Cargando…

Pharmacokinetic Interaction between Sorafenib and Atorvastatin, and Sorafenib and Metformin in Rats

The tyrosine kinase inhibitor sorafenib is the first-line treatment for patients with hepatocellular carcinoma (HCC), in which hyperlipidemia and type 2 diabetes mellitus (T2DM) may often coexist. Protein transporters like organic cation (OCT) and multidrug and toxin extrusion (MATE) are involved in...

Descripción completa

Detalles Bibliográficos
Autores principales:	Karbownik, Agnieszka, Szkutnik-Fiedler, Danuta, Czyrski, Andrzej, Kostewicz, Natalia, Kaczmarska, Paulina, Bekier, Małgorzata, Stanisławiak-Rudowicz, Joanna, Karaźniewicz-Łada, Marta, Wolc, Anna, Główka, Franciszek, Grześkowiak, Edmund, Szałek, Edyta
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7408095/ https://www.ncbi.nlm.nih.gov/pubmed/32605304 http://dx.doi.org/10.3390/pharmaceutics12070600

Ejemplares similares

Pharmacokinetic Drug Interaction Study of Sorafenib and Morphine in Rats
por: Karbownik, Agnieszka, et al.
Publicado: (2021)

In vivo assessment of the drug interaction between sorafenib and paracetamol in rats
por: Karbownik, Agnieszka, et al.
Publicado: (2020)

The Influence of Paracetamol on the Penetration of Sorafenib and Sorafenib N-Oxide Through the Blood–Brain Barrier in Rats
por: Karbownik, Agnieszka, et al.
Publicado: (2020)

The oxidation and hypoglycaemic effect of sorafenib in streptozotocin-induced diabetic rats
por: Karbownik, Agnieszka, et al.
Publicado: (2020)

Correction to: The oxidation and hypoglycaemic effect of sorafenib in streptozotocin-induced diabetic rats
por: Karbownik, Agnieszka, et al.
Publicado: (2021)

Clinical pharmacokinetics of ketoprofen enantiomers in wild type of Cyp 2c8 and Cyp 2c9 patients with rheumatoid arthritis
por: Główka, Franciszek, et al.
Publicado: (2011)

The Influence of Diabetes Mellitus on Glucuronidation and Sulphation of Paracetamol in Patients with Febrile Neutropenia
por: Stachowiak, Anna, et al.
Publicado: (2018)

The effect of sunitinib on the plasma exposure of intravenous paracetamol and its major metabolite: paracetamol glucuronide
por: Karbownik, Agnieszka, et al.
Publicado: (2014)

Assessment of the Risk of Rhabdomyolysis and Myopathy During Concomitant Treatment with Ticagrelor and Statins
por: Danielak, Dorota, et al.
Publicado: (2018)

The physical and chemical stability of cisplatin (Teva) in concentrate and diluted in sodium chloride 0.9%
por: Karbownik, Agnieszka, et al.
Publicado: (2012)

Pharmacokinetic Drug–Drug Interactions among Antiepileptic Drugs, Including CBD, Drugs Used to Treat COVID-19 and Nutrients
por: Karaźniewicz-Łada, Marta, et al.
Publicado: (2021)

Phase I Study Evaluating Dose De-escalation of Sorafenib with Metformin and Atorvastatin in Hepatocellular Carcinoma (SMASH)
por: Ostwal, Vikas, et al.
Publicado: (2022)

The concomitant use of lapatinib and paracetamol - the risk of interaction
por: Karbownik, Agnieszka, et al.
Publicado: (2018)

The influence of the coadministration of the p-glycoprotein modulator elacridar on the pharmacokinetics of lapatinib and its distribution in the brain and cerebrospinal fluid
por: Karbownik, Agnieszka, et al.
Publicado: (2019)

Metabolic Characteristics of Hashimoto’s Thyroiditis Patients and the Role of Microelements and Diet in the Disease Management—An Overview
por: Mikulska, Aniceta A., et al.
Publicado: (2022)

Vitamin D Receptor Gene Polymorphism and Vitamin D Status in Population of Patients with Cardiovascular Disease—A Preliminary Study
por: Abouzid, Mohamed, et al.
Publicado: (2021)

Clinical Pharmacokinetics of Clopidogrel and Its Metabolites in Patients with Cardiovascular Diseases
por: Karaźniewicz-Łada, Marta, et al.
Publicado: (2013)

Impact of CYP3A4*1G Allele on Clinical Pharmacokinetics and Pharmacodynamics of Clopidogrel
por: Danielak, Dorota, et al.
Publicado: (2016)

Sorafenib synergizes with metformin in NSCLC through AMPK pathway activation
por: Groenendijk, Floris H, et al.
Publicado: (2015)

The Overview on the Pharmacokinetic and Pharmacodynamic Interactions of Triazoles
por: Czyrski, Andrzej, et al.
Publicado: (2021)

Influence of genetic co-factors on the population pharmacokinetic model for clopidogrel and its active thiol metabolite
por: Danielak, Dorota, et al.
Publicado: (2017)

HPLC Analysis of the Urinary Iodine Concentration in Pregnant Women
por: Mikulska, Aniceta A., et al.
Publicado: (2021)

Sorafenib Rechallenge and Sorafenib after Lenvatinib Failure in a Patient with Hepatocellular Carcinoma
por: Ikeda, Atsuyuki, et al.
Publicado: (2021)

Metformin inhibits the prometastatic effect of sorafenib in hepatocellular carcinoma by upregulating the expression of TIP30
por: Guo, Zhigui, et al.
Publicado: (2016)

Synergistic effect of metformin on sorafenib in in vitro study using hepatocellular carcinoma cell lines
por: Chung, Yong-Gyu, et al.
Publicado: (2018)

Metformin Resensitizes Sorafenib-Resistant HCC Cells Through AMPK-Dependent Autophagy Activation
por: Lai, Hong-Yue, et al.
Publicado: (2021)

Clinical Significance of Analysis of Vitamin D Status in Various Diseases
por: Kowalówka, Magdalena, et al.
Publicado: (2020)

Population Pharmacokinetic Modelling and Simulation to Determine the Optimal Dose of Nanoparticulated Sorafenib to the Reference Sorafenib
por: Huh, Ki-Young, et al.
Publicado: (2021)

Sorafenib in Molecularly Selected Cancer Patients: Final Analysis of the MOST-Plus Sorafenib Cohort
por: Trédan, Olivier, et al.
Publicado: (2023)

Effectiveness of Sorafenib in Hepatic Hemangioma
por: Tiwari, Prateek, et al.
Publicado: (2017)

Sorafenib as an Inhibitor of RUVBL2
por: Nano, Nardin, et al.
Publicado: (2020)

Sorafenib in Dupuytren and Ledderhose Disease
por: Schoenfeld, Joshua D, et al.
Publicado: (2022)

Metformin sensitizes sorafenib to inhibit postoperative recurrence and metastasis of hepatocellular carcinoma in orthotopic mouse models
por: You, Abin, et al.
Publicado: (2016)

Co-delivery of sorafenib and metformin from amphiphilic polypeptide-based micelles for colon cancer treatment
por: Zhang, Xiaohui, et al.
Publicado: (2022)

Sorafenib with interleukin-2 vs sorafenib alone in metastatic renal cell carcinoma: the ROSORC trial
por: Procopio, G, et al.
Publicado: (2011)

Efficacy of Sorafenib Monotherapy versus Sorafenib-Based Loco-Regional Treatments in Advanced Hepatocellular Carcinoma
por: Lee, Sangheun, et al.
Publicado: (2013)

Camrelizumab Plus Sorafenib Versus Sorafenib Monotherapy for Advanced Hepatocellular Carcinoma: A Retrospective Analysis
por: Liu, Qinqin, et al.
Publicado: (2021)

Ramucirumab combination with sorafenib enhances the inhibitory effect of sorafenib on HepG2 cancer cells
por: Taha, Amna Mohamed, et al.
Publicado: (2022)

Influence of Obesity and Type 2 Diabetes Mellitus on the Pharmacokinetics of Tramadol After Single Oral Dose Administration
por: Porażka, Joanna, et al.
Publicado: (2019)

Rapamycin weekly maintenance dosing and the potential efficacy of combination sorafenib plus rapamycin but not atorvastatin or doxycycline in tuberous sclerosis preclinical models
por: Lee, Nancy, et al.
Publicado: (2009)

Cannot write session to /tmp/vufind_sessions/sess_hc35c1nh2dis62p5dj3gbqlvrg