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Porous Nanostructure, Lipid Composition, and Degree of Drug Supersaturation Modulate In Vitro Fenofibrate Solubilization in Silica-Lipid Hybrids

The unique nanostructured matrix obtained by silica-lipid hybrids (SLHs) is well known to improve the dissolution, absorption, and bioavailability of poorly water-soluble drugs (PWSDs). The aim of this study was to investigate the impact of: (i) drug load: 3–22.7% w/w, (ii) lipid type: medium-chain...

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Detalles Bibliográficos
Autores principales:	Almasri, Ruba, Joyce, Paul, Schultz, Hayley B., Thomas, Nicky, Bremmell, Kristen E., Prestidge, Clive A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7408050/ https://www.ncbi.nlm.nih.gov/pubmed/32708197 http://dx.doi.org/10.3390/pharmaceutics12070687

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