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A 3D-Printed Modular Microreservoir for Drug Delivery
Reservoir-based drug delivery microsystems have enabled novel and effective drug delivery concepts in recent decades. These systems typically comprise integrated storing and pumping components. Here we present a stand-alone, modular, thin, scalable, and refillable microreservoir platform as a storin...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7407798/ https://www.ncbi.nlm.nih.gov/pubmed/32629848 http://dx.doi.org/10.3390/mi11070648 |
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author | Forouzandeh, Farzad Ahamed, Nuzhet N. Hsu, Meng-Chun Walton, Joseph P. Frisina, Robert D. Borkholder, David A. |
author_facet | Forouzandeh, Farzad Ahamed, Nuzhet N. Hsu, Meng-Chun Walton, Joseph P. Frisina, Robert D. Borkholder, David A. |
author_sort | Forouzandeh, Farzad |
collection | PubMed |
description | Reservoir-based drug delivery microsystems have enabled novel and effective drug delivery concepts in recent decades. These systems typically comprise integrated storing and pumping components. Here we present a stand-alone, modular, thin, scalable, and refillable microreservoir platform as a storing component of these microsystems for implantable and transdermal drug delivery. Three microreservoir capacities (1, 10, and 100 µL) were fabricated with 3 mm overall thickness using stereolithography 3D-printing technology, enabling the fabrication of the device structure comprising a storing area and a refill port. A thin, preformed dome-shaped storing membrane was created by the deposition of parylene-C over a polyethylene glycol sacrificial layer, creating a force-free membrane that causes zero forward flow and insignificant backward flow (2% of total volume) due to membrane force. A septum pre-compression concept was introduced that enabled the realization of a 1-mm-thick septa capable of ~65000 leak-free refill punctures under 100 kPa backpressure. The force-free storing membrane enables using normally-open micropumps for drug delivery, and potentially improves the efficiency and precision of normally-closed micropumps. The ultra-thin septum reduces the thickness of refillable drug delivery devices, and is capable of thousands of leak-free refills. This modular and scalable device can be used for drug delivery in different laboratory animals and humans, as a sampling device, and for lab-on-a-chip and point-of-care diagnostics applications. |
format | Online Article Text |
id | pubmed-7407798 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-74077982020-08-12 A 3D-Printed Modular Microreservoir for Drug Delivery Forouzandeh, Farzad Ahamed, Nuzhet N. Hsu, Meng-Chun Walton, Joseph P. Frisina, Robert D. Borkholder, David A. Micromachines (Basel) Article Reservoir-based drug delivery microsystems have enabled novel and effective drug delivery concepts in recent decades. These systems typically comprise integrated storing and pumping components. Here we present a stand-alone, modular, thin, scalable, and refillable microreservoir platform as a storing component of these microsystems for implantable and transdermal drug delivery. Three microreservoir capacities (1, 10, and 100 µL) were fabricated with 3 mm overall thickness using stereolithography 3D-printing technology, enabling the fabrication of the device structure comprising a storing area and a refill port. A thin, preformed dome-shaped storing membrane was created by the deposition of parylene-C over a polyethylene glycol sacrificial layer, creating a force-free membrane that causes zero forward flow and insignificant backward flow (2% of total volume) due to membrane force. A septum pre-compression concept was introduced that enabled the realization of a 1-mm-thick septa capable of ~65000 leak-free refill punctures under 100 kPa backpressure. The force-free storing membrane enables using normally-open micropumps for drug delivery, and potentially improves the efficiency and precision of normally-closed micropumps. The ultra-thin septum reduces the thickness of refillable drug delivery devices, and is capable of thousands of leak-free refills. This modular and scalable device can be used for drug delivery in different laboratory animals and humans, as a sampling device, and for lab-on-a-chip and point-of-care diagnostics applications. MDPI 2020-06-30 /pmc/articles/PMC7407798/ /pubmed/32629848 http://dx.doi.org/10.3390/mi11070648 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Forouzandeh, Farzad Ahamed, Nuzhet N. Hsu, Meng-Chun Walton, Joseph P. Frisina, Robert D. Borkholder, David A. A 3D-Printed Modular Microreservoir for Drug Delivery |
title | A 3D-Printed Modular Microreservoir for Drug Delivery |
title_full | A 3D-Printed Modular Microreservoir for Drug Delivery |
title_fullStr | A 3D-Printed Modular Microreservoir for Drug Delivery |
title_full_unstemmed | A 3D-Printed Modular Microreservoir for Drug Delivery |
title_short | A 3D-Printed Modular Microreservoir for Drug Delivery |
title_sort | 3d-printed modular microreservoir for drug delivery |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7407798/ https://www.ncbi.nlm.nih.gov/pubmed/32629848 http://dx.doi.org/10.3390/mi11070648 |
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