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Assessment of health-related quality of life of male patients with ileal orthotopic neobladder compared to cutaneous ureterostomy
INTRODUCTION: The aim of this article was to compare patients’ health-related quality of life (HR-QoL) outcomes between ileal orthotopic neobladder (IONB) and standard bilateral cutaneous ureterostomy (CU) using validated diversion-specific HR-QoL questionnaires. MATERIAL AND METHODS: This study uti...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Polish Urological Association
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7407788/ https://www.ncbi.nlm.nih.gov/pubmed/32782835 http://dx.doi.org/10.5173/ceju.2020.0028 |
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author | Tsaturyan, Arman Beglaryan, Mher Kirakosyan, Yervand Martirosyan, Davit Mkhitaryan, Mher Shahsuvaryan, Varujan Fanarjyan, Sergey Tsaturyan, Ashot |
author_facet | Tsaturyan, Arman Beglaryan, Mher Kirakosyan, Yervand Martirosyan, Davit Mkhitaryan, Mher Shahsuvaryan, Varujan Fanarjyan, Sergey Tsaturyan, Ashot |
author_sort | Tsaturyan, Arman |
collection | PubMed |
description | INTRODUCTION: The aim of this article was to compare patients’ health-related quality of life (HR-QoL) outcomes between ileal orthotopic neobladder (IONB) and standard bilateral cutaneous ureterostomy (CU) using validated diversion-specific HR-QoL questionnaires. MATERIAL AND METHODS: This study utilized a retrospective cohort design, including all male patients who underwent open radical cystectomy with either IONB or CU from January 2010 until December 2017. In total, 69 and 57 male patients with a minimum of 12 months of follow-up were included in each group respectively, after applying the following exclusion criteria: female, pre- and postoperative radio- and chemotherapy and palliative surgery. For every patient, HR-QoL was evaluated using the European Association of Research and Treatment of Cancer Quality of Life Core (EORTC-QLQ-C30) and Functional Assessment of Cancer Therapy for patients undergoing radical cystectomy (FACT-Bl-Cys) validated questionnaires. RESULTS: In multivariable analysis, the type of the urinary diversion, and the occurrence of early and late postoperative complications were independently associated with the change of scores of HR-QoL domains. When comparing the 2 surgical methods (IONB vs. CU), after adjusting for confounders, such EORTC-QLQ-C30 domains as physical functioning (66.5 vs. 57.9, p = 0.011) and global health status (58.1 vs. 42.6, p <0.001) were superior in the IONB arm which was statistically significant. Similarly, functional health (15.3 vs. 11.9, p <0.001) and total score (110.1 vs. 101.7, p = 0.009) from the FACT-Bl-Cys questionnaire were superior in the IONB arm. CONCLUSIONS: In our study, patients with IONB possessed statistically significant, better scores of HR-QoL domains assessed with EORTC-QLQ-C30 and FACT-Bl-Cys questionnaires compared to those with CU. The occurrence of early major and late complications negatively affected patients’ HR-QOL. |
format | Online Article Text |
id | pubmed-7407788 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Polish Urological Association |
record_format | MEDLINE/PubMed |
spelling | pubmed-74077882020-08-10 Assessment of health-related quality of life of male patients with ileal orthotopic neobladder compared to cutaneous ureterostomy Tsaturyan, Arman Beglaryan, Mher Kirakosyan, Yervand Martirosyan, Davit Mkhitaryan, Mher Shahsuvaryan, Varujan Fanarjyan, Sergey Tsaturyan, Ashot Cent European J Urol Original Paper INTRODUCTION: The aim of this article was to compare patients’ health-related quality of life (HR-QoL) outcomes between ileal orthotopic neobladder (IONB) and standard bilateral cutaneous ureterostomy (CU) using validated diversion-specific HR-QoL questionnaires. MATERIAL AND METHODS: This study utilized a retrospective cohort design, including all male patients who underwent open radical cystectomy with either IONB or CU from January 2010 until December 2017. In total, 69 and 57 male patients with a minimum of 12 months of follow-up were included in each group respectively, after applying the following exclusion criteria: female, pre- and postoperative radio- and chemotherapy and palliative surgery. For every patient, HR-QoL was evaluated using the European Association of Research and Treatment of Cancer Quality of Life Core (EORTC-QLQ-C30) and Functional Assessment of Cancer Therapy for patients undergoing radical cystectomy (FACT-Bl-Cys) validated questionnaires. RESULTS: In multivariable analysis, the type of the urinary diversion, and the occurrence of early and late postoperative complications were independently associated with the change of scores of HR-QoL domains. When comparing the 2 surgical methods (IONB vs. CU), after adjusting for confounders, such EORTC-QLQ-C30 domains as physical functioning (66.5 vs. 57.9, p = 0.011) and global health status (58.1 vs. 42.6, p <0.001) were superior in the IONB arm which was statistically significant. Similarly, functional health (15.3 vs. 11.9, p <0.001) and total score (110.1 vs. 101.7, p = 0.009) from the FACT-Bl-Cys questionnaire were superior in the IONB arm. CONCLUSIONS: In our study, patients with IONB possessed statistically significant, better scores of HR-QoL domains assessed with EORTC-QLQ-C30 and FACT-Bl-Cys questionnaires compared to those with CU. The occurrence of early major and late complications negatively affected patients’ HR-QOL. Polish Urological Association 2020-05-09 2020 /pmc/articles/PMC7407788/ /pubmed/32782835 http://dx.doi.org/10.5173/ceju.2020.0028 Text en Copyright by Polish Urological Association http://creativecommons.org/licenses/by-nc-sa/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License, allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license. |
spellingShingle | Original Paper Tsaturyan, Arman Beglaryan, Mher Kirakosyan, Yervand Martirosyan, Davit Mkhitaryan, Mher Shahsuvaryan, Varujan Fanarjyan, Sergey Tsaturyan, Ashot Assessment of health-related quality of life of male patients with ileal orthotopic neobladder compared to cutaneous ureterostomy |
title | Assessment of health-related quality of life of male patients with ileal orthotopic neobladder compared to cutaneous ureterostomy |
title_full | Assessment of health-related quality of life of male patients with ileal orthotopic neobladder compared to cutaneous ureterostomy |
title_fullStr | Assessment of health-related quality of life of male patients with ileal orthotopic neobladder compared to cutaneous ureterostomy |
title_full_unstemmed | Assessment of health-related quality of life of male patients with ileal orthotopic neobladder compared to cutaneous ureterostomy |
title_short | Assessment of health-related quality of life of male patients with ileal orthotopic neobladder compared to cutaneous ureterostomy |
title_sort | assessment of health-related quality of life of male patients with ileal orthotopic neobladder compared to cutaneous ureterostomy |
topic | Original Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7407788/ https://www.ncbi.nlm.nih.gov/pubmed/32782835 http://dx.doi.org/10.5173/ceju.2020.0028 |
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