The Multifaceted Pyruvate Metabolism: Role of the Mitochondrial Pyruvate Carrier

Pyruvate, the end product of glycolysis, plays a major role in cell metabolism. Produced in the cytosol, it is oxidized in the mitochondria where it fuels the citric acid cycle and boosts oxidative phosphorylation. Its sole entry point into mitochondria is through the recently identified mitochondri...

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Autores principales: Zangari, Joséphine, Petrelli, Francesco, Maillot, Benoît, Martinou, Jean-Claude
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7407832/
https://www.ncbi.nlm.nih.gov/pubmed/32708919
http://dx.doi.org/10.3390/biom10071068
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author Zangari, Joséphine
Petrelli, Francesco
Maillot, Benoît
Martinou, Jean-Claude
author_facet Zangari, Joséphine
Petrelli, Francesco
Maillot, Benoît
Martinou, Jean-Claude
author_sort Zangari, Joséphine
collection PubMed
description Pyruvate, the end product of glycolysis, plays a major role in cell metabolism. Produced in the cytosol, it is oxidized in the mitochondria where it fuels the citric acid cycle and boosts oxidative phosphorylation. Its sole entry point into mitochondria is through the recently identified mitochondrial pyruvate carrier (MPC). In this review, we report the latest findings on the physiology of the MPC and we discuss how a dysfunctional MPC can lead to diverse pathologies, including neurodegenerative diseases, metabolic disorders, and cancer.
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spelling pubmed-74078322020-08-12 The Multifaceted Pyruvate Metabolism: Role of the Mitochondrial Pyruvate Carrier Zangari, Joséphine Petrelli, Francesco Maillot, Benoît Martinou, Jean-Claude Biomolecules Review Pyruvate, the end product of glycolysis, plays a major role in cell metabolism. Produced in the cytosol, it is oxidized in the mitochondria where it fuels the citric acid cycle and boosts oxidative phosphorylation. Its sole entry point into mitochondria is through the recently identified mitochondrial pyruvate carrier (MPC). In this review, we report the latest findings on the physiology of the MPC and we discuss how a dysfunctional MPC can lead to diverse pathologies, including neurodegenerative diseases, metabolic disorders, and cancer. MDPI 2020-07-17 /pmc/articles/PMC7407832/ /pubmed/32708919 http://dx.doi.org/10.3390/biom10071068 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Zangari, Joséphine
Petrelli, Francesco
Maillot, Benoît
Martinou, Jean-Claude
The Multifaceted Pyruvate Metabolism: Role of the Mitochondrial Pyruvate Carrier
title The Multifaceted Pyruvate Metabolism: Role of the Mitochondrial Pyruvate Carrier
title_full The Multifaceted Pyruvate Metabolism: Role of the Mitochondrial Pyruvate Carrier
title_fullStr The Multifaceted Pyruvate Metabolism: Role of the Mitochondrial Pyruvate Carrier
title_full_unstemmed The Multifaceted Pyruvate Metabolism: Role of the Mitochondrial Pyruvate Carrier
title_short The Multifaceted Pyruvate Metabolism: Role of the Mitochondrial Pyruvate Carrier
title_sort multifaceted pyruvate metabolism: role of the mitochondrial pyruvate carrier
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7407832/
https://www.ncbi.nlm.nih.gov/pubmed/32708919
http://dx.doi.org/10.3390/biom10071068
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