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Cytotoxic, Antioxidant, and Enzyme Inhibitory Properties of the Traditional Medicinal Plant Matthiola incana (L.) R. Br.

Matthiola incana (L.) R. Br. (Brassicaceae) is widely cultivated for ornamental purposes and utilized as a medicinal plant. In the present work, the hydroalcoholic extract from the aerial parts of this species has been evaluated in different bioassays in order to detect potential pharmacological app...

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Autores principales: Taviano, Maria Fernanda, Miceli, Natalizia, Acquaviva, Rosaria, Malfa, Giuseppe Antonio, Ragusa, Salvatore, Giordano, Deborah, Cásedas, Guillermo, Les, Francisco, López, Víctor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7407578/
https://www.ncbi.nlm.nih.gov/pubmed/32668697
http://dx.doi.org/10.3390/biology9070163
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author Taviano, Maria Fernanda
Miceli, Natalizia
Acquaviva, Rosaria
Malfa, Giuseppe Antonio
Ragusa, Salvatore
Giordano, Deborah
Cásedas, Guillermo
Les, Francisco
López, Víctor
author_facet Taviano, Maria Fernanda
Miceli, Natalizia
Acquaviva, Rosaria
Malfa, Giuseppe Antonio
Ragusa, Salvatore
Giordano, Deborah
Cásedas, Guillermo
Les, Francisco
López, Víctor
author_sort Taviano, Maria Fernanda
collection PubMed
description Matthiola incana (L.) R. Br. (Brassicaceae) is widely cultivated for ornamental purposes and utilized as a medicinal plant. In the present work, the hydroalcoholic extract from the aerial parts of this species has been evaluated in different bioassays in order to detect potential pharmacological applications. The cytotoxic capacity against the human colorectal adenocarcinoma (CaCo-2) and breast cancer (MCF-7) cell lines was tested using the MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay. The extract was investigated as a neuroprotective inhibitor of central nervous system (CNS) enzymes such as monoamine oxidase A, tyrosinase, acetylcholinesterase, and as a natural enzyme inhibitor of α-glucosidase and lipase involved in some metabolic disorders such as obesity or type 2 diabetes. The antioxidant ability was also evaluated in an enzymatic system (xanthine/xanthine oxidase assay). Results showed that the M. incana extract displayed moderate to low cytotoxicity vs. CaCo-2 cells. The extract acted as a superoxide radical scavenger and enzymatic inhibitor of monoamine oxidase A, tyrosinase, α-glucosidase, and lipase. The best results were found in the α-glucosidase assay, as M. incana hydroalcoholic extract was able to inhibit the enzyme α-glucosidase up to 100% without significant differences, compared to the antidiabetic drug acarbose. Matthiola incana has been demonstrated to exert different biological properties. These are important in order to consider this species as a source of bioactive compounds.
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spelling pubmed-74075782020-08-25 Cytotoxic, Antioxidant, and Enzyme Inhibitory Properties of the Traditional Medicinal Plant Matthiola incana (L.) R. Br. Taviano, Maria Fernanda Miceli, Natalizia Acquaviva, Rosaria Malfa, Giuseppe Antonio Ragusa, Salvatore Giordano, Deborah Cásedas, Guillermo Les, Francisco López, Víctor Biology (Basel) Article Matthiola incana (L.) R. Br. (Brassicaceae) is widely cultivated for ornamental purposes and utilized as a medicinal plant. In the present work, the hydroalcoholic extract from the aerial parts of this species has been evaluated in different bioassays in order to detect potential pharmacological applications. The cytotoxic capacity against the human colorectal adenocarcinoma (CaCo-2) and breast cancer (MCF-7) cell lines was tested using the MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay. The extract was investigated as a neuroprotective inhibitor of central nervous system (CNS) enzymes such as monoamine oxidase A, tyrosinase, acetylcholinesterase, and as a natural enzyme inhibitor of α-glucosidase and lipase involved in some metabolic disorders such as obesity or type 2 diabetes. The antioxidant ability was also evaluated in an enzymatic system (xanthine/xanthine oxidase assay). Results showed that the M. incana extract displayed moderate to low cytotoxicity vs. CaCo-2 cells. The extract acted as a superoxide radical scavenger and enzymatic inhibitor of monoamine oxidase A, tyrosinase, α-glucosidase, and lipase. The best results were found in the α-glucosidase assay, as M. incana hydroalcoholic extract was able to inhibit the enzyme α-glucosidase up to 100% without significant differences, compared to the antidiabetic drug acarbose. Matthiola incana has been demonstrated to exert different biological properties. These are important in order to consider this species as a source of bioactive compounds. MDPI 2020-07-13 /pmc/articles/PMC7407578/ /pubmed/32668697 http://dx.doi.org/10.3390/biology9070163 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Taviano, Maria Fernanda
Miceli, Natalizia
Acquaviva, Rosaria
Malfa, Giuseppe Antonio
Ragusa, Salvatore
Giordano, Deborah
Cásedas, Guillermo
Les, Francisco
López, Víctor
Cytotoxic, Antioxidant, and Enzyme Inhibitory Properties of the Traditional Medicinal Plant Matthiola incana (L.) R. Br.
title Cytotoxic, Antioxidant, and Enzyme Inhibitory Properties of the Traditional Medicinal Plant Matthiola incana (L.) R. Br.
title_full Cytotoxic, Antioxidant, and Enzyme Inhibitory Properties of the Traditional Medicinal Plant Matthiola incana (L.) R. Br.
title_fullStr Cytotoxic, Antioxidant, and Enzyme Inhibitory Properties of the Traditional Medicinal Plant Matthiola incana (L.) R. Br.
title_full_unstemmed Cytotoxic, Antioxidant, and Enzyme Inhibitory Properties of the Traditional Medicinal Plant Matthiola incana (L.) R. Br.
title_short Cytotoxic, Antioxidant, and Enzyme Inhibitory Properties of the Traditional Medicinal Plant Matthiola incana (L.) R. Br.
title_sort cytotoxic, antioxidant, and enzyme inhibitory properties of the traditional medicinal plant matthiola incana (l.) r. br.
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7407578/
https://www.ncbi.nlm.nih.gov/pubmed/32668697
http://dx.doi.org/10.3390/biology9070163
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