradiomicsforsurvivalprognosticationbeyondajcc8theditionstaginginoropharyngealsquamouscellcarcinoma
AT forghanireza potentialaddedvalueofpetctradiomicsforsurvivalprognosticationbeyondajcc8theditionstaginginoropharyngealsquamouscellcarcinoma
AT kannbenjaminh potentialaddedvalueofpetctradiomicsforsurvivalprognosticationbeyondajcc8theditionstaginginoropharyngealsquamouscellcarcinoma
AT judsonbenjaminl potentialaddedvalueofpetctradiomicsforsurvivalprognosticationbeyondajcc8theditionstaginginoropharyngealsquamouscellcarcinoma
AT prasadmanjul potentialaddedvalueofpetctradiomicsforsurvivalprognosticationbeyondajcc8theditionstaginginoropharyngealsquamouscellcarcinoma
AT burtnessbarbara potentialaddedvalueofpetctradiomicsforsurvivalprognosticationbeyondajcc8theditionstaginginoropharyngealsquamouscellcarcinoma
AT mahajanamit potentialaddedvalueofpetctradiomicsforsurvivalprognosticationbeyondajcc8theditionstaginginoropharyngealsquamouscellcarcinoma
AT payabvashseyedmehdi potentialaddedvalueofpetctradiomicsforsurvivalprognosticationbeyondajcc8theditionstaginginoropharyngealsquamouscellcarcinoma