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A Novel Small-Molecule Inhibitor of Endosomal TLRs Reduces Inflammation and Alleviates Autoimmune Disease Symptoms in Murine Models

Toll-like receptors (TLRs) play a fundamental role in the inflammatory response against invading pathogens. However, the dysregulation of TLR-signaling pathways is implicated in several autoimmune/inflammatory diseases. Here, we show that a novel small molecule TLR-inhibitor (TAC5) and its derivativ...

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Detalles Bibliográficos
Autores principales:	Patra, Mahesh Chandra, Achek, Asma, Kim, Gi-Young, Panneerselvam, Suresh, Shin, Hyeon-Jun, Baek, Wook-Yong, Lee, Wang Hee, Sung, June, Jeong, Uisuk, Cho, Eun-Young, Kim, Wook, Kim, Eunha, Suh, Chang-Hee, Choi, Sangdun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7407930/ https://www.ncbi.nlm.nih.gov/pubmed/32660060 http://dx.doi.org/10.3390/cells9071648

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