Cargando…
Advances in Tissue Engineering and Innovative Fabrication Techniques for 3-D-Structures: Translational Applications in Neurodegenerative Diseases
In the field of regenerative medicine applied to neurodegenerative diseases, one of the most important challenges is the obtainment of innovative scaffolds aimed at improving the development of new frontiers in stem-cell therapy. In recent years, additive manufacturing techniques have gained more an...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7407518/ https://www.ncbi.nlm.nih.gov/pubmed/32646008 http://dx.doi.org/10.3390/cells9071636 |
_version_ | 1783567639718658048 |
---|---|
author | Rey, Federica Barzaghini, Bianca Nardini, Alessandra Bordoni, Matteo Zuccotti, Gian Vincenzo Cereda, Cristina Raimondi, Manuela Teresa Carelli, Stephana |
author_facet | Rey, Federica Barzaghini, Bianca Nardini, Alessandra Bordoni, Matteo Zuccotti, Gian Vincenzo Cereda, Cristina Raimondi, Manuela Teresa Carelli, Stephana |
author_sort | Rey, Federica |
collection | PubMed |
description | In the field of regenerative medicine applied to neurodegenerative diseases, one of the most important challenges is the obtainment of innovative scaffolds aimed at improving the development of new frontiers in stem-cell therapy. In recent years, additive manufacturing techniques have gained more and more relevance proving the great potential of the fabrication of precision 3-D scaffolds. In this review, recent advances in additive manufacturing techniques are presented and discussed, with an overview on stimulus-triggered approaches, such as 3-D Printing and laser-based techniques, and deposition-based approaches. Innovative 3-D bioprinting techniques, which allow the production of cell/molecule-laden scaffolds, are becoming a promising frontier in disease modelling and therapy. In this context, the specific biomaterial, stiffness, precise geometrical patterns, and structural properties are to be considered of great relevance for their subsequent translational applications. Moreover, this work reports numerous recent advances in neural diseases modelling and specifically focuses on pre-clinical and clinical translation for scaffolding technology in multiple neurodegenerative diseases. |
format | Online Article Text |
id | pubmed-7407518 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-74075182020-08-25 Advances in Tissue Engineering and Innovative Fabrication Techniques for 3-D-Structures: Translational Applications in Neurodegenerative Diseases Rey, Federica Barzaghini, Bianca Nardini, Alessandra Bordoni, Matteo Zuccotti, Gian Vincenzo Cereda, Cristina Raimondi, Manuela Teresa Carelli, Stephana Cells Review In the field of regenerative medicine applied to neurodegenerative diseases, one of the most important challenges is the obtainment of innovative scaffolds aimed at improving the development of new frontiers in stem-cell therapy. In recent years, additive manufacturing techniques have gained more and more relevance proving the great potential of the fabrication of precision 3-D scaffolds. In this review, recent advances in additive manufacturing techniques are presented and discussed, with an overview on stimulus-triggered approaches, such as 3-D Printing and laser-based techniques, and deposition-based approaches. Innovative 3-D bioprinting techniques, which allow the production of cell/molecule-laden scaffolds, are becoming a promising frontier in disease modelling and therapy. In this context, the specific biomaterial, stiffness, precise geometrical patterns, and structural properties are to be considered of great relevance for their subsequent translational applications. Moreover, this work reports numerous recent advances in neural diseases modelling and specifically focuses on pre-clinical and clinical translation for scaffolding technology in multiple neurodegenerative diseases. MDPI 2020-07-07 /pmc/articles/PMC7407518/ /pubmed/32646008 http://dx.doi.org/10.3390/cells9071636 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Rey, Federica Barzaghini, Bianca Nardini, Alessandra Bordoni, Matteo Zuccotti, Gian Vincenzo Cereda, Cristina Raimondi, Manuela Teresa Carelli, Stephana Advances in Tissue Engineering and Innovative Fabrication Techniques for 3-D-Structures: Translational Applications in Neurodegenerative Diseases |
title | Advances in Tissue Engineering and Innovative Fabrication Techniques for 3-D-Structures: Translational Applications in Neurodegenerative Diseases |
title_full | Advances in Tissue Engineering and Innovative Fabrication Techniques for 3-D-Structures: Translational Applications in Neurodegenerative Diseases |
title_fullStr | Advances in Tissue Engineering and Innovative Fabrication Techniques for 3-D-Structures: Translational Applications in Neurodegenerative Diseases |
title_full_unstemmed | Advances in Tissue Engineering and Innovative Fabrication Techniques for 3-D-Structures: Translational Applications in Neurodegenerative Diseases |
title_short | Advances in Tissue Engineering and Innovative Fabrication Techniques for 3-D-Structures: Translational Applications in Neurodegenerative Diseases |
title_sort | advances in tissue engineering and innovative fabrication techniques for 3-d-structures: translational applications in neurodegenerative diseases |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7407518/ https://www.ncbi.nlm.nih.gov/pubmed/32646008 http://dx.doi.org/10.3390/cells9071636 |
work_keys_str_mv | AT reyfederica advancesintissueengineeringandinnovativefabricationtechniquesfor3dstructurestranslationalapplicationsinneurodegenerativediseases AT barzaghinibianca advancesintissueengineeringandinnovativefabricationtechniquesfor3dstructurestranslationalapplicationsinneurodegenerativediseases AT nardinialessandra advancesintissueengineeringandinnovativefabricationtechniquesfor3dstructurestranslationalapplicationsinneurodegenerativediseases AT bordonimatteo advancesintissueengineeringandinnovativefabricationtechniquesfor3dstructurestranslationalapplicationsinneurodegenerativediseases AT zuccottigianvincenzo advancesintissueengineeringandinnovativefabricationtechniquesfor3dstructurestranslationalapplicationsinneurodegenerativediseases AT ceredacristina advancesintissueengineeringandinnovativefabricationtechniquesfor3dstructurestranslationalapplicationsinneurodegenerativediseases AT raimondimanuelateresa advancesintissueengineeringandinnovativefabricationtechniquesfor3dstructurestranslationalapplicationsinneurodegenerativediseases AT carellistephana advancesintissueengineeringandinnovativefabricationtechniquesfor3dstructurestranslationalapplicationsinneurodegenerativediseases |