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Advances in Tissue Engineering and Innovative Fabrication Techniques for 3-D-Structures: Translational Applications in Neurodegenerative Diseases

In the field of regenerative medicine applied to neurodegenerative diseases, one of the most important challenges is the obtainment of innovative scaffolds aimed at improving the development of new frontiers in stem-cell therapy. In recent years, additive manufacturing techniques have gained more an...

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Autores principales: Rey, Federica, Barzaghini, Bianca, Nardini, Alessandra, Bordoni, Matteo, Zuccotti, Gian Vincenzo, Cereda, Cristina, Raimondi, Manuela Teresa, Carelli, Stephana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7407518/
https://www.ncbi.nlm.nih.gov/pubmed/32646008
http://dx.doi.org/10.3390/cells9071636
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author Rey, Federica
Barzaghini, Bianca
Nardini, Alessandra
Bordoni, Matteo
Zuccotti, Gian Vincenzo
Cereda, Cristina
Raimondi, Manuela Teresa
Carelli, Stephana
author_facet Rey, Federica
Barzaghini, Bianca
Nardini, Alessandra
Bordoni, Matteo
Zuccotti, Gian Vincenzo
Cereda, Cristina
Raimondi, Manuela Teresa
Carelli, Stephana
author_sort Rey, Federica
collection PubMed
description In the field of regenerative medicine applied to neurodegenerative diseases, one of the most important challenges is the obtainment of innovative scaffolds aimed at improving the development of new frontiers in stem-cell therapy. In recent years, additive manufacturing techniques have gained more and more relevance proving the great potential of the fabrication of precision 3-D scaffolds. In this review, recent advances in additive manufacturing techniques are presented and discussed, with an overview on stimulus-triggered approaches, such as 3-D Printing and laser-based techniques, and deposition-based approaches. Innovative 3-D bioprinting techniques, which allow the production of cell/molecule-laden scaffolds, are becoming a promising frontier in disease modelling and therapy. In this context, the specific biomaterial, stiffness, precise geometrical patterns, and structural properties are to be considered of great relevance for their subsequent translational applications. Moreover, this work reports numerous recent advances in neural diseases modelling and specifically focuses on pre-clinical and clinical translation for scaffolding technology in multiple neurodegenerative diseases.
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spelling pubmed-74075182020-08-25 Advances in Tissue Engineering and Innovative Fabrication Techniques for 3-D-Structures: Translational Applications in Neurodegenerative Diseases Rey, Federica Barzaghini, Bianca Nardini, Alessandra Bordoni, Matteo Zuccotti, Gian Vincenzo Cereda, Cristina Raimondi, Manuela Teresa Carelli, Stephana Cells Review In the field of regenerative medicine applied to neurodegenerative diseases, one of the most important challenges is the obtainment of innovative scaffolds aimed at improving the development of new frontiers in stem-cell therapy. In recent years, additive manufacturing techniques have gained more and more relevance proving the great potential of the fabrication of precision 3-D scaffolds. In this review, recent advances in additive manufacturing techniques are presented and discussed, with an overview on stimulus-triggered approaches, such as 3-D Printing and laser-based techniques, and deposition-based approaches. Innovative 3-D bioprinting techniques, which allow the production of cell/molecule-laden scaffolds, are becoming a promising frontier in disease modelling and therapy. In this context, the specific biomaterial, stiffness, precise geometrical patterns, and structural properties are to be considered of great relevance for their subsequent translational applications. Moreover, this work reports numerous recent advances in neural diseases modelling and specifically focuses on pre-clinical and clinical translation for scaffolding technology in multiple neurodegenerative diseases. MDPI 2020-07-07 /pmc/articles/PMC7407518/ /pubmed/32646008 http://dx.doi.org/10.3390/cells9071636 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Rey, Federica
Barzaghini, Bianca
Nardini, Alessandra
Bordoni, Matteo
Zuccotti, Gian Vincenzo
Cereda, Cristina
Raimondi, Manuela Teresa
Carelli, Stephana
Advances in Tissue Engineering and Innovative Fabrication Techniques for 3-D-Structures: Translational Applications in Neurodegenerative Diseases
title Advances in Tissue Engineering and Innovative Fabrication Techniques for 3-D-Structures: Translational Applications in Neurodegenerative Diseases
title_full Advances in Tissue Engineering and Innovative Fabrication Techniques for 3-D-Structures: Translational Applications in Neurodegenerative Diseases
title_fullStr Advances in Tissue Engineering and Innovative Fabrication Techniques for 3-D-Structures: Translational Applications in Neurodegenerative Diseases
title_full_unstemmed Advances in Tissue Engineering and Innovative Fabrication Techniques for 3-D-Structures: Translational Applications in Neurodegenerative Diseases
title_short Advances in Tissue Engineering and Innovative Fabrication Techniques for 3-D-Structures: Translational Applications in Neurodegenerative Diseases
title_sort advances in tissue engineering and innovative fabrication techniques for 3-d-structures: translational applications in neurodegenerative diseases
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7407518/
https://www.ncbi.nlm.nih.gov/pubmed/32646008
http://dx.doi.org/10.3390/cells9071636
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