COVID19 antibody detection using lateral flow assay tests in a cohort of convalescent plasma donors

OBJECTIVE: COVID19 has caused a global and ongoing pandemic. The need for population seroconversion data is apparent to monitor and respond to the pandemic. Using a lateral flow assay (LFA) testing platform, the seropositivity in 63 New York Blood Center (NYBC) Convelescent Plasma (CP) donor samples...

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Autores principales: Ragnesola, Brett, Jin, Daniel, Lamb, Christopher C., Shaz, Beth H., Hillyer, Christopher D., Luchsinger, Larry L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research Note
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7407441/
https://www.ncbi.nlm.nih.gov/pubmed/32762746
http://dx.doi.org/10.1186/s13104-020-05212-0
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author Ragnesola, Brett
Jin, Daniel
Lamb, Christopher C.
Shaz, Beth H.
Hillyer, Christopher D.
Luchsinger, Larry L.
author_facet Ragnesola, Brett
Jin, Daniel
Lamb, Christopher C.
Shaz, Beth H.
Hillyer, Christopher D.
Luchsinger, Larry L.
author_sort Ragnesola, Brett
collection PubMed
description OBJECTIVE: COVID19 has caused a global and ongoing pandemic. The need for population seroconversion data is apparent to monitor and respond to the pandemic. Using a lateral flow assay (LFA) testing platform, the seropositivity in 63 New York Blood Center (NYBC) Convelescent Plasma (CP) donor samples were evaluated for the presence of COVID19 specific IgG and IgM. RESULTS: CP donors showed diverse antibody result. Convalescent donor plasma contains SARS-CoV-2 specific antibodies. Weak antibody bands may identify low titer CP donors. LFA tests can identify antibody positive individuals that have recovered from COVID19. Confirming suspected cases using antibody detection could help inform the patient and the community as to the relative risk to future exposure and a better understanding of disease exposure.
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spelling pubmed-74074412020-08-06 COVID19 antibody detection using lateral flow assay tests in a cohort of convalescent plasma donors Ragnesola, Brett Jin, Daniel Lamb, Christopher C. Shaz, Beth H. Hillyer, Christopher D. Luchsinger, Larry L. BMC Res Notes Research Note OBJECTIVE: COVID19 has caused a global and ongoing pandemic. The need for population seroconversion data is apparent to monitor and respond to the pandemic. Using a lateral flow assay (LFA) testing platform, the seropositivity in 63 New York Blood Center (NYBC) Convelescent Plasma (CP) donor samples were evaluated for the presence of COVID19 specific IgG and IgM. RESULTS: CP donors showed diverse antibody result. Convalescent donor plasma contains SARS-CoV-2 specific antibodies. Weak antibody bands may identify low titer CP donors. LFA tests can identify antibody positive individuals that have recovered from COVID19. Confirming suspected cases using antibody detection could help inform the patient and the community as to the relative risk to future exposure and a better understanding of disease exposure. BioMed Central 2020-08-06 /pmc/articles/PMC7407441/ /pubmed/32762746 http://dx.doi.org/10.1186/s13104-020-05212-0 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research Note
Ragnesola, Brett
Jin, Daniel
Lamb, Christopher C.
Shaz, Beth H.
Hillyer, Christopher D.
Luchsinger, Larry L.
COVID19 antibody detection using lateral flow assay tests in a cohort of convalescent plasma donors
title COVID19 antibody detection using lateral flow assay tests in a cohort of convalescent plasma donors
title_full COVID19 antibody detection using lateral flow assay tests in a cohort of convalescent plasma donors
title_fullStr COVID19 antibody detection using lateral flow assay tests in a cohort of convalescent plasma donors
title_full_unstemmed COVID19 antibody detection using lateral flow assay tests in a cohort of convalescent plasma donors
title_short COVID19 antibody detection using lateral flow assay tests in a cohort of convalescent plasma donors
title_sort covid19 antibody detection using lateral flow assay tests in a cohort of convalescent plasma donors
topic Research Note
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7407441/
https://www.ncbi.nlm.nih.gov/pubmed/32762746
http://dx.doi.org/10.1186/s13104-020-05212-0
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