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Substrate Binding Stiffens Aspartate Aminotransferase by Altering the Enzyme Picosecond Vibrational Dynamics

[Image: see text] Protein dynamics on various time scales from femtoseconds to milliseconds impacts biological function by driving proteins to conformations conducive to ligand binding and creating functional states in enzyme catalysis. Neutron vibrational spectroscopy carried out by measuring inela...

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Detalles Bibliográficos
Autores principales:	Dajnowicz, Steven, Cheng, Yongqiang, Daemen, Luke L., Weiss, Kevin L., Gerlits, Oksana, Mueser, Timothy C., Kovalevsky, Andrey
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2020
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7408236/ https://www.ncbi.nlm.nih.gov/pubmed/32775880 http://dx.doi.org/10.1021/acsomega.0c01900

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