Design, Optimization, and Correlation of In Vitro/In Vivo Disintegration of Novel Fast Orally Disintegrating Tablet of High Dose Metformin Hydrochloride Using Moisture Activated Dry Granulation Process and Quality by Design Approach

Compression of cohesive, poorly compactable, and high-dose metformin hydrochloride into the orally disintegrating tablet (ODT) is challenging. The objective of this study was to develop metformin ODT using the moisture activated dry granulation (MADG) process. There are no reports in the literature...

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Detalles Bibliográficos
Autores principales: H. Aodah, Alhussain, H. Fayed, Mohamed, Alalaiwe, Ahmed, B. Alsulays, Bader, F. Aldawsari, Mohammed, Khafagy, El-Sayed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7408287/
https://www.ncbi.nlm.nih.gov/pubmed/32605039
http://dx.doi.org/10.3390/pharmaceutics12070598

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