Improving Nefiracetam Dissolution and Solubility Behavior Using a Cocrystallization Approach

In this work, we are the first to identify thirteen cocrystals of Nefiracetam, a poor water-soluble nootropic compound. Three of which were obtained with the biocompatible cocrystallization agents citric acid, oxalic acid, and zinc chloride. These latter have been fully structurally and physically c...

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Autores principales: Buol, Xavier, Robeyns, Koen, Caro Garrido, Camila, Tumanov, Nikolay, Collard, Laurent, Wouters, Johan, Leyssens, Tom
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7408141/
https://www.ncbi.nlm.nih.gov/pubmed/32660115
http://dx.doi.org/10.3390/pharmaceutics12070653
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author Buol, Xavier
Robeyns, Koen
Caro Garrido, Camila
Tumanov, Nikolay
Collard, Laurent
Wouters, Johan
Leyssens, Tom
author_facet Buol, Xavier
Robeyns, Koen
Caro Garrido, Camila
Tumanov, Nikolay
Collard, Laurent
Wouters, Johan
Leyssens, Tom
author_sort Buol, Xavier
collection PubMed
description In this work, we are the first to identify thirteen cocrystals of Nefiracetam, a poor water-soluble nootropic compound. Three of which were obtained with the biocompatible cocrystallization agents citric acid, oxalic acid, and zinc chloride. These latter have been fully structurally and physically characterized and the solubility, dissolution rate, and stability were compared to that of the initial Active Pharmaceutical Ingredient (API).
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spelling pubmed-74081412020-08-25 Improving Nefiracetam Dissolution and Solubility Behavior Using a Cocrystallization Approach Buol, Xavier Robeyns, Koen Caro Garrido, Camila Tumanov, Nikolay Collard, Laurent Wouters, Johan Leyssens, Tom Pharmaceutics Article In this work, we are the first to identify thirteen cocrystals of Nefiracetam, a poor water-soluble nootropic compound. Three of which were obtained with the biocompatible cocrystallization agents citric acid, oxalic acid, and zinc chloride. These latter have been fully structurally and physically characterized and the solubility, dissolution rate, and stability were compared to that of the initial Active Pharmaceutical Ingredient (API). MDPI 2020-07-09 /pmc/articles/PMC7408141/ /pubmed/32660115 http://dx.doi.org/10.3390/pharmaceutics12070653 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Buol, Xavier
Robeyns, Koen
Caro Garrido, Camila
Tumanov, Nikolay
Collard, Laurent
Wouters, Johan
Leyssens, Tom
Improving Nefiracetam Dissolution and Solubility Behavior Using a Cocrystallization Approach
title Improving Nefiracetam Dissolution and Solubility Behavior Using a Cocrystallization Approach
title_full Improving Nefiracetam Dissolution and Solubility Behavior Using a Cocrystallization Approach
title_fullStr Improving Nefiracetam Dissolution and Solubility Behavior Using a Cocrystallization Approach
title_full_unstemmed Improving Nefiracetam Dissolution and Solubility Behavior Using a Cocrystallization Approach
title_short Improving Nefiracetam Dissolution and Solubility Behavior Using a Cocrystallization Approach
title_sort improving nefiracetam dissolution and solubility behavior using a cocrystallization approach
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7408141/
https://www.ncbi.nlm.nih.gov/pubmed/32660115
http://dx.doi.org/10.3390/pharmaceutics12070653
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