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A 3D-Printed Modular Microreservoir for Drug Delivery

Reservoir-based drug delivery microsystems have enabled novel and effective drug delivery concepts in recent decades. These systems typically comprise integrated storing and pumping components. Here we present a stand-alone, modular, thin, scalable, and refillable microreservoir platform as a storin...

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Autores principales: Forouzandeh, Farzad, Ahamed, Nuzhet N., Hsu, Meng-Chun, Walton, Joseph P., Frisina, Robert D., Borkholder, David A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7407798/
https://www.ncbi.nlm.nih.gov/pubmed/32629848
http://dx.doi.org/10.3390/mi11070648
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author Forouzandeh, Farzad
Ahamed, Nuzhet N.
Hsu, Meng-Chun
Walton, Joseph P.
Frisina, Robert D.
Borkholder, David A.
author_facet Forouzandeh, Farzad
Ahamed, Nuzhet N.
Hsu, Meng-Chun
Walton, Joseph P.
Frisina, Robert D.
Borkholder, David A.
author_sort Forouzandeh, Farzad
collection PubMed
description Reservoir-based drug delivery microsystems have enabled novel and effective drug delivery concepts in recent decades. These systems typically comprise integrated storing and pumping components. Here we present a stand-alone, modular, thin, scalable, and refillable microreservoir platform as a storing component of these microsystems for implantable and transdermal drug delivery. Three microreservoir capacities (1, 10, and 100 µL) were fabricated with 3 mm overall thickness using stereolithography 3D-printing technology, enabling the fabrication of the device structure comprising a storing area and a refill port. A thin, preformed dome-shaped storing membrane was created by the deposition of parylene-C over a polyethylene glycol sacrificial layer, creating a force-free membrane that causes zero forward flow and insignificant backward flow (2% of total volume) due to membrane force. A septum pre-compression concept was introduced that enabled the realization of a 1-mm-thick septa capable of ~65000 leak-free refill punctures under 100 kPa backpressure. The force-free storing membrane enables using normally-open micropumps for drug delivery, and potentially improves the efficiency and precision of normally-closed micropumps. The ultra-thin septum reduces the thickness of refillable drug delivery devices, and is capable of thousands of leak-free refills. This modular and scalable device can be used for drug delivery in different laboratory animals and humans, as a sampling device, and for lab-on-a-chip and point-of-care diagnostics applications.
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spelling pubmed-74077982020-08-12 A 3D-Printed Modular Microreservoir for Drug Delivery Forouzandeh, Farzad Ahamed, Nuzhet N. Hsu, Meng-Chun Walton, Joseph P. Frisina, Robert D. Borkholder, David A. Micromachines (Basel) Article Reservoir-based drug delivery microsystems have enabled novel and effective drug delivery concepts in recent decades. These systems typically comprise integrated storing and pumping components. Here we present a stand-alone, modular, thin, scalable, and refillable microreservoir platform as a storing component of these microsystems for implantable and transdermal drug delivery. Three microreservoir capacities (1, 10, and 100 µL) were fabricated with 3 mm overall thickness using stereolithography 3D-printing technology, enabling the fabrication of the device structure comprising a storing area and a refill port. A thin, preformed dome-shaped storing membrane was created by the deposition of parylene-C over a polyethylene glycol sacrificial layer, creating a force-free membrane that causes zero forward flow and insignificant backward flow (2% of total volume) due to membrane force. A septum pre-compression concept was introduced that enabled the realization of a 1-mm-thick septa capable of ~65000 leak-free refill punctures under 100 kPa backpressure. The force-free storing membrane enables using normally-open micropumps for drug delivery, and potentially improves the efficiency and precision of normally-closed micropumps. The ultra-thin septum reduces the thickness of refillable drug delivery devices, and is capable of thousands of leak-free refills. This modular and scalable device can be used for drug delivery in different laboratory animals and humans, as a sampling device, and for lab-on-a-chip and point-of-care diagnostics applications. MDPI 2020-06-30 /pmc/articles/PMC7407798/ /pubmed/32629848 http://dx.doi.org/10.3390/mi11070648 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Forouzandeh, Farzad
Ahamed, Nuzhet N.
Hsu, Meng-Chun
Walton, Joseph P.
Frisina, Robert D.
Borkholder, David A.
A 3D-Printed Modular Microreservoir for Drug Delivery
title A 3D-Printed Modular Microreservoir for Drug Delivery
title_full A 3D-Printed Modular Microreservoir for Drug Delivery
title_fullStr A 3D-Printed Modular Microreservoir for Drug Delivery
title_full_unstemmed A 3D-Printed Modular Microreservoir for Drug Delivery
title_short A 3D-Printed Modular Microreservoir for Drug Delivery
title_sort 3d-printed modular microreservoir for drug delivery
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7407798/
https://www.ncbi.nlm.nih.gov/pubmed/32629848
http://dx.doi.org/10.3390/mi11070648
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