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Effect of Edge-to-Edge Mitral Valve Repair on Chordal Strain: Fluid-Structure Interaction Simulations
Edge-to-edge repair for mitral valve regurgitation is being increasingly performed in high-surgical risk patients using minimally invasive mitral clipping devices. Known procedural complications include chordal rupture and mitral leaflet perforation. Hence, it is important to quantitatively evaluate...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7407795/ https://www.ncbi.nlm.nih.gov/pubmed/32708356 http://dx.doi.org/10.3390/biology9070173 |
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author | Toma, Milan Einstein, Daniel R. Kohli, Keshav Caroll, Sheridan L. Bloodworth, Charles H. Cochran, Richard P. Kunzelman, Karyn S. Yoganathan, Ajit P. |
author_facet | Toma, Milan Einstein, Daniel R. Kohli, Keshav Caroll, Sheridan L. Bloodworth, Charles H. Cochran, Richard P. Kunzelman, Karyn S. Yoganathan, Ajit P. |
author_sort | Toma, Milan |
collection | PubMed |
description | Edge-to-edge repair for mitral valve regurgitation is being increasingly performed in high-surgical risk patients using minimally invasive mitral clipping devices. Known procedural complications include chordal rupture and mitral leaflet perforation. Hence, it is important to quantitatively evaluate the effect of edge-to-edge repair on chordal integrity. in this study, we employ a computational mitral valve model to simulate functional mitral regurgitation (FMR) by creating papillary muscle displacement. Edge-to-edge repair is then modeled by simulated coaptation of the mid portion of the mitral leaflets. in the setting of simulated FMR, edge-to-edge repair was shown to sustain low regurgitant orifice area, until a two fold increase in the inter-papillary muscle distance as compared to the normal mitral valve. Strain in the chordae was evaluated near the papillary muscles and the leaflets. Following edge-to-edge repair, strain near the papillary muscles did not significantly change relative to the unrepaired valve, while strain near the leaflets increased significantly relative to the unrepaired valve. These data demonstrate the potential for computational simulations to aid in the pre-procedural evaluation of possible complications such as chordal rupture and leaflet perforation following percutaneous edge-to-edge repair. |
format | Online Article Text |
id | pubmed-7407795 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-74077952020-08-12 Effect of Edge-to-Edge Mitral Valve Repair on Chordal Strain: Fluid-Structure Interaction Simulations Toma, Milan Einstein, Daniel R. Kohli, Keshav Caroll, Sheridan L. Bloodworth, Charles H. Cochran, Richard P. Kunzelman, Karyn S. Yoganathan, Ajit P. Biology (Basel) Article Edge-to-edge repair for mitral valve regurgitation is being increasingly performed in high-surgical risk patients using minimally invasive mitral clipping devices. Known procedural complications include chordal rupture and mitral leaflet perforation. Hence, it is important to quantitatively evaluate the effect of edge-to-edge repair on chordal integrity. in this study, we employ a computational mitral valve model to simulate functional mitral regurgitation (FMR) by creating papillary muscle displacement. Edge-to-edge repair is then modeled by simulated coaptation of the mid portion of the mitral leaflets. in the setting of simulated FMR, edge-to-edge repair was shown to sustain low regurgitant orifice area, until a two fold increase in the inter-papillary muscle distance as compared to the normal mitral valve. Strain in the chordae was evaluated near the papillary muscles and the leaflets. Following edge-to-edge repair, strain near the papillary muscles did not significantly change relative to the unrepaired valve, while strain near the leaflets increased significantly relative to the unrepaired valve. These data demonstrate the potential for computational simulations to aid in the pre-procedural evaluation of possible complications such as chordal rupture and leaflet perforation following percutaneous edge-to-edge repair. MDPI 2020-07-18 /pmc/articles/PMC7407795/ /pubmed/32708356 http://dx.doi.org/10.3390/biology9070173 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Toma, Milan Einstein, Daniel R. Kohli, Keshav Caroll, Sheridan L. Bloodworth, Charles H. Cochran, Richard P. Kunzelman, Karyn S. Yoganathan, Ajit P. Effect of Edge-to-Edge Mitral Valve Repair on Chordal Strain: Fluid-Structure Interaction Simulations |
title | Effect of Edge-to-Edge Mitral Valve Repair on Chordal Strain: Fluid-Structure Interaction Simulations |
title_full | Effect of Edge-to-Edge Mitral Valve Repair on Chordal Strain: Fluid-Structure Interaction Simulations |
title_fullStr | Effect of Edge-to-Edge Mitral Valve Repair on Chordal Strain: Fluid-Structure Interaction Simulations |
title_full_unstemmed | Effect of Edge-to-Edge Mitral Valve Repair on Chordal Strain: Fluid-Structure Interaction Simulations |
title_short | Effect of Edge-to-Edge Mitral Valve Repair on Chordal Strain: Fluid-Structure Interaction Simulations |
title_sort | effect of edge-to-edge mitral valve repair on chordal strain: fluid-structure interaction simulations |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7407795/ https://www.ncbi.nlm.nih.gov/pubmed/32708356 http://dx.doi.org/10.3390/biology9070173 |
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