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Mild Cognitive Impairments Attenuate Prefrontal Cortex Activations during Walking in Older Adults

The presence of Mild Cognitive Impairments (MCI) is associated with worse gait performance. However, the effect of MCI on cortical control of gait, as assessed during active walking, is unknown. We hypothesized that MCI would be associated with attenuated activations and limited improvement in effic...

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Autores principales: Holtzer, Roee, Izzetoglu, Meltem
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7407944/
https://www.ncbi.nlm.nih.gov/pubmed/32630216
http://dx.doi.org/10.3390/brainsci10070415
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author Holtzer, Roee
Izzetoglu, Meltem
author_facet Holtzer, Roee
Izzetoglu, Meltem
author_sort Holtzer, Roee
collection PubMed
description The presence of Mild Cognitive Impairments (MCI) is associated with worse gait performance. However, the effect of MCI on cortical control of gait, as assessed during active walking, is unknown. We hypothesized that MCI would be associated with attenuated activations and limited improvement in efficiency in the Prefrontal cortex (PFC) under cognitively-demanding walking conditions. Functional Near-Infrared Spectroscopy (fNIRS) was used to assess Oxygenated Hemoglobin (HbO(2)) in the PFC during Single-Task-Walk (STW), cognitive interference (Alpha) and Dual-Task-Walk (DTW) conditions. Three repeated trials in each experimental condition were administered. Healthy control (n = 71; mean age = 76.82 ± 6.21 years; %female = 50.7) and MCI (n = 11; mean age = 78.27 ± 4.31 years; %female = 45.5) participants were included. The increase in HbO(2) from STW to DTW was attenuated among MCI participants compared to controls (estimate = 0.505; p = 0.001). Whereas, among controls, HbO(2) increased from Alpha to DTW, the opposite was observed among MCI participants (estimate = 0.903; p < 0.001). In DTW, the decline in HbO(2) from trial 1 to 2 was attenuated in MCI participants compared to controls (estimate = 0.397; p = 0.008). Moreover, whereas HbO(2) declined from trial 1 to 3 among controls, MCI participants showed the opposite trend (estimate = 0.946; p < 0.001). MCI was associated with attenuated brain activation patterns and compromised ability to improve PFC efficiency during dual-task walking.
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spelling pubmed-74079442020-08-12 Mild Cognitive Impairments Attenuate Prefrontal Cortex Activations during Walking in Older Adults Holtzer, Roee Izzetoglu, Meltem Brain Sci Article The presence of Mild Cognitive Impairments (MCI) is associated with worse gait performance. However, the effect of MCI on cortical control of gait, as assessed during active walking, is unknown. We hypothesized that MCI would be associated with attenuated activations and limited improvement in efficiency in the Prefrontal cortex (PFC) under cognitively-demanding walking conditions. Functional Near-Infrared Spectroscopy (fNIRS) was used to assess Oxygenated Hemoglobin (HbO(2)) in the PFC during Single-Task-Walk (STW), cognitive interference (Alpha) and Dual-Task-Walk (DTW) conditions. Three repeated trials in each experimental condition were administered. Healthy control (n = 71; mean age = 76.82 ± 6.21 years; %female = 50.7) and MCI (n = 11; mean age = 78.27 ± 4.31 years; %female = 45.5) participants were included. The increase in HbO(2) from STW to DTW was attenuated among MCI participants compared to controls (estimate = 0.505; p = 0.001). Whereas, among controls, HbO(2) increased from Alpha to DTW, the opposite was observed among MCI participants (estimate = 0.903; p < 0.001). In DTW, the decline in HbO(2) from trial 1 to 2 was attenuated in MCI participants compared to controls (estimate = 0.397; p = 0.008). Moreover, whereas HbO(2) declined from trial 1 to 3 among controls, MCI participants showed the opposite trend (estimate = 0.946; p < 0.001). MCI was associated with attenuated brain activation patterns and compromised ability to improve PFC efficiency during dual-task walking. MDPI 2020-07-01 /pmc/articles/PMC7407944/ /pubmed/32630216 http://dx.doi.org/10.3390/brainsci10070415 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Holtzer, Roee
Izzetoglu, Meltem
Mild Cognitive Impairments Attenuate Prefrontal Cortex Activations during Walking in Older Adults
title Mild Cognitive Impairments Attenuate Prefrontal Cortex Activations during Walking in Older Adults
title_full Mild Cognitive Impairments Attenuate Prefrontal Cortex Activations during Walking in Older Adults
title_fullStr Mild Cognitive Impairments Attenuate Prefrontal Cortex Activations during Walking in Older Adults
title_full_unstemmed Mild Cognitive Impairments Attenuate Prefrontal Cortex Activations during Walking in Older Adults
title_short Mild Cognitive Impairments Attenuate Prefrontal Cortex Activations during Walking in Older Adults
title_sort mild cognitive impairments attenuate prefrontal cortex activations during walking in older adults
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7407944/
https://www.ncbi.nlm.nih.gov/pubmed/32630216
http://dx.doi.org/10.3390/brainsci10070415
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