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Locally Applied Slow-Release of Minocycline Microspheres in the Treatment of Peri-Implant Mucositis: An Experimental In Vivo Study

Background: The objective of this is preclinical investigation was to evaluate the differential drug sustainability and pharmacodynamic properties of two local minocycline microsphere carriers: chitosan-coated alginate (CA) and poly(meth)acrylate-glycerin (PG). Methods: Four dental implants were pla...

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Autores principales: Yoon, Sung-Wook, Kim, Myong-Ji, Paeng, Kyeong-Won, Yu, Kyeong Ae, Lee, Chong-Kil, Song, Young Woo, Cha, Jae-Kook, Sanz, Mariano, Jung, Ui-Won
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7407908/
https://www.ncbi.nlm.nih.gov/pubmed/32708741
http://dx.doi.org/10.3390/pharmaceutics12070668
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author Yoon, Sung-Wook
Kim, Myong-Ji
Paeng, Kyeong-Won
Yu, Kyeong Ae
Lee, Chong-Kil
Song, Young Woo
Cha, Jae-Kook
Sanz, Mariano
Jung, Ui-Won
author_facet Yoon, Sung-Wook
Kim, Myong-Ji
Paeng, Kyeong-Won
Yu, Kyeong Ae
Lee, Chong-Kil
Song, Young Woo
Cha, Jae-Kook
Sanz, Mariano
Jung, Ui-Won
author_sort Yoon, Sung-Wook
collection PubMed
description Background: The objective of this is preclinical investigation was to evaluate the differential drug sustainability and pharmacodynamic properties of two local minocycline microsphere carriers: chitosan-coated alginate (CA) and poly(meth)acrylate-glycerin (PG). Methods: Four dental implants were placed unilaterally in the edentulous mandible of six beagle dogs. Each implant was randomly assigned to receive one of the following four treatments: (i) CA (CA-based minocycline), (ii) placebo (CA substrate without minocycline), (iii) PG (PG-based minocycline) and (iv) control (mechanical debridement only). After inducing peri-implant mucositis, the randomly assigned treatments were administered into the gingival sulcus twice at a 4-week interval using a plastic-tipped syringe. Drug sustainability and pharmacodynamic (clinical, radiographical and cell marker intensity) evaluations were performed after each administration. Results: The CA microspheres remained longer around the healing abutment compared to the PG microspheres at both administrations and a longer bacteriostatic effect was observed from CA (7.0 ± 5.7 days) compared to PG (1.2 ± 2.6 days). The efficacy of the applied therapies based on clinical, radiographical and histological analyses were comparable across all treatment groups. Conclusions: CA microspheres showed longer carrier and bacteriostatic effect sustainability when compared to PG microspheres, however, longer drug sustainability did not lead to improved treatment outcomes.
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spelling pubmed-74079082020-08-12 Locally Applied Slow-Release of Minocycline Microspheres in the Treatment of Peri-Implant Mucositis: An Experimental In Vivo Study Yoon, Sung-Wook Kim, Myong-Ji Paeng, Kyeong-Won Yu, Kyeong Ae Lee, Chong-Kil Song, Young Woo Cha, Jae-Kook Sanz, Mariano Jung, Ui-Won Pharmaceutics Article Background: The objective of this is preclinical investigation was to evaluate the differential drug sustainability and pharmacodynamic properties of two local minocycline microsphere carriers: chitosan-coated alginate (CA) and poly(meth)acrylate-glycerin (PG). Methods: Four dental implants were placed unilaterally in the edentulous mandible of six beagle dogs. Each implant was randomly assigned to receive one of the following four treatments: (i) CA (CA-based minocycline), (ii) placebo (CA substrate without minocycline), (iii) PG (PG-based minocycline) and (iv) control (mechanical debridement only). After inducing peri-implant mucositis, the randomly assigned treatments were administered into the gingival sulcus twice at a 4-week interval using a plastic-tipped syringe. Drug sustainability and pharmacodynamic (clinical, radiographical and cell marker intensity) evaluations were performed after each administration. Results: The CA microspheres remained longer around the healing abutment compared to the PG microspheres at both administrations and a longer bacteriostatic effect was observed from CA (7.0 ± 5.7 days) compared to PG (1.2 ± 2.6 days). The efficacy of the applied therapies based on clinical, radiographical and histological analyses were comparable across all treatment groups. Conclusions: CA microspheres showed longer carrier and bacteriostatic effect sustainability when compared to PG microspheres, however, longer drug sustainability did not lead to improved treatment outcomes. MDPI 2020-07-16 /pmc/articles/PMC7407908/ /pubmed/32708741 http://dx.doi.org/10.3390/pharmaceutics12070668 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Yoon, Sung-Wook
Kim, Myong-Ji
Paeng, Kyeong-Won
Yu, Kyeong Ae
Lee, Chong-Kil
Song, Young Woo
Cha, Jae-Kook
Sanz, Mariano
Jung, Ui-Won
Locally Applied Slow-Release of Minocycline Microspheres in the Treatment of Peri-Implant Mucositis: An Experimental In Vivo Study
title Locally Applied Slow-Release of Minocycline Microspheres in the Treatment of Peri-Implant Mucositis: An Experimental In Vivo Study
title_full Locally Applied Slow-Release of Minocycline Microspheres in the Treatment of Peri-Implant Mucositis: An Experimental In Vivo Study
title_fullStr Locally Applied Slow-Release of Minocycline Microspheres in the Treatment of Peri-Implant Mucositis: An Experimental In Vivo Study
title_full_unstemmed Locally Applied Slow-Release of Minocycline Microspheres in the Treatment of Peri-Implant Mucositis: An Experimental In Vivo Study
title_short Locally Applied Slow-Release of Minocycline Microspheres in the Treatment of Peri-Implant Mucositis: An Experimental In Vivo Study
title_sort locally applied slow-release of minocycline microspheres in the treatment of peri-implant mucositis: an experimental in vivo study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7407908/
https://www.ncbi.nlm.nih.gov/pubmed/32708741
http://dx.doi.org/10.3390/pharmaceutics12070668
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