Molecular Basis of the Function of Transcriptional Enhancers

Transcriptional enhancers are major genomic elements that control gene activity in eukaryotes. Recent studies provided deeper insight into the temporal and spatial organization of transcription in the nucleus, the role of non-coding RNAs in the process, and the epigenetic control of gene expression....

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Detalles Bibliográficos
Autores principales: Ibragimov, Airat N., Bylino, Oleg V., Shidlovskii, Yulii V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7407508/
https://www.ncbi.nlm.nih.gov/pubmed/32635644
http://dx.doi.org/10.3390/cells9071620
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author Ibragimov, Airat N.
Bylino, Oleg V.
Shidlovskii, Yulii V.
author_facet Ibragimov, Airat N.
Bylino, Oleg V.
Shidlovskii, Yulii V.
author_sort Ibragimov, Airat N.
collection PubMed
description Transcriptional enhancers are major genomic elements that control gene activity in eukaryotes. Recent studies provided deeper insight into the temporal and spatial organization of transcription in the nucleus, the role of non-coding RNAs in the process, and the epigenetic control of gene expression. Thus, multiple molecular details of enhancer functioning were revealed. Here, we describe the recent data and models of molecular organization of enhancer-driven transcription.
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spelling pubmed-74075082020-08-25 Molecular Basis of the Function of Transcriptional Enhancers Ibragimov, Airat N. Bylino, Oleg V. Shidlovskii, Yulii V. Cells Review Transcriptional enhancers are major genomic elements that control gene activity in eukaryotes. Recent studies provided deeper insight into the temporal and spatial organization of transcription in the nucleus, the role of non-coding RNAs in the process, and the epigenetic control of gene expression. Thus, multiple molecular details of enhancer functioning were revealed. Here, we describe the recent data and models of molecular organization of enhancer-driven transcription. MDPI 2020-07-05 /pmc/articles/PMC7407508/ /pubmed/32635644 http://dx.doi.org/10.3390/cells9071620 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Ibragimov, Airat N.
Bylino, Oleg V.
Shidlovskii, Yulii V.
Molecular Basis of the Function of Transcriptional Enhancers
title Molecular Basis of the Function of Transcriptional Enhancers
title_full Molecular Basis of the Function of Transcriptional Enhancers
title_fullStr Molecular Basis of the Function of Transcriptional Enhancers
title_full_unstemmed Molecular Basis of the Function of Transcriptional Enhancers
title_short Molecular Basis of the Function of Transcriptional Enhancers
title_sort molecular basis of the function of transcriptional enhancers
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7407508/
https://www.ncbi.nlm.nih.gov/pubmed/32635644
http://dx.doi.org/10.3390/cells9071620
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