Assessment of health-related quality of life of male patients with ileal orthotopic neobladder compared to cutaneous ureterostomy

INTRODUCTION: The aim of this article was to compare patients’ health-related quality of life (HR-QoL) outcomes between ileal orthotopic neobladder (IONB) and standard bilateral cutaneous ureterostomy (CU) using validated diversion-specific HR-QoL questionnaires. MATERIAL AND METHODS: This study uti...

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Detalles Bibliográficos
Autores principales: Tsaturyan, Arman, Beglaryan, Mher, Kirakosyan, Yervand, Martirosyan, Davit, Mkhitaryan, Mher, Shahsuvaryan, Varujan, Fanarjyan, Sergey, Tsaturyan, Ashot
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Polish Urological Association 2020
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7407788/
https://www.ncbi.nlm.nih.gov/pubmed/32782835
http://dx.doi.org/10.5173/ceju.2020.0028
Descripción
Sumario:INTRODUCTION: The aim of this article was to compare patients’ health-related quality of life (HR-QoL) outcomes between ileal orthotopic neobladder (IONB) and standard bilateral cutaneous ureterostomy (CU) using validated diversion-specific HR-QoL questionnaires. MATERIAL AND METHODS: This study utilized a retrospective cohort design, including all male patients who underwent open radical cystectomy with either IONB or CU from January 2010 until December 2017. In total, 69 and 57 male patients with a minimum of 12 months of follow-up were included in each group respectively, after applying the following exclusion criteria: female, pre- and postoperative radio- and chemotherapy and palliative surgery. For every patient, HR-QoL was evaluated using the European Association of Research and Treatment of Cancer Quality of Life Core (EORTC-QLQ-C30) and Functional Assessment of Cancer Therapy for patients undergoing radical cystectomy (FACT-Bl-Cys) validated questionnaires. RESULTS: In multivariable analysis, the type of the urinary diversion, and the occurrence of early and late postoperative complications were independently associated with the change of scores of HR-QoL domains. When comparing the 2 surgical methods (IONB vs. CU), after adjusting for confounders, such EORTC-QLQ-C30 domains as physical functioning (66.5 vs. 57.9, p = 0.011) and global health status (58.1 vs. 42.6, p <0.001) were superior in the IONB arm which was statistically significant. Similarly, functional health (15.3 vs. 11.9, p <0.001) and total score (110.1 vs. 101.7, p = 0.009) from the FACT-Bl-Cys questionnaire were superior in the IONB arm. CONCLUSIONS: In our study, patients with IONB possessed statistically significant, better scores of HR-QoL domains assessed with EORTC-QLQ-C30 and FACT-Bl-Cys questionnaires compared to those with CU. The occurrence of early major and late complications negatively affected patients’ HR-QOL.

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