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Micro/Nanorobot: A Promising Targeted Drug Delivery System
Micro/nanorobot, as a research field, has attracted interest in recent years. It has great potential in medical treatment, as it can be applied in targeted drug delivery, surgical operation, disease diagnosis, etc. Differently from traditional drug delivery, which relies on blood circulation to reac...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7407549/ https://www.ncbi.nlm.nih.gov/pubmed/32679772 http://dx.doi.org/10.3390/pharmaceutics12070665 |
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author | Hu, Mengyi Ge, Xuemei Chen, Xuan Mao, Wenwei Qian, Xiuping Yuan, Wei-En |
author_facet | Hu, Mengyi Ge, Xuemei Chen, Xuan Mao, Wenwei Qian, Xiuping Yuan, Wei-En |
author_sort | Hu, Mengyi |
collection | PubMed |
description | Micro/nanorobot, as a research field, has attracted interest in recent years. It has great potential in medical treatment, as it can be applied in targeted drug delivery, surgical operation, disease diagnosis, etc. Differently from traditional drug delivery, which relies on blood circulation to reach the target, the designed micro/nanorobots can move autonomously, which makes it possible to deliver drugs to the hard-to-reach areas. Micro/nanorobots were driven by exogenous power (magnetic fields, light energy, acoustic fields, electric fields, etc.) or endogenous power (chemical reaction energy). Cell-based micro/nanorobots and DNA origami without autonomous movement ability were also introduced in this article. Although micro/nanorobots have excellent prospects, the current research is mainly based on in vitro experiments; in vivo research is still in its infancy. Further biological experiments are required to verify in vivo drug delivery effects of micro/nanorobots. This paper mainly discusses the research status, challenges, and future development of micro/nanorobots. |
format | Online Article Text |
id | pubmed-7407549 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-74075492020-08-25 Micro/Nanorobot: A Promising Targeted Drug Delivery System Hu, Mengyi Ge, Xuemei Chen, Xuan Mao, Wenwei Qian, Xiuping Yuan, Wei-En Pharmaceutics Review Micro/nanorobot, as a research field, has attracted interest in recent years. It has great potential in medical treatment, as it can be applied in targeted drug delivery, surgical operation, disease diagnosis, etc. Differently from traditional drug delivery, which relies on blood circulation to reach the target, the designed micro/nanorobots can move autonomously, which makes it possible to deliver drugs to the hard-to-reach areas. Micro/nanorobots were driven by exogenous power (magnetic fields, light energy, acoustic fields, electric fields, etc.) or endogenous power (chemical reaction energy). Cell-based micro/nanorobots and DNA origami without autonomous movement ability were also introduced in this article. Although micro/nanorobots have excellent prospects, the current research is mainly based on in vitro experiments; in vivo research is still in its infancy. Further biological experiments are required to verify in vivo drug delivery effects of micro/nanorobots. This paper mainly discusses the research status, challenges, and future development of micro/nanorobots. MDPI 2020-07-15 /pmc/articles/PMC7407549/ /pubmed/32679772 http://dx.doi.org/10.3390/pharmaceutics12070665 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Hu, Mengyi Ge, Xuemei Chen, Xuan Mao, Wenwei Qian, Xiuping Yuan, Wei-En Micro/Nanorobot: A Promising Targeted Drug Delivery System |
title | Micro/Nanorobot: A Promising Targeted Drug Delivery System |
title_full | Micro/Nanorobot: A Promising Targeted Drug Delivery System |
title_fullStr | Micro/Nanorobot: A Promising Targeted Drug Delivery System |
title_full_unstemmed | Micro/Nanorobot: A Promising Targeted Drug Delivery System |
title_short | Micro/Nanorobot: A Promising Targeted Drug Delivery System |
title_sort | micro/nanorobot: a promising targeted drug delivery system |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7407549/ https://www.ncbi.nlm.nih.gov/pubmed/32679772 http://dx.doi.org/10.3390/pharmaceutics12070665 |
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