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Effects of NAD(+) in Caenorhabditis elegans Models of Neuronal Damage
Nicotinamide adenine dinucleotide (NAD(+)) is an essential cofactor that mediates numerous biological processes in all living cells. Multiple NAD(+) biosynthetic enzymes and NAD(+)-consuming enzymes are involved in neuroprotection and axon regeneration. The nematode Caenorhabditis elegans has served...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7407593/ https://www.ncbi.nlm.nih.gov/pubmed/32630651 http://dx.doi.org/10.3390/biom10070993 |
Sumario: | Nicotinamide adenine dinucleotide (NAD(+)) is an essential cofactor that mediates numerous biological processes in all living cells. Multiple NAD(+) biosynthetic enzymes and NAD(+)-consuming enzymes are involved in neuroprotection and axon regeneration. The nematode Caenorhabditis elegans has served as a model to study the neuronal role of NAD(+) because many molecular components regulating NAD(+) are highly conserved. This review focuses on recent findings using C. elegans models of neuronal damage pertaining to the neuronal functions of NAD(+) and its precursors, including a neuroprotective role against excitotoxicity and axon degeneration as well as an inhibitory role in axon regeneration. The regulation of NAD(+) levels could be a promising therapeutic strategy to counter many neurodegenerative diseases, as well as neurotoxin-induced and traumatic neuronal damage. |
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