The Potential of MLN3651 in Combination with Selumetinib as a Treatment for Merlin-Deficient Meningioma

Meningioma is the most common primary intracranial tumour, and surgical resection is the main therapeutic option. Merlin is a tumour suppressor protein that is frequently mutated in meningioma. The activity of the E3 ubiquitin ligase complex, CRL4-DCAF1, and the Raf/MEK/ERK scaffold protein Kinase s...

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Detalles Bibliográficos
Autores principales: Lyons Rimmer, Jade, Ercolano, Emanuela, Baiz, Daniele, Makhija, Mahindra, Berger, Allison, Sells, Todd, Stroud, Steve, Hilton, David, Adams, Claire L., Hanemann, C Oliver
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7407567/
https://www.ncbi.nlm.nih.gov/pubmed/32629964
http://dx.doi.org/10.3390/cancers12071744

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