Cargando…
Resectability and Ablatability Criteria for the Treatment of Liver Only Colorectal Metastases: Multidisciplinary Consensus Document from the COLLISION Trial Group
The guidelines for metastatic colorectal cancer crudely state that the best local treatment should be selected from a ‘toolbox’ of techniques according to patient- and treatment-related factors. We created an interdisciplinary, consensus-based algorithm with specific resectability and ablatability c...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7407587/ https://www.ncbi.nlm.nih.gov/pubmed/32635230 http://dx.doi.org/10.3390/cancers12071779 |
_version_ | 1783567657222537216 |
---|---|
author | Nieuwenhuizen, Sanne Puijk, Robbert S. van den Bemd, Bente Aldrighetti, Luca Arntz, Mark van den Boezem, Peter B. Bruynzeel, Anna M. E. Burgmans, Mark C. de Cobelli, Francesco Coolsen, Marielle M. E. Dejong, Cornelis H. C. Derks, Sarah Diederik, Arjen van Duijvendijk, Peter Eker, Hasan H. Engelsman, Anton F. Erdmann, Joris I. Fütterer, Jurgen J. Geboers, Bart Groot, Gerie Haasbeek, Cornelis J. A. Janssen, Jan-Jaap de Jong, Koert P. Kater, G. Matthijs Kazemier, Geert Kruimer, Johan W. H. Leclercq, Wouter K. G. van der Leij, Christiaan Manusama, Eric R. Meier, Mark A. J. van der Meijs, Bram B. Melenhorst, Marleen C. A. M. Nielsen, Karin Nijkamp, Maarten W. Potters, Fons H. Prevoo, Warner Rietema, Floris J. Ruarus, Alette H. Ruiter, Simeon J. S. Schouten, Evelien A. C. Serafino, Gian Piero Sietses, Colin Swijnenburg, Rutger-Jan Timmer, Florentine E. F. Versteeg, Kathelijn S. Vink, Ted de Vries, Jan J. J. de Wilt, Johannes H. W. Zonderhuis, Barbara M. Scheffer, Hester J. van den Tol, Petrousjka M. P. Meijerink, Martijn R. |
author_facet | Nieuwenhuizen, Sanne Puijk, Robbert S. van den Bemd, Bente Aldrighetti, Luca Arntz, Mark van den Boezem, Peter B. Bruynzeel, Anna M. E. Burgmans, Mark C. de Cobelli, Francesco Coolsen, Marielle M. E. Dejong, Cornelis H. C. Derks, Sarah Diederik, Arjen van Duijvendijk, Peter Eker, Hasan H. Engelsman, Anton F. Erdmann, Joris I. Fütterer, Jurgen J. Geboers, Bart Groot, Gerie Haasbeek, Cornelis J. A. Janssen, Jan-Jaap de Jong, Koert P. Kater, G. Matthijs Kazemier, Geert Kruimer, Johan W. H. Leclercq, Wouter K. G. van der Leij, Christiaan Manusama, Eric R. Meier, Mark A. J. van der Meijs, Bram B. Melenhorst, Marleen C. A. M. Nielsen, Karin Nijkamp, Maarten W. Potters, Fons H. Prevoo, Warner Rietema, Floris J. Ruarus, Alette H. Ruiter, Simeon J. S. Schouten, Evelien A. C. Serafino, Gian Piero Sietses, Colin Swijnenburg, Rutger-Jan Timmer, Florentine E. F. Versteeg, Kathelijn S. Vink, Ted de Vries, Jan J. J. de Wilt, Johannes H. W. Zonderhuis, Barbara M. Scheffer, Hester J. van den Tol, Petrousjka M. P. Meijerink, Martijn R. |
author_sort | Nieuwenhuizen, Sanne |
collection | PubMed |
description | The guidelines for metastatic colorectal cancer crudely state that the best local treatment should be selected from a ‘toolbox’ of techniques according to patient- and treatment-related factors. We created an interdisciplinary, consensus-based algorithm with specific resectability and ablatability criteria for the treatment of colorectal liver metastases (CRLM). To pursue consensus, members of the multidisciplinary COLLISION and COLDFIRE trial expert panel employed the RAND appropriateness method (RAM). Statements regarding patient, disease, tumor and treatment characteristics were categorized as appropriate, equipoise or inappropriate. Patients with ECOG≤2, ASA≤3 and Charlson comorbidity index ≤8 should be considered fit for curative-intent local therapy. When easily resectable and/or ablatable (stage IVa), (neo)adjuvant systemic therapy is not indicated. When requiring major hepatectomy (stage IVb), neo-adjuvant systemic therapy is appropriate for early metachronous disease and to reduce procedural risk. To downstage patients (stage IVc), downsizing induction systemic therapy and/or future remnant augmentation is advised. Disease can only be deemed permanently unsuitable for local therapy if downstaging failed (stage IVd). Liver resection remains the gold standard. Thermal ablation is reserved for unresectable CRLM, deep-seated resectable CRLM and can be considered when patients are in poor health. Irreversible electroporation and stereotactic body radiotherapy can be considered for unresectable perihilar and perivascular CRLM 0-5cm. This consensus document provides per-patient and per-tumor resectability and ablatability criteria for the treatment of CRLM. These criteria are intended to aid tumor board discussions, improve consistency when designing prospective trials and advance intersociety communications. Areas where consensus is lacking warrant future comparative studies. |
format | Online Article Text |
id | pubmed-7407587 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-74075872020-08-25 Resectability and Ablatability Criteria for the Treatment of Liver Only Colorectal Metastases: Multidisciplinary Consensus Document from the COLLISION Trial Group Nieuwenhuizen, Sanne Puijk, Robbert S. van den Bemd, Bente Aldrighetti, Luca Arntz, Mark van den Boezem, Peter B. Bruynzeel, Anna M. E. Burgmans, Mark C. de Cobelli, Francesco Coolsen, Marielle M. E. Dejong, Cornelis H. C. Derks, Sarah Diederik, Arjen van Duijvendijk, Peter Eker, Hasan H. Engelsman, Anton F. Erdmann, Joris I. Fütterer, Jurgen J. Geboers, Bart Groot, Gerie Haasbeek, Cornelis J. A. Janssen, Jan-Jaap de Jong, Koert P. Kater, G. Matthijs Kazemier, Geert Kruimer, Johan W. H. Leclercq, Wouter K. G. van der Leij, Christiaan Manusama, Eric R. Meier, Mark A. J. van der Meijs, Bram B. Melenhorst, Marleen C. A. M. Nielsen, Karin Nijkamp, Maarten W. Potters, Fons H. Prevoo, Warner Rietema, Floris J. Ruarus, Alette H. Ruiter, Simeon J. S. Schouten, Evelien A. C. Serafino, Gian Piero Sietses, Colin Swijnenburg, Rutger-Jan Timmer, Florentine E. F. Versteeg, Kathelijn S. Vink, Ted de Vries, Jan J. J. de Wilt, Johannes H. W. Zonderhuis, Barbara M. Scheffer, Hester J. van den Tol, Petrousjka M. P. Meijerink, Martijn R. Cancers (Basel) Article The guidelines for metastatic colorectal cancer crudely state that the best local treatment should be selected from a ‘toolbox’ of techniques according to patient- and treatment-related factors. We created an interdisciplinary, consensus-based algorithm with specific resectability and ablatability criteria for the treatment of colorectal liver metastases (CRLM). To pursue consensus, members of the multidisciplinary COLLISION and COLDFIRE trial expert panel employed the RAND appropriateness method (RAM). Statements regarding patient, disease, tumor and treatment characteristics were categorized as appropriate, equipoise or inappropriate. Patients with ECOG≤2, ASA≤3 and Charlson comorbidity index ≤8 should be considered fit for curative-intent local therapy. When easily resectable and/or ablatable (stage IVa), (neo)adjuvant systemic therapy is not indicated. When requiring major hepatectomy (stage IVb), neo-adjuvant systemic therapy is appropriate for early metachronous disease and to reduce procedural risk. To downstage patients (stage IVc), downsizing induction systemic therapy and/or future remnant augmentation is advised. Disease can only be deemed permanently unsuitable for local therapy if downstaging failed (stage IVd). Liver resection remains the gold standard. Thermal ablation is reserved for unresectable CRLM, deep-seated resectable CRLM and can be considered when patients are in poor health. Irreversible electroporation and stereotactic body radiotherapy can be considered for unresectable perihilar and perivascular CRLM 0-5cm. This consensus document provides per-patient and per-tumor resectability and ablatability criteria for the treatment of CRLM. These criteria are intended to aid tumor board discussions, improve consistency when designing prospective trials and advance intersociety communications. Areas where consensus is lacking warrant future comparative studies. MDPI 2020-07-03 /pmc/articles/PMC7407587/ /pubmed/32635230 http://dx.doi.org/10.3390/cancers12071779 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Nieuwenhuizen, Sanne Puijk, Robbert S. van den Bemd, Bente Aldrighetti, Luca Arntz, Mark van den Boezem, Peter B. Bruynzeel, Anna M. E. Burgmans, Mark C. de Cobelli, Francesco Coolsen, Marielle M. E. Dejong, Cornelis H. C. Derks, Sarah Diederik, Arjen van Duijvendijk, Peter Eker, Hasan H. Engelsman, Anton F. Erdmann, Joris I. Fütterer, Jurgen J. Geboers, Bart Groot, Gerie Haasbeek, Cornelis J. A. Janssen, Jan-Jaap de Jong, Koert P. Kater, G. Matthijs Kazemier, Geert Kruimer, Johan W. H. Leclercq, Wouter K. G. van der Leij, Christiaan Manusama, Eric R. Meier, Mark A. J. van der Meijs, Bram B. Melenhorst, Marleen C. A. M. Nielsen, Karin Nijkamp, Maarten W. Potters, Fons H. Prevoo, Warner Rietema, Floris J. Ruarus, Alette H. Ruiter, Simeon J. S. Schouten, Evelien A. C. Serafino, Gian Piero Sietses, Colin Swijnenburg, Rutger-Jan Timmer, Florentine E. F. Versteeg, Kathelijn S. Vink, Ted de Vries, Jan J. J. de Wilt, Johannes H. W. Zonderhuis, Barbara M. Scheffer, Hester J. van den Tol, Petrousjka M. P. Meijerink, Martijn R. Resectability and Ablatability Criteria for the Treatment of Liver Only Colorectal Metastases: Multidisciplinary Consensus Document from the COLLISION Trial Group |
title | Resectability and Ablatability Criteria for the Treatment of Liver Only Colorectal Metastases: Multidisciplinary Consensus Document from the COLLISION Trial Group |
title_full | Resectability and Ablatability Criteria for the Treatment of Liver Only Colorectal Metastases: Multidisciplinary Consensus Document from the COLLISION Trial Group |
title_fullStr | Resectability and Ablatability Criteria for the Treatment of Liver Only Colorectal Metastases: Multidisciplinary Consensus Document from the COLLISION Trial Group |
title_full_unstemmed | Resectability and Ablatability Criteria for the Treatment of Liver Only Colorectal Metastases: Multidisciplinary Consensus Document from the COLLISION Trial Group |
title_short | Resectability and Ablatability Criteria for the Treatment of Liver Only Colorectal Metastases: Multidisciplinary Consensus Document from the COLLISION Trial Group |
title_sort | resectability and ablatability criteria for the treatment of liver only colorectal metastases: multidisciplinary consensus document from the collision trial group |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7407587/ https://www.ncbi.nlm.nih.gov/pubmed/32635230 http://dx.doi.org/10.3390/cancers12071779 |
work_keys_str_mv | AT nieuwenhuizensanne resectabilityandablatabilitycriteriaforthetreatmentofliveronlycolorectalmetastasesmultidisciplinaryconsensusdocumentfromthecollisiontrialgroup AT puijkrobberts resectabilityandablatabilitycriteriaforthetreatmentofliveronlycolorectalmetastasesmultidisciplinaryconsensusdocumentfromthecollisiontrialgroup AT vandenbemdbente resectabilityandablatabilitycriteriaforthetreatmentofliveronlycolorectalmetastasesmultidisciplinaryconsensusdocumentfromthecollisiontrialgroup AT aldrighettiluca resectabilityandablatabilitycriteriaforthetreatmentofliveronlycolorectalmetastasesmultidisciplinaryconsensusdocumentfromthecollisiontrialgroup AT arntzmark resectabilityandablatabilitycriteriaforthetreatmentofliveronlycolorectalmetastasesmultidisciplinaryconsensusdocumentfromthecollisiontrialgroup AT vandenboezempeterb resectabilityandablatabilitycriteriaforthetreatmentofliveronlycolorectalmetastasesmultidisciplinaryconsensusdocumentfromthecollisiontrialgroup AT bruynzeelanname resectabilityandablatabilitycriteriaforthetreatmentofliveronlycolorectalmetastasesmultidisciplinaryconsensusdocumentfromthecollisiontrialgroup AT burgmansmarkc resectabilityandablatabilitycriteriaforthetreatmentofliveronlycolorectalmetastasesmultidisciplinaryconsensusdocumentfromthecollisiontrialgroup AT decobellifrancesco resectabilityandablatabilitycriteriaforthetreatmentofliveronlycolorectalmetastasesmultidisciplinaryconsensusdocumentfromthecollisiontrialgroup AT coolsenmarielleme resectabilityandablatabilitycriteriaforthetreatmentofliveronlycolorectalmetastasesmultidisciplinaryconsensusdocumentfromthecollisiontrialgroup AT dejongcornelishc resectabilityandablatabilitycriteriaforthetreatmentofliveronlycolorectalmetastasesmultidisciplinaryconsensusdocumentfromthecollisiontrialgroup AT derkssarah resectabilityandablatabilitycriteriaforthetreatmentofliveronlycolorectalmetastasesmultidisciplinaryconsensusdocumentfromthecollisiontrialgroup AT diederikarjen resectabilityandablatabilitycriteriaforthetreatmentofliveronlycolorectalmetastasesmultidisciplinaryconsensusdocumentfromthecollisiontrialgroup AT vanduijvendijkpeter resectabilityandablatabilitycriteriaforthetreatmentofliveronlycolorectalmetastasesmultidisciplinaryconsensusdocumentfromthecollisiontrialgroup AT ekerhasanh resectabilityandablatabilitycriteriaforthetreatmentofliveronlycolorectalmetastasesmultidisciplinaryconsensusdocumentfromthecollisiontrialgroup AT engelsmanantonf resectabilityandablatabilitycriteriaforthetreatmentofliveronlycolorectalmetastasesmultidisciplinaryconsensusdocumentfromthecollisiontrialgroup AT erdmannjorisi resectabilityandablatabilitycriteriaforthetreatmentofliveronlycolorectalmetastasesmultidisciplinaryconsensusdocumentfromthecollisiontrialgroup AT futtererjurgenj resectabilityandablatabilitycriteriaforthetreatmentofliveronlycolorectalmetastasesmultidisciplinaryconsensusdocumentfromthecollisiontrialgroup AT geboersbart resectabilityandablatabilitycriteriaforthetreatmentofliveronlycolorectalmetastasesmultidisciplinaryconsensusdocumentfromthecollisiontrialgroup AT grootgerie resectabilityandablatabilitycriteriaforthetreatmentofliveronlycolorectalmetastasesmultidisciplinaryconsensusdocumentfromthecollisiontrialgroup AT haasbeekcornelisja resectabilityandablatabilitycriteriaforthetreatmentofliveronlycolorectalmetastasesmultidisciplinaryconsensusdocumentfromthecollisiontrialgroup AT janssenjanjaap resectabilityandablatabilitycriteriaforthetreatmentofliveronlycolorectalmetastasesmultidisciplinaryconsensusdocumentfromthecollisiontrialgroup AT dejongkoertp resectabilityandablatabilitycriteriaforthetreatmentofliveronlycolorectalmetastasesmultidisciplinaryconsensusdocumentfromthecollisiontrialgroup AT katergmatthijs resectabilityandablatabilitycriteriaforthetreatmentofliveronlycolorectalmetastasesmultidisciplinaryconsensusdocumentfromthecollisiontrialgroup AT kazemiergeert resectabilityandablatabilitycriteriaforthetreatmentofliveronlycolorectalmetastasesmultidisciplinaryconsensusdocumentfromthecollisiontrialgroup AT kruimerjohanwh resectabilityandablatabilitycriteriaforthetreatmentofliveronlycolorectalmetastasesmultidisciplinaryconsensusdocumentfromthecollisiontrialgroup AT leclercqwouterkg resectabilityandablatabilitycriteriaforthetreatmentofliveronlycolorectalmetastasesmultidisciplinaryconsensusdocumentfromthecollisiontrialgroup AT vanderleijchristiaan resectabilityandablatabilitycriteriaforthetreatmentofliveronlycolorectalmetastasesmultidisciplinaryconsensusdocumentfromthecollisiontrialgroup AT manusamaericr resectabilityandablatabilitycriteriaforthetreatmentofliveronlycolorectalmetastasesmultidisciplinaryconsensusdocumentfromthecollisiontrialgroup AT meiermarkaj resectabilityandablatabilitycriteriaforthetreatmentofliveronlycolorectalmetastasesmultidisciplinaryconsensusdocumentfromthecollisiontrialgroup AT vandermeijsbramb resectabilityandablatabilitycriteriaforthetreatmentofliveronlycolorectalmetastasesmultidisciplinaryconsensusdocumentfromthecollisiontrialgroup AT melenhorstmarleencam resectabilityandablatabilitycriteriaforthetreatmentofliveronlycolorectalmetastasesmultidisciplinaryconsensusdocumentfromthecollisiontrialgroup AT nielsenkarin resectabilityandablatabilitycriteriaforthetreatmentofliveronlycolorectalmetastasesmultidisciplinaryconsensusdocumentfromthecollisiontrialgroup AT nijkampmaartenw resectabilityandablatabilitycriteriaforthetreatmentofliveronlycolorectalmetastasesmultidisciplinaryconsensusdocumentfromthecollisiontrialgroup AT pottersfonsh resectabilityandablatabilitycriteriaforthetreatmentofliveronlycolorectalmetastasesmultidisciplinaryconsensusdocumentfromthecollisiontrialgroup AT prevoowarner resectabilityandablatabilitycriteriaforthetreatmentofliveronlycolorectalmetastasesmultidisciplinaryconsensusdocumentfromthecollisiontrialgroup AT rietemaflorisj resectabilityandablatabilitycriteriaforthetreatmentofliveronlycolorectalmetastasesmultidisciplinaryconsensusdocumentfromthecollisiontrialgroup AT ruarusaletteh resectabilityandablatabilitycriteriaforthetreatmentofliveronlycolorectalmetastasesmultidisciplinaryconsensusdocumentfromthecollisiontrialgroup AT ruitersimeonjs resectabilityandablatabilitycriteriaforthetreatmentofliveronlycolorectalmetastasesmultidisciplinaryconsensusdocumentfromthecollisiontrialgroup AT schoutenevelienac resectabilityandablatabilitycriteriaforthetreatmentofliveronlycolorectalmetastasesmultidisciplinaryconsensusdocumentfromthecollisiontrialgroup AT serafinogianpiero resectabilityandablatabilitycriteriaforthetreatmentofliveronlycolorectalmetastasesmultidisciplinaryconsensusdocumentfromthecollisiontrialgroup AT sietsescolin resectabilityandablatabilitycriteriaforthetreatmentofliveronlycolorectalmetastasesmultidisciplinaryconsensusdocumentfromthecollisiontrialgroup AT swijnenburgrutgerjan resectabilityandablatabilitycriteriaforthetreatmentofliveronlycolorectalmetastasesmultidisciplinaryconsensusdocumentfromthecollisiontrialgroup AT timmerflorentineef resectabilityandablatabilitycriteriaforthetreatmentofliveronlycolorectalmetastasesmultidisciplinaryconsensusdocumentfromthecollisiontrialgroup AT versteegkathelijns resectabilityandablatabilitycriteriaforthetreatmentofliveronlycolorectalmetastasesmultidisciplinaryconsensusdocumentfromthecollisiontrialgroup AT vinkted resectabilityandablatabilitycriteriaforthetreatmentofliveronlycolorectalmetastasesmultidisciplinaryconsensusdocumentfromthecollisiontrialgroup AT devriesjanjj resectabilityandablatabilitycriteriaforthetreatmentofliveronlycolorectalmetastasesmultidisciplinaryconsensusdocumentfromthecollisiontrialgroup AT dewiltjohanneshw resectabilityandablatabilitycriteriaforthetreatmentofliveronlycolorectalmetastasesmultidisciplinaryconsensusdocumentfromthecollisiontrialgroup AT zonderhuisbarbaram resectabilityandablatabilitycriteriaforthetreatmentofliveronlycolorectalmetastasesmultidisciplinaryconsensusdocumentfromthecollisiontrialgroup AT schefferhesterj resectabilityandablatabilitycriteriaforthetreatmentofliveronlycolorectalmetastasesmultidisciplinaryconsensusdocumentfromthecollisiontrialgroup AT vandentolpetrousjkamp resectabilityandablatabilitycriteriaforthetreatmentofliveronlycolorectalmetastasesmultidisciplinaryconsensusdocumentfromthecollisiontrialgroup AT meijerinkmartijnr resectabilityandablatabilitycriteriaforthetreatmentofliveronlycolorectalmetastasesmultidisciplinaryconsensusdocumentfromthecollisiontrialgroup |